Search Results - "Froeling, Fieke"

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression by Froeling, Fieke E.M, Feig, Christine, Chelala, Claude, Dobson, Richard, Mein, Charles E, Tuveson, David A, Clevers, Hans, Hart, Ian R, Kocher, Hemant M

“…Background & Aims Patients with pancreatic ductal adenocarcinoma are deficient in vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We…”
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Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer by Kocher, Hemant M., Basu, Bristi, Froeling, Fieke E. M., Sarker, Debashis, Slater, Sarah, Carlin, Dominic, deSouza, Nandita M., De Paepe, Katja N., Goulart, Michelle R., Hughes, Christine, Imrali, Ahmet, Roberts, Rhiannon, Pawula, Maria, Houghton, Richard, Lawrence, Cheryl, Yogeswaran, Yathushan, Mousa, Kelly, Coetzee, Carike, Sasieni, Peter, Prendergast, Aaron, Propper, David J.

“…Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic…”
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Homologous Recombination Deficiency in Pancreatic Cancer: A Systematic Review and Prevalence Meta-Analysis by Casolino, Raffaella, Paiella, Salvatore, Azzolina, Danila, Beer, Philip A, Corbo, Vincenzo, Lorenzoni, Giulia, Gregori, Dario, Golan, Talia, Braconi, Chiara, Froeling, Fieke E M, Milella, Michele, Scarpa, Aldo, Pea, Antonio, Malleo, Giuseppe, Salvia, Roberto, Bassi, Claudio, Chang, David K, Biankin, Andrew V

“…To analyze the prevalence of homologous recombination deficiency (HRD) in patients with pancreatic ductal adenocarcinoma (PDAC). We conducted a systematic…”
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Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours by Froeling, Fieke E. M., Ramaswami, Ramya, Papanastasopoulos, Panagiotis, Kaur, Baljeet, Sebire, Neil J., Short, Dee, Fisher, Rosemary A., Sarwar, Naveed, Wells, Michael, Singh, Kam, Ellis, Laura, Horsman, Janet M., Winter, Matthew C., Tidy, John, Hancock, Barry W., Seckl, Michael J.

“…Background Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease…”
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Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution by Chan-Seng-Yue, Michelle, Kim, Jaeseung C., Wilson, Gavin W., Ng, Karen, Figueroa, Eugenia Flores, O’Kane, Grainne M., Connor, Ashton A., Denroche, Robert E., Grant, Robert C., McLeod, Jessica, Wilson, Julie M., Jang, Gun Ho, Zhang, Amy, Dodd, Anna, Liang, Sheng-Ben, Borgida, Ayelet, Chadwick, Dianne, Kalimuthu, Sangeetha, Lungu, Ilinca, Bartlett, John M. S., Krzyzanowski, Paul M., Sandhu, Vandana, Tiriac, Hervé, Froeling, Fieke E. M., Karasinska, Joanna M., Topham, James T., Renouf, Daniel J., Schaeffer, David F., Jones, Steven J. M., Marra, Marco A., Laskin, Janessa, Chetty, Runjan, Stein, Lincoln D., Zogopoulos, George, Haibe-Kains, Benjamin, Campbell, Peter J., Tuveson, David A., Knox, Jennifer J., Fischer, Sandra E., Gallinger, Steven, Notta, Faiyaz

“…Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients. The basis of this disease heterogeneity has proved difficult to…”
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Molecular Subtyping and Precision Medicine for Pancreatic Cancer by Froeling, Fieke E M, Casolino, Raffaella, Pea, Antonio, Biankin, Andrew V, Chang, David K

“…Substantial progress in recent years has dramatically increased our knowledge of the molecular basis of cancer, revealing new potential therapeutic targets and…”
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Organotypic Culture Model of Pancreatic Cancer Demonstrates that Stromal Cells Modulate E-Cadherin, β-Catenin, and Ezrin Expression in Tumor Cells by Froeling, Fieke E.M, Mirza, Tariq A, Feakins, Roger M, Seedhar, Angela, Elia, George, Hart, Ian R, Kocher, Hemant M

“…Pancreatic cancer is characterized by an intense stromal reaction. Reproducible three-dimensional in vitro systems for exploring interactions of the stroma…”
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Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death by Froeling, Fieke E M, Swamynathan, Manojit Mosur, Deschênes, Astrid, Chio, Iok In Christine, Brosnan, Erin, Yao, Melissa A, Alagesan, Priya, Lucito, Matthew, Li, Juying, Chang, An-Yun, Trotman, Lloyd C, Belleau, Pascal, Park, Youngkyu, Rogoff, Harry A, Watson, James D, Tuveson, David A

“…Napabucasin (2-acetylfuro-1,4-naphthoquinone or BBI-608) is a small molecule currently being clinically evaluated in various cancer types. It has mostly been…”
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Internally Controlled and Dynamic Optical Measures of Functional Tumor Biology by Chung, Taemoon, Garcia, Libia, Swamynathan, Manojit M., Froeling, Fieke E. M., Trotman, Lloyd C., Tuveson, David A., Lyons, Scott K.

“…Imaging defined aspects of functional tumor biology with bioluminescent reporter transgenes is a popular approach in preclinical drug development as it is…”
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Exploring the Biology of Cancer-Associated Fibroblasts in Pancreatic Cancer by Bryce, Adam S, Dreyer, Stephan B, Froeling, Fieke E. M, Chang, David K

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy characterised by a stubbornly low 5-year survival which is essentially unchanged in the past 5…”
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Pancreatic cancer organotypic cultures by Froeling, Fieke E.M., Marshall, John F., Kocher, Hemant M.

“…Pancreatic cancer, the fourth most common cause of cancer-related death, is a devastating disease with poor prognosis. Over the last four decades, no effective…”
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Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes by Kadaba, Raghu, Birke, Hanna, Wang, Jun, Hooper, Steven, Andl, Claudia D, Di Maggio, Francesco, Soylu, Erdinc, Ghallab, Mohammed, Bor, Daniel, Froeling, Fieke EM, Bhattacharya, Satyajit, Rustgi, Anil K, Sahai, Erik, Chelala, Claude, Sasieni, Peter, Kocher, Hemant M

“…Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal cells is well recognized…”
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Homeostatic Restoration of Desmoplastic Stroma Rather Than Its Ablation Slows Pancreatic Cancer Progression by Froeling, Fieke E.M, Kocher, Hemant M

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Gestational Trophoblastic Tumours: An Update for 2014 by Froeling, Fieke E. M., Seckl, Michael J.

“…Gestational trophoblastic disease describes a variety of pregnancy-related diseases including the premalignant conditions of a partial and complete…”
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RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells by Li, Ningfeng Fiona, Gemenetzidis, Emilios, Marshall, Francis J, Davies, Derek, Yu, Yongwei, Frese, Kristopher, Froeling, Fieke E M, Woolf, Adam K, Feakins, Roger M, Naito, Yoshiki, Iacobuzio-Donahue, Christine, Tuveson, David A, Hart, Ian R, Kocher, Hemant M

“…Human pancreatic ductal adenocarcinoma (PDAC) is characterized by early systemic dissemination. Although RhoC has been implicated in cancer cell migration, the…”
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Uncaria tomentosa , the cat's whiskers or claws? by Froeling, Fieke E M, Stebbing, Justin

“…According to folklore, one of the plants containing good spirits is U tomentosa. Data presented at the 2014 annual meeting of the American Society of Clinical…”
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Ezrin Expression Is an Independent Prognostic Factor in Gastro-intestinal Cancers by Arumugam, Prabhu, Partelli, Stefano, Coleman, Stacey J., Cataldo, Ivana, Beghelli, Stefania, Bassi, Claudio, Wijesuriya, Nilukushi, Aleong, Jo-Anne Chin, Froeling, Fieke E. M., Scarpa, Aldo, Kocher, Hemant M.

“…Background Ezrin, a member of the ezrin–radixin–moesin (ERM) family of plasma membrane–cytoskeleton linker proteins, has been associated with metastatic…”
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Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution by Chan-Seng-Yue, Michelle, Kim, Jaeseung C., Wilson, Gavin W., Ng, Karen, Figueroa, Eugenia Flores, O’Kane, Grainne M., Connor, Ashton A., Denroche, Robert E., Grant, Robert C., McLeod, Jessica, Wilson, Julie M., Jang, Gun Ho, Zhang, Amy, Liang, Sheng-Ben, Borgida, Ayelet, Chadwick, Dianne, Kalimuthu, Sangeetha, Lungu, Ilinca, Bartlett, John M. S., Krzyzanowski, Paul M., Sandhu, Vandana, Tiriac, Hervé, Froeling, Fieke E. M., Karasinska, Joanna M., Topham, James T., Renouf, Daniel J., Schaeffer, David F., Jones, Steven J. M., Marra, Marco A., Laskin, Janessa, Chetty, Runjan, Stein, Lincoln D., Zogopoulos, George, Haibe-Kains, Benjamin, Campbell, Peter J., Tuveson, David A., Knox, Jennifer J., Fischer, Sandra E., Gallinger, Steven, Notta, Faiyaz

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Subtype switch foils pancreatic tumours by Froeling, Fieke, Tuveson, David

“…The authors also showed that the increase in the reach and activation of super-enhancers led to the activation of genes involved in squamous-subtype-like…”
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Pancreatic cancer foiled by a switch of tumour subtype by Froeling, Fieke, Tuveson, David

“…Mutations in the gene KDM6A drive an aggressive subtype of pancreatic cancer by causing repositioning of an enzyme complex that modifies histone proteins…”
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