Search Results - "Frolova, Elena"

Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff by Akhrymuk, Ivan, Frolov, Ilya, Frolova, Elena I

“…Sindbis virus (SINV) is a representative member of the genus in the Togaviridae family. The hallmark of SINV replication in vertebrate cells is a rapid…”
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New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes by Kim, Dal Young, Reynaud, Josephine M, Rasalouskaya, Aliaksandra, Akhrymuk, Ivan, Mobley, James A, Frolov, Ilya, Frolova, Elena I

“…The positive-strand RNA viruses initiate their amplification in the cell from a single genome delivered by virion. This single RNA molecule needs to become…”
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Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication by Atasheva, Svetlana, Frolova, Elena I, Frolov, Ilya

“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling by Frolova, Elena I, Palchevska, Oksana, Lukash, Tetyana, Dominguez, Francisco, Britt, William, Frolov, Ilya

“…Circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human population leads to further viral evolution. The new variants that…”
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Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode by Akhrymuk, Ivan, Frolov, Ilya, Frolova, Elena I

“…Abstract Alphaviruses are a family of positive-strand RNA viruses that circulate on all continents between mosquito vectors and vertebrate hosts. Despite a…”
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Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence by Meshram, Chetan D, Shiliaev, Nikita, Frolova, Elena I, Frolov, Ilya

“…Eastern equine encephalitis virus (EEEV) is the most pathogenic member of the genus in the family. This virus continues to circulate in the New World and has a…”
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Evasion of the Innate Immune Response: the Old World Alphavirus nsP2 Protein Induces Rapid Degradation of Rpb1, a Catalytic Subunit of RNA Polymerase II by AKHRYMUK, Ivan, KULEMZIN, Sergey V, FROLOVA, Elena I

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Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication Rates by Akhrymuk, Ivan, Lukash, Tetyana, Frolov, Ilya, Frolova, Elena I

“…Alphavirus infections are characterized by global inhibition of cellular transcription and rapid induction of a cytopathic effect (CPE) in cells of vertebrate…”
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Alphavirus-induced transcriptional and translational shutoffs play major roles in blocking the formation of stress granules by Frolova, Elena I., Palchevska, Oksana, Dominguez, Francisco, Frolov, Ilya

“…ABSTRACT Alphavirus infections cause multiple alterations in the intracellular environment that can have both positive and negative effects on viral…”
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Alphavirus-based replicons demonstrate different interactions with host cells and can be optimized to increase protein expression by Dominguez, Francisco, Palchevska, Oksana, Frolova, Elena I., Frolov, Ilya

“…ABSTRACT Alphaviruses have been used as vectors for the expression of heterologous genetic information for a few decades. Their genomes contain two open…”
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1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution by Agback, Tatiana, Dominguez, Francisco, Frolov, Ilya, Frolova, Elena I, Agback, Peter

“…Structural characterization of the SARS-CoV-2 full length nsp1 protein will be an essential tool for developing new target-directed antiviral drugs against…”
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All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein by Frolov, Ilya, Agback, Tatiana, Palchevska, Oksana, Dominguez, Francisco, Lomzov, Alexander, Agback, Peter, Frolova, Elena I

“…Replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strongly affects cellular metabolism and results in rapid development of the…”
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New PARP Gene with an Anti-Alphavirus Function by ATASHEVA, Svetlana, AKHRYMUK, Maryna, FROLOVA, Elena I, FROLOV, Ilya

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IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon by Reynaud, Josephine M, Kim, Dal Young, Atasheva, Svetlana, Rasalouskaya, Aliaksandra, White, James P, Diamond, Michael S, Weaver, Scott C, Frolova, Elena I, Frolov, Ilya

“…Alphaviruses are a group of widely distributed human and animal pathogens. It is well established that their replication is sensitive to type I IFN treatment,…”
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Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode by Meshram, Chetan D, Agback, Peter, Shiliaev, Nikita, Urakova, Nadya, Mobley, James A, Agback, Tatiana, Frolova, Elena I, Frolov, Ilya

“…Alphaviruses are widely distributed in both hemispheres and circulate between mosquitoes and amplifying vertebrate hosts. Geographically separated alphaviruses…”
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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome by Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K, Sokratian, Arpine, Guthrie, David B, Kolykhalov, Alexander A, Lockwood, Mark A, Natchus, Michael G, Crowley, Michael R, Painter, George R, Frolova, Elena I, Frolov, Ilya

“…Venezuelan equine encephalitis virus (VEEV) is a representative member of the New World alphaviruses. It is transmitted by mosquito vectors and causes highly…”
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Functional Sindbis Virus Replicative Complexes Are Formed at the Plasma Membrane by FROLOVA, Elena I, GORCHAKOV, Rodion, PEREBOEVA, Larisa, ATASHEVA, Svetlana, FROLOV, Ilya

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Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein by Lukash, Tetyana, Agback, Tatiana, Dominguez, Francisco, Shiliaev, Nikita, Meshram, Chetan, Frolova, Elena I, Agback, Peter, Frolov, Ilya

“…Decades of insufficient control have resulted in unprecedented spread of chikungunya virus (CHIKV) around the globe, and millions have suffered from the highly…”
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Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly by Frolov, Ilya, Kim, Dal Young, Akhrymuk, Maryna, Mobley, James A, Frolova, Elena I

“…Eastern equine encephalitis virus (EEEV) is a representative member of the New World alphaviruses. It is pathogenic for a variety of vertebrate hosts, in which…”
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Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis by Pavasini, Rita, Guralnik, Jack, Brown, Justin C, di Bari, Mauro, Cesari, Matteo, Landi, Francesco, Vaes, Bert, Legrand, Delphine, Verghese, Joe, Wang, Cuiling, Stenholm, Sari, Ferrucci, Luigi, Lai, Jennifer C, Bartes, Anna Arnau, Espaulella, Joan, Ferrer, Montserrat, Lim, Jae-Young, Ensrud, Kristine E, Cawthon, Peggy, Turusheva, Anna, Frolova, Elena, Rolland, Yves, Lauwers, Valerie, Corsonello, Andrea, Kirk, Gregory D, Ferrari, Roberto, Volpato, Stefano, Campo, Gianluca

“…The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for…”
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