Search Results - "Fromm Longo, Jody"

LPAR1 and aberrantly expressed LPAR3 differentially promote the migration and proliferation of malignant peripheral nerve sheath tumor cells by Doutt, Shannon Weber, Longo, Jody Fromm, Carroll, Steven L.

“…Schwann cell‐derived neoplasms known as malignant peripheral nerve sheath tumors (MPNSTs) are the most common malignancy and the leading cause of death in…”
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models by Jenkins, Dorea P, Turner-Ivey, Brittany, Fromm Longo, Jody, Carroll, Steven L

“…Patients with the autosomal dominant tumor susceptibility syndrome neurofibromatosis type 1 (NF1) commonly develop plexiform neurofibromas (PNs) that…”
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Establishment and genomic characterization of a sporadic malignant peripheral nerve sheath tumor cell line by Longo, Jody Fromm, Brosius, Stephanie N., Znoyko, Iya, Alers, Victoria A., Jenkins, Dorea P., Wilson, Robert C., Carroll, Andrew J., Wolff, Daynna J., Roth, Kevin A., Carroll, Steven L.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive Schwann cell-derived neoplasms that occur sporadically or in patients with neurofibromatosis…”
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells by Weber, Shannon M, Brossier, Nicole M, Prechtl, Amanda, Barnes, Stephen, Wilson, Landon S, Brosius, Stephanie N, Longo, Jody Fromm, Carroll, Steven L

“…Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1)…”
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ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms by Longo, Jody Fromm, Brosius, Stephanie N, Black, Laurel, Worley, Stuart H, Wilson, Robert C, Roth, Kevin A, Carroll, Steven L

“…We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However,…”
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Salinomycin targets the genome of radioresistant cells in glioblastomas by Carroll, Steven L, Longo, Jody Fromm

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The RASopathies: Biology, genetics and therapeutic options by Longo, Jody Fromm, Carroll, Steven L

“…The RASopathies are a group of genetic diseases in which the Ras/MAPK signaling pathway is inappropriately activated as a result of mutations in genes encoding…”
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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor by Turner-Ivey, Brittany, Longo, Jody Fromm, Jenkins, Dorea P, Guest, Stephen T, Carroll, Steven L

“…Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are derived from Schwann cells or their precursors. In patients with the tumor susceptibility syndrome…”
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Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms by Longo, Jody F, Weber, Shannon M, Turner-Ivey, Brittany P, Carroll, Steven L

“…The diagnosis of a neurofibroma or a malignant peripheral nerve sheath tumor (MPNST) often raises the question of whether the patient has the genetic disorder…”
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Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades by Brosius, Stephanie N, Turk, Amy N, Byer, Stephanie J, Longo, Jody Fromm, Kappes, John C, Roth, Kevin A, Carroll, Steven L

“…ABSTRACTChemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen…”
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Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells by Brossier, Nicole M., Prechtl, Amanda M., Longo, Jody Fromm, Barnes, Stephen, Wilson, Landon S., Byer, Stephanie J., Brosius, Stephanie N., Carroll, Steven L.

“…Neurofibromin, the tumor suppressor encoded by the neurofibromatosis type 1 (NF1) gene, potentially suppresses the activation of H-Ras, N-Ras, and K-Ras…”
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