Search Results - "Fromm, F"

Clinical Aspects of Transporter‐Mediated Drug–Drug Interactions by Gessner, Arne, König, Jörg, Fromm, Martin F.

“…Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma concentrations of the victim drug can be modified by drug–drug…”
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Transporters and drug-drug interactions: important determinants of drug disposition and effects by König, Jörg, Müller, Fabian, Fromm, Martin F

“…Uptake and efflux transporters determine plasma and tissue concentrations of a broad variety of drugs. They are localized in organs such as small intestine,…”
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Importance of P-glycoprotein at blood–tissue barriers by Fromm, Martin F.

“…P-glycoprotein is the product of the ABCB1 [also known as multidrug resistance 1 ( MDR1)] gene. It translocates a broad variety of xenobiotics out of cells…”
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Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease by Schumann, Tina, König, Jörg, Henke, Christine, Willmes, Diana M, Bornstein, Stefan R, Jordan, Jens, Fromm, Martin F, Birkenfeld, Andreas L

“…The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating the influx and efflux of substances such as ions, nucleotides, and…”
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The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine by Taghikhani, Emir, Maas, Renke, Fromm, Martin F, König, Jörg

“…Elevated plasma concentrations of the uremic toxin asymmetrical dimethylarginine (ADMA) and low plasma concentrations of L-homoarginine are independently…”
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Beyond bulk: Density fractions explain heterogeneity in global soil carbon abundance and persistence by Heckman, Katherine, Hicks Pries, Caitlin E., Lawrence, Corey R., Rasmussen, Craig, Crow, Susan E., Hoyt, Alison M., Fromm, Sophie F., Shi, Zheng, Stoner, Shane, McGrath, Casey, Beem‐Miller, Jeffrey, Berhe, Asmeret Asefaw, Blankinship, Joseph C., Keiluweit, Marco, Marín‐Spiotta, Erika, Monroe, J. Grey, Plante, Alain F., Schimel, Joshua, Sierra, Carlos A., Thompson, Aaron, Wagai, Rota

“…Understanding the controls on the amount and persistence of soil organic carbon (C) is essential for predicting its sensitivity to global change. The response…”
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ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin by Keskitalo, JE, Zolk, O, Fromm, MF, Kurkinen, KJ, Neuvonen, PJ, Niemi, M

“…The ABCG2 c.421C>A single‐nucleotide polymorphism (SNP) was determined in 660 healthy Finnish volunteers, of whom 32 participated in a pharmacokinetic…”
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Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein by Knop, Jana, Misaka, Shingen, Singer, Katrin, Hoier, Eva, Müller, Fabian, Glaeser, Hartmut, König, Jörg, Fromm, Martin F

“…Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate the uptake of a diverse group of drugs and endogenous…”
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Transporter-Mediated Drug Uptake and Efflux: Important Determinants of Adverse Drug Reactions by Zolk, O, Fromm, MF

“…Transporter proteins mediate the cellular uptake and efflux of a broad variety of endogenous compounds, drugs, and their metabolites. Their systemic plasma…”
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Transporter-mediated drug-drug interactions by Müller, Fabian, Fromm, Martin F

“…Drug-drug interactions are a serious clinical issue. An important mechanism underlying drug-drug interactions is induction or inhibition of drug transporters…”
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Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates by Hacker, Kristina, Maas, Renke, Kornhuber, Johannes, Fromm, Martin F, Zolk, Oliver

“…The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which…”
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The quasi-free-standing nature of graphene on H-saturated SiC(0001) by Speck, F., Jobst, J., Fromm, F., Ostler, M., Waldmann, D., Hundhausen, M., Weber, H. B., Seyller, Th

“…We report on an investigation of quasi-free-standing graphene on 6H-SiC(0001) which was prepared by intercalation of hydrogen under the buffer layer. Using…”
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New Oral Anti-Cancer Drugs and Medication Safety by Schlichtig, Katja, Dürr, Pauline, Dörje, Frank, Fromm, Martin F

“…Many oral anti-cancer drugs have come onto the market in the past 20 years. For example, kinase inhibitors, such as the BCR-ABL and BRAF inhibitors, have…”
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Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models by Haberkorn, Bastian, Fromm, Martin F, König, Jörg

“…Organic Cation Transporter 1 (OCT1, gene symbol: ) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and…”
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A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter‐Mediated Drug‐Drug Interactions by Gessner, Arne, Müller, Fabian, Wenisch, Pia, Heinrich, Markus R., König, Jörg, Stopfer, Peter, Fromm, Martin F.

“…Endogenous biomarkers are discussed as tools for detection of drug‐drug interactions (DDIs) mediated by renal transport proteins, such as organic cation…”
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Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects by Misaka, S, Yatabe, J, Müller, F, Takano, K, Kawabe, K, Glaeser, H, Yatabe, M S, Onoue, S, Werba, J P, Watanabe, H, Yamada, S, Fromm, M F, Kimura, J

“…This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β‐blocker nadolol. Ten healthy volunteers received a…”
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Contribution of the buffer layer to the Raman spectrum of epitaxial graphene on SiC(0001) by Fromm, F, Oliveira Jr, M H, Molina-Sánchez, A, Hundhausen, M, Lopes, J M J, Riechert, H, Wirtz, L, Seyller, T

“…We report a Raman study of the so-called buffer layer with periodicity which forms the intrinsic interface structure between epitaxial graphene and SiC(0001)…”
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Double‐transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations by König, J, Zolk, O, Singer, K, Hoffmann, C, Fromm, MF

“…BACKGROUND AND PURPOSE The organic cation transporters 1 (OCT1) and 2 (OCT2) mediate drug uptake into hepatocytes and renal proximal tubular cells,…”
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Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine by Wiebe, Sabrina T., Giessmann, Thomas, Hohl, Kathrin, Schmidt-Gerets, Sven, Hauel, Edith, Jambrecina, Alen, Bader, Kerstin, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Mikus, Gerd, Fromm, Martin F., Müller, Fabian, Stopfer, Peter

“…Background and Objective A novel cocktail containing four substrates of key drug transporters was previously optimized to eliminate mutual drug–drug…”
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Controls and relationships of soil organic carbon abundance and persistence vary across pedo‐climatic regions by Fromm, Sophie F., Hoyt, Alison M., Sierra, Carlos A., Georgiou, Katerina, Doetterl, Sebastian, Trumbore, Susan E.

“…One of the largest uncertainties in the terrestrial carbon cycle is the timing and magnitude of soil organic carbon (SOC) response to climate and vegetation…”
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