Search Results - "Froning, Karen J."

Computationally Designed Bispecific Antibodies using Negative State Repertoires by Leaver-Fay, Andrew, Froning, Karen J., Atwell, Shane, Aldaz, Hector, Pustilnik, Anna, Lu, Frances, Huang, Flora, Yuan, Richard, Hassanali, Saleema, Chamberlain, Aaron K., Fitchett, Jonathan R., Demarest, Stephen J., Kuhlman, Brian

“…A challenge in the structure-based design of specificity is modeling the negative states, i.e., the complexes that you do not want to form. This is a difficult…”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by McCue, Amelia C, Demarest, Stephen J, Froning, Karen J, Hickey, Michael J, Antonysamy, Stephen, Kuhlman, Brian

“…T-cell engaging (TCE) bispecific antibodies are potent drugs that trigger the immune system to eliminate cancer cells, but administration can be accompanied by…”
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Generalizable design parameters for soluble T cell receptor-based T cell engagers by Froning, Karen J, Sereno, Arlene, Huang, Flora, Demarest, Stephen J

“…While most biological and cellular immunotherapies recognize extracellular targets, T cell receptor (TCR) therapeutics are unique in their ability to recognize…”
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A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase by Atwell, Shane, Adams, Jason M., Badger, John, Buchanan, Michelle D., Feil, Ingeborg K., Froning, Karen J., Gao, Xia, Hendle, Jörg, Keegan, Kevin, Leon, Barbara C., Müller-Dieckmann, Hans J., Nienaber, Vicki L., Noland, Brian W., Post, Kai, Rajashankar, K.R., Ramos, Aurora, Russell, Marijane, Burley, Stephen K., Buchanan, Sean G.

“…Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase required for signaling from immunoreceptors in various hematopoietic cells. Phosphorylation of…”
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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo by Buchanan, Sean G, Hendle, Jorg, Lee, Patrick S, Smith, Christopher R, Bounaud, Pierre-Yves, Jessen, Katti A, Tang, Crystal M, Huser, Nanni H, Felce, Jeremy D, Froning, Karen J, Peterman, Marshall C, Aubol, Brandon E, Gessert, Steve F, Sauder, J Michael, Schwinn, Kenneth D, Russell, Marijane, Rooney, Isabelle A, Adams, Jason, Leon, Barbara C, Do, Tuan H, Blaney, Jeff M, Sprengeler, Paul A, Thompson, Devon A, Smyth, Lydia, Pelletier, Laura A, Atwell, Shane, Holme, Kevin, Wasserman, Stephen R, Emtage, Spencer, Burley, Stephen K, Reich, Siegfried H

“…The MET receptor tyrosine kinase has emerged as an important target for the development of novel cancer therapeutics. Activation of MET by mutation or gene…”
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In vivo selection of single-chain antibodies using a yeast two-hybrid system by Pörtner-Taliana, Antje, Russell, Marijane, Froning, Karen J, Budworth, Paul R, Comiskey, John D, Hoeffler, James P

“…The current methodology for screening libraries of single-chain fragments of immunoglobulin variable domains (sFvs) utilizes bacterial phage systems. We have…”
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Computationally Designed Bispecific Antibodies using Negative State Repertoires by Leaver-Fay, Andrew, Froning, Karen J., Atwell, Shane, Aldaz, Hector, Pustilnik, Anna, Lu, Frances, Huang, Flora, Yuan, Richard, Hassanali, Saleema, Chamberlain, Aaron K., Fitchett, Jonathan R., Demarest, Stephen J., Kuhlman, Brian

“…A challenge in the structure-based design of specificity is modeling the negative states, i.e., the complexes that you do not want to form. Here, this is a…”
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CD8(positive) T cells in psoriatic lesions preferentially use T-cell receptor V(beta)3 and/or V(beta)13.1 genes by Chang, Jennie C C, Smith, Lawrence R, Froning, Karen J, Schwabe, Beverly J

“…The persistance of Vbeta3- and/or Vbeta13.1-bearing CD8positive T cells in psoriatic lesions that did not undergo resolution suggests that they are effector…”
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CD8+T Cells in Psoriatic Lesions Preferentially Use T-Cell Receptor Vβ3 and/or Vβ13.1 Genes by Jennie C. C. Chang, Smith, Lawrence R., Froning, Karen J., Schwabe, Beverly J., Laxer, Julie A., Caralli, Lisa L., Kurland, Helen H., Karasek, Marvin A., Wilkinson, David I., Carlo, Dennis J., Brestoff, Steven W.

“…Psoriasis is an inflammatory skin disorder characterized by epidermal keratinocyte hyperproliferation in association with a cellular infiltrate. There is…”
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Insulin-Secretory-Granule Specific T Cell Clones in Human IDDM by Chang, Jennie C.C., Linarelli, Louie G., Laxer, Julie A., Froning, Karen J., Caralli, Lisa L., Brostoff, Steven W., Carlo, Dennis J.

“…T cell clones reactive to β-cell antigens prepared from different species were established in order to identify putative pathogenic T cells in human IDDM. We…”
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Persistence of T-cell clones in psoriatic lesions by Chang, J C, Smith, L R, Froning, K J, Kurland, H H, Schwabe, B J, Blumeyer, K K, Karasek, M A, Wilkinson, D I, Farber, E M, Carlo, D J, Brostoff, S W

“…We previously demonstrated a clonal dominance in the V beta 13.1 messages isolated from the lesional CD8+ T cells of psoriasis vulgaris, which suggested an…”
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