Search Results - "Fromm, Bastian"
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A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
Published in Annual review of genetics (23-11-2015)“…Although microRNAs (miRNAs) are among the most intensively studied molecules of the past 20 years, determining what is and what is not a miRNA has not been…”
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Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes
Published in Molecular cancer (05-10-2017)“…The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this…”
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RNAcentral 2021: secondary structure integration, improved sequence search and new member databases
Published in Nucleic acids research (08-01-2021)“…Abstract RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides a single access point to 44 RNA resources and >18 million…”
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Atp8 is in the ground pattern of flatworm mitochondrial genomes
Published in BMC genomics (26-05-2017)“…To date, mitochondrial genomes of more than one hundred flatworms (Platyhelminthes) have been sequenced. They show a high degree of similarity and a strong…”
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Common diseases alter the physiological age-related blood microRNA profile
Published in Nature communications (24-11-2020)“…Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their…”
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Rapid adaptation of cellular metabolic rate to the MicroRNA complements of mammals and its relevance to the evolution of endothermy
Published in iScience (16-02-2024)“…The metabolic efficiency of mammalian cells depends on the attenuation of intrinsic translation noise by microRNAs. We devised a metric of cellular metabolic…”
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miRTrace reveals the organismal origins of microRNA sequencing data
Published in Genome Biology (04-12-2018)“…We present here miRTrace, the first algorithm to trace microRNA sequencing data back to their taxonomic origins. This is a challenge with profound implications…”
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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA
Published in Nature (London) (02-07-2020)“…MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At present, the major parameter that can explain the selection of the target…”
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MirGeneDB 2.1: toward a complete sampling of all major animal phyla
Published in Nucleic acids research (07-01-2022)“…Abstract We describe an update of MirGeneDB, the manually curated microRNA gene database. Adhering to uniform and consistent criteria for microRNA annotation…”
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The microRNA toolkit of insects
Published in Scientific reports (24-11-2016)“…Is there a correlation between miRNA diversity and levels of organismic complexity? Exhibiting extraordinary levels of morphological and developmental…”
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Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki
Published in eLife (07-08-2024)“…The evolutionary origins of Bilateria remain enigmatic. One of the more enduring proposals highlights similarities between a cnidarian-like planula larva and…”
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MapToCleave: High-throughput profiling of microRNA biogenesis in living cells
Published in Cell reports (Cambridge) (16-11-2021)“…Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted…”
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Unicellular Origin of the Animal MicroRNA Machinery
Published in Current biology (22-10-2018)“…The emergence of multicellular animals was associated with an increase in phenotypic complexity and with the acquisition of spatial cell differentiation and…”
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A comparative analysis of heart microRNAs in vertebrates brings novel insights into the evolution of genetic regulatory networks
Published in BMC genomics (04-03-2021)“…During vertebrate evolution, the heart has undergone remarkable changes that lead to morphophysiological differences in the fully formed heart of these…”
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Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
Published in Cell reports (Cambridge) (08-12-2020)“…We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated,…”
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Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk
Published in Journal of extracellular vesicles (01-12-2019)“…The prevalent porcine helminth, Ascaris suum, compromises pig health and reduces farm productivity worldwide. The closely related human parasite, A…”
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Large scale changes in the transcriptome of Eisenia fetida during regeneration
Published in PloS one (27-09-2018)“…Earthworms show a wide spectrum of regenerative potential with certain species like Eisenia fetida capable of regenerating more than two-thirds of their body…”
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A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case
Published in BMC evolutionary biology (03-03-2009)“…Neuropeptide ligands have to fit exactly into their respective receptors and thus the evolution of the coding regions of their genes is constrained and may be…”
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A renaissance of microRNAs as taxonomic and phylogenetic markers in animals
Published in Zoologica scripta (01-11-2024)“…Molecular markers for tracing animal sample origins and compositions are critical for applications such as parasite detection, contamination screening, and…”
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Evolutionary Implications of the microRNA- and piRNA Complement of Lepidodermella squamata (Gastrotricha)
Published in Non-coding RNA (22-02-2019)“…Gastrotrichs-'hairy bellies'-are microscopic free-living animals inhabiting marine and freshwater habitats. Based on morphological and early molecular…”
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