Search Results - "Fromm, Simon A"

The translating bacterial ribosome at 1.55 Å resolution generated by cryo-EM imaging services by Fromm, Simon A., O’Connor, Kate M., Purdy, Michael, Bhatt, Pramod R., Loughran, Gary, Atkins, John F., Jomaa, Ahmad, Mattei, Simone

“…Our understanding of protein synthesis has been conceptualised around the structure and function of the bacterial ribosome. This complex macromolecular machine…”
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Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex by Lawrence, Rosalie E, Fromm, Simon A, Fu, Yangxue, Yokom, Adam L, Kim, Do Jin, Thelen, Ashley M, Young, Lindsey N, Lim, Chun-Yan, Samelson, Avi J, Hurley, James H, Zoncu, Roberto

“…The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its…”
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Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds by Mann, Daniel, Fromm, Simon A., Martinez-Sanchez, Antonio, Gopaldass, Navin, Choy, Ramona, Mayer, Andreas, Sachse, Carsten

“…Autophagy-related protein 18 (Atg18) participates in the elongation of early autophagosomal structures in concert with Atg2 and Atg9 complexes. How Atg18…”
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Structural basis for the ARF GAP activity and specificity of the C9orf72 complex by Su, Ming-Yuan, Fromm, Simon A., Remis, Jonathan, Toso, Daniel B., Hurley, James H.

“…Mutation of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontal temporal degeneration (FTD), which is attributed to…”
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Seeing tobacco mosaic virus through direct electron detectors by Fromm, Simon A., Bharat, Tanmay A.M., Jakobi, Arjen J., Hagen, Wim J.H., Sachse, Carsten

“…With the introduction of direct electron detectors (DED) to the field of electron cryo-microscopy, a wave of atomic-resolution structures has become available…”
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The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex by Fromm, Simon A, Truffault, Vincent, Kamenz, Julia, Braun, Joerg E, Hoffmann, Niklas A, Izaurralde, Elisa, Sprangers, Remco

“…The Dcp1:Dcp2 decapping complex catalyses the removal of the mRNA 5′ cap structure. Activator proteins, including Edc3 (enhancer of decapping 3), modulate its…”
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Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation by Jansen, Rachel M, Peruzzo, Roberta, Fromm, Simon A, Yokom, Adam L, Zoncu, Roberto, Hurley, James H

“…The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and catabolism in response to nutrients through phosphorylation of key substrates…”
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Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD by Su, Ming-Yuan, Fromm, Simon A., Zoncu, Roberto, Hurley, James H.

“…Mutation of C9orf72 is the most prevalent defect associated with amyotrophic lateral sclerosis and frontotemporal degeneration 1 . Together with…”
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Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9 by Fromm, Simon A., Lawrence, Rosalie E., Hurley, James H.

“…The Rag GTPases (Rags) recruit mTORC1 to the lysosomal membrane in response to nutrients, where it is then activated in response to energy and growth factor…”
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InVitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery by Fromm, Simon A, Kamenz, Julia, Noldeke, Erik R, Neu, Ancilla, Zocher, Georg, Sprangers, Remco

“…In eukaryotic cells, components of the 5' to 3' mRNA degradation machinery can undergo a rapid phase transition. The resulting cytoplasmic foci are referred to…”
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In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery by Fromm, Simon A., Kamenz, Julia, Nöldeke, Erik R., Neu, Ancilla, Zocher, Georg, Sprangers, Remco

“…In eukaryotic cells, components of the 5′ to 3′ mRNA degradation machinery can undergo a rapid phase transition. The resulting cytoplasmic foci are referred to…”
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Structure of the C9orf72 Arf GAP complex haploinsufficient in ALS and FTD by Su, Ming-Yuan, Fromm, Simon A., Zoncu, Roberto, Hurley, James H.

“…Mutation of C9ORF72 is the most prevalent defect in amyotrophic lateral sclerosis (ALS) and frontal temporal degeneration (FTD) 1 . Together with…”
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Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination by Henderikx, Rene J.M., Schotman, Maaike J.G., Shahzad, Saba, Fromm, Simon A., Mann, Daniel, Hennies, Julian, Heidler, Thomas V., Ashtiani, Dariush, Hagen, Wim J.H., Jeurissen, Roger J.M., Mattei, Simone, Peters, Peter J., Sachse, Carsten, Beulen, Bart W.A.M.M.

“…•Methods in the VitroJet allow for on-the-fly ice thickness tuning and measurement.•The optical camera can estimate ice thickness ranging from 0 to…”
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Mechanism of RNA polymerase I selection by transcription factor UAF by Baudin, Florence, Murciano, Brice, Fung, Herman K H, Fromm, Simon A, Mattei, Simone, Mahamid, Julia, Müller, Christoph W

“…Preribosomal RNA is selectively transcribed by RNA polymerase (Pol) I in eukaryotes. The yeast transcription factor upstream activating factor (UAF) represses…”
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The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding by Audin, Maxime J. C., Dorn, Georg, Fromm, Simon A., Reiss, Kerstin, Schütz, Stefan, Vorländer, Matthias K., Sprangers, Remco

“…Big and unexpectedly flexible: The 173 kDa exosome core is unexpectedly dynamic in solution. The kinetic and thermodynamic properties connected with the…”
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Journal of Structural Biology – Paper of the Year 2018

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The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding by Audin, Maxime J. C., Dorn, Georg, Fromm, Simon A., Reiss, Kerstin, Schütz, Stefan, Vorländer, Matthias K., Sprangers, Remco

“…Groß und unerwartet flexibel: Der 173‐kDa‐Exosomkernkomplex erweist sich in Lösung als unerwartet dynamisch. Die kinetischen und thermodynamischen Daten des…”
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In-vitro-Rekonstitution eines zellulären Phasenübergangs unter Beteiligung der mRNA-Decapping-Maschinerie by Fromm, Simon A., Kamenz, Julia, Nöldeke, Erik R., Neu, Ancilla, Zocher, Georg, Sprangers, Remco

“…In eukaryotischen Zellen können die Komponenten des 5′‐3′‐Abbaumechanismus der Boten‐RNA (mRNA) einen schnellen Phasenübergang durchlaufen. Die resultierenden…”
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The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex: Structure of the Edc3-Dcp2 complex by Fromm, Simon A, Truffault, Vincent, Kamenz, Julia, Braun, Joerg E, Hoffmann, Niklas A, Izaurralde, Elisa, Sprangers, Remco

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In‐vitro‐Rekonstitution eines zellulären Phasenübergangs unter Beteiligung der mRNA‐Decapping‐Maschinerie by Fromm, Simon A., Kamenz, Julia, Nöldeke, Erik R., Neu, Ancilla, Zocher, Georg, Sprangers, Remco

“…In eukaryotischen Zellen können die Komponenten des 5′‐3′‐Abbaumechanismus der Boten‐RNA (mRNA) einen schnellen Phasenübergang durchlaufen. Die resultierenden…”
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