Search Results - "Froehlich, John W"
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Determination of glycosylation sites and site-specific heterogeneity in glycoproteins
Published in Current opinion in chemical biology (01-10-2009)“…Glycosylation is one of the most common post-translational modifications (PTMs) of proteins. At least 50% of human proteins are glycosylated with some…”
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2
Consumption of Human Milk Oligosaccharides by Gut-Related Microbes
Published in Journal of agricultural and food chemistry (12-05-2010)“…Human milk contains large amounts of complex oligosaccharides that putatively modulate the intestinal microbiota of breast-fed infants by acting as decoy…”
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3
Half-Life of Serum Elimination of Perfluorooctanesulfonate, Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
Published in Environmental health perspectives (01-09-2007)“…Background: The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and…”
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4
Glycosylation of Human Milk Lactoferrin Exhibits Dynamic Changes During Early Lactation Enhancing Its Role in Pathogenic Bacteria-Host Interactions
Published in Molecular & cellular proteomics (01-06-2012)“…Human milk lactoferrin (hmLF) is the most abundant glycoprotein present in human milk and displays a broad range of protective functions in the gut of newborn…”
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5
Dual Modifications Strategy to Quantify Neutral and Sialylated N‑Glycans Simultaneously by MALDI-MS
Published in Analytical chemistry (Washington) (01-07-2014)“…Differences in ionization efficiency among neutral and sialylated glycans prevent direct quantitative comparison by their respective mass spectrometric…”
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Association between urinary biomarkers MMP-7/TIMP-2 and reduced renal function in children with ureteropelvic junction obstruction
Published in PloS one (14-07-2022)“…Extracellular matrix proteins and enzymes involved in degradation have been found to be associated with tissue fibrosis and ureteropelvic junction obstruction…”
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Comparison of human whole blood, plasma, and serum matrices for the determination of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other fluorochemicals
Published in Environmental research (01-02-2007)“…Interest in human exposure to perfluorinated acids, including perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHS), perfluorooctanesulfonate…”
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Identification of novel non‐invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Published in BJU international (01-07-2017)“…Objective To examine a series of candidate markers for urological chronic pelvic pain syndrome (UCPPS), selected based on their proposed involvement in…”
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9
Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
Published in Toxicology (Amsterdam) (20-01-2008)“…Abstract Introduction Perfluorooctanesulfonate (PFOS) is widely distributed and persistent in humans and wildlife. Prior toxicological studies have reported…”
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10
A Classifier Based on Accurate Mass Measurements to Aid Large Scale, Unbiased Glycoproteomics
Published in Molecular & cellular proteomics (01-04-2013)“…Determining which glycan moieties occupy specific N-glycosylation sites is a highly challenging analytical task. Arguably, the most common approach involves…”
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An in-depth Comparison of the Pediatric and Adult Urinary N-glycomes
Published in Molecular & cellular proteomics (01-11-2020)“…The urinary N-glycome can reflect systemic and urogenital physiology. We performed the first in-depth characterization and comparison of the pediatric and…”
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12
Uromodulin Isolation and Its N‑Glycosylation Analysis by NanoLC-MS/MS
Published in Journal of proteome research (07-05-2021)“…The glycoprotein uromodulin (UMOD) is the most abundant protein in urine, and N-glycans are critical for many biological functions of UMOD. Comprehensive…”
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The Urinary Proteomic Profile Implicates Key Regulators for Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Research Network Study
Published in Molecular & cellular proteomics (01-01-2022)“…Urologic chronic pelvic pain syndrome (UCPPS) is a condition of unknown etiology characterized by pelvic pain and urinary frequency and/or urgency. As the…”
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14
Proteomic Discovery of Noninvasive Biomarkers Associated With Sport-Related Concussions
Published in Neurology (11-01-2022)“…Sport-related concussions affect millions of individuals across the United States each year, and current techniques to diagnose and monitor them rely largely…”
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A Normative Study of the Synovial Fluid Proteome from Healthy Porcine Knee Joints
Published in Journal of proteome research (03-10-2014)“…Synovial fluid in an articulating joint contains proteins derived from the blood plasma and proteins that are produced by cells within the joint tissues, such…”
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The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment
Published in Molecular & cellular proteomics (01-10-2013)“…Current strategies to study N-glycoproteins in complex samples are often discrete, focusing on either N-glycans or N-glycosites enriched by sugar-based…”
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Characterizing Patients with Recurrent Urinary Tract Infections in Vesicoureteral Reflux: A Pilot Study of the Urinary Proteome
Published in Molecular & cellular proteomics (01-03-2020)“…Recurrent urinary tract infections (UTIs) are a significant burden to the health care system, with little insight into underlying mechanisms. Urinary proteomes…”
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Urinary Proteomics Yield Pathological Insights for Ureteropelvic Junction Obstruction
Published in Molecular & cellular proteomics (01-08-2016)“…Prenatal hydronephrosis is a common condition that may spontaneously resolve after birth. However, this condition can result in renal damage and requires…”
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Glycoprotein Expression in Human Milk during Lactation
Published in Journal of agricultural and food chemistry (26-05-2010)“…While milk proteins have been studied for decades, strikingly little effort has been applied to determining how the post-translational modifications (PTMs) of…”
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An in-depth comparison of the male pediatric and adult urinary proteomes
Published in Biochimica et biophysica acta (01-05-2014)“…In this study, we performed an in-depth characterization of the male pediatric infant urinary proteome by parallel proteomic analysis of normal healthy adult…”
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