Search Results - "Froestl, Wolfgang"

Genetic and pharmacological evidence of a role for GABAB receptors in the modulation of anxiety- and antidepressant-like behavior by MOMBEREAU, Cedric, KAUPMANN, Klemens, FROESTL, Wolfgang, SANSIG, Gilles, VAN DER PUTTEN, Herman, CRYAN, John F

“…Although there is much evidence for a role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the pathophysiology of anxiety and depression,…”
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Chemistry and pharmacology of GABAB receptor ligands by Froestl, Wolfgang

“…This chapter presents new clinical applications of the prototypic GABA(B) receptor agonist baclofen for the treatment of addiction by drugs of abuse, such as…”
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Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats by PATERSON, Neil E, FROESTL, Wolfgang, MARKOU, Athina

“…Acute administration of gamma-aminobutyric acid B (GABAB) receptor agonists decreased nicotine, cocaine, ethanol, and heroin self-administration. GABAB…”
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Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines by Cryan, John F, Kelly, Peter H, Chaperon, Frederique, Gentsch, Conrad, Mombereau, Cedric, Lingenhoehl, Kurt, Froestl, Wolfgang, Bettler, Bernhard, Kaupmann, Klemens, Spooren, Will P J M

“…The role of GABAB receptors in various behavioral processes has been largely defined using the prototypical GABAB receptor agonist baclofen. However, baclofen…”
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SGS742: the first GABAB receptor antagonist in clinical trials by FROESTL, Wolfgang, GALLAGHER, Michela, JENKINS, Helen, MADRID, Annette, MELCHER, Thorsten, TEICHMAN, Sam, MONDADORI, Cesare G, PEARLMAN, Rodney

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The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat by Patel, Sadhana, Naeem, Sami, Kesingland, Adam, Froestl, Wolfgang, Capogna, Marco, Urban, Laszlo, Fox, Alyson

“…We have examined the effects of a novel GABAB agonist, CGP35024, in models of chronic neuropathic (partial sciatic ligation) and inflammatory (Freund's…”
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An historical perspective on GABAergic drugs by Froestl, Wolfgang

“…In 1950, γ-aminobutyric acid (GABA) was discovered in the brain and in 1967 it was recognized as an inhibitory neurotransmitter. The discovery of the…”
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Human γ -aminobutyric Acid Type B Receptors are Differentially Expressed and Regulate Inwardly Rectifying K+Channels by Kaupmann, Klemens, Schuler, Valerie, Mosbacher, Johannes, Bischoff, Serge, Bittiger, Helmut, Heid, Jakob, Froestl, Wolfgang, Leonhard, Sabine, Pfaff, Torsten, Karschin, Andreas, Bettler, Bernhard

“…γ -Aminobutyric acid type B receptors (GABABRs) are involved in the fine tuning of inhibitory synaptic transmission. Presynaptic GABABRs inhibit…”
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Activation of the GABAB Receptor Prevents Nicotine-Induced Locomotor Stimulation in Mice by Lobina, Carla, Carai, Mauro A. M., Froestl, Wolfgang, Mugnaini, Claudia, Pasquini, Serena, Corelli, Federico, Gessa, Gian Luigi, Colombo, Giancarlo

“…Recent studies demonstrated that activation of the GABA B receptor, either by means of orthosteric agonists or positive allosteric modulators (PAMs), inhibited…”
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Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria) by Gupta, Maneesh, Greven, Rachel, Jansen, Erwin E W, Jakobs, Cornelis, Hogema, Boris M, Froestl, Wolfgang, Snead, O Carter, Bartels, Hilke, Grompe, Markus, Gibson, K Michael

“…Therapeutic intervention for human succinic semialdehyde dehydrogenase (SSADH) deficiency (gamma-hydroxybutyric aciduria) has been limited to vigabatrin (VGB)…”
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Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats by MACCIONI, Paola, PES, Daniela, ORRU, Alessandro, FROESTL, Wolfgang, LUIGI GESSA, Gian, CARAI, Mauro A. M, COLOMBO, Giancarlo

“…Rationale and objectives: The positive allosteric modulator of the GABAB receptor, GS39783, has recently been found to suppress acquisition and maintenance of…”
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The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine : Intracranial self-stimulation studies in the rat by SLATTERY, David A, MARKOU, Athina, FROESTL, Wolfgang, CRYAN, John F

“…There is an increasing interest in the development of nondopaminergic pharmacotherapies for cocaine abuse. Emerging preclinical and clinical data with the…”
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Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists by Froestl, Wolfgang, Mickel, Stuart J, Hall, Roger G, von Sprecher, Georg, Strub, Dietrich, Baumann, Peter A, Brugger, Felix, Gentsch, Conrad, Jaekel, Joachim

“…The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABAB receptors. For many years efforts to…”
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Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists by Froestl, Wolfgang, Mickel, Stuart J, von Sprecher, Georg, Diel, Peter J, Hall, Roger G, Maier, Ludwig, Strub, Dietrich, Melillo, Vito, Baumann, Peter A

“…In 1987, 25 years after the synthesis of the potent and selective GABAB agonist baclofen (1), Kerr et al. described the first GABAB antagonist phaclofen 2…”
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Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors by Froestl, Wolfgang, Muhs, Andreas, Pfeifer, Andrea

“…Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit…”
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Novel GABA(B) receptor positive modulators: a patent survey by Froestl, Wolfgang

“…Positive allosteric modulators of GABA(B) receptors may have a similar potential as positive modulators of GABA(A) receptors, the benzodiazepines discovered in…”
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In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor by CARAI, Mauro A. M, COLOMBO, Giancarlo, FROESTL, Wolfgang, GESSA, Gian Luigi

“…The present study was aimed at assessing the in vivo effectiveness of the positive allosteric modulator of the gamma-aminobutyric acidB (GABAB) receptor,…”
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Cognitive enhancers (Nootropics). Part 1: drugs interacting with receptors. Update 2014 by Froestl, Wolfgang, Muhs, Andreas, Pfeifer, Andrea

“…Scientists working in the fields of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review "Cognitive enhancers…”
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CGP 35348: a centrally active blocker of GABAB receptors by Olpe, H R, Karlsson, G, Pozza, M F, Brugger, F, Steinmann, M, Van Riezen, H, Fagg, G, Hall, R G, Froestl, W, Bittiger, H

“…The biochemical, electrophysiological and pharmacological properties of the new GABAB receptor blocker CGP 35348 are described. In a variety of receptor…”
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Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes. Update 2014 by Froestl, Wolfgang, Muhs, Andreas, Pfeifer, Andrea

“…Scientists working in the field of Alzheimer's disease and, in particular, cognitive enhancers are very productive. The review on Drugs interacting with…”
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