Search Results - "Froehlich, Bjoern C."

MS visualization and interpretation software (MS‐VIS), a tool for visualizing mass spectra and analysing mass lists by Froehlich, Bjoern C., Gill, Hardeep Kevin, Joshi, Anuj, Goodlett, David R.

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Using Two Peptide Isotopologues as Internal Standards for the Streamlined Quantification of Low-Abundance Proteins by Immuno-MRM and Immuno-MALDI by Ibrahim, Sahar, Froehlich, Bjoern C, Aguilar-Mahecha, Adriana, Aloyz, Raquel, Poetz, Oliver, Basik, Mark, Batist, Gerald, Zahedi, René P, Borchers, Christoph H

“…Mass spectrometry (MS), particularly targeted proteomics, is increasingly being used for quantifying specific proteins and peptides in clinical specimens. The…”
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mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours by Sobsey, Constance A, Froehlich, Bjoern C, Mitsa, Georgia, Ibrahim, Sahar, Popp, Robert, Zahedi, Rene P, de Bruin, Elza C, Borchers, Christoph H, Batist, Gerald

“…Capivasertib is a potent selective inhibitor of AKT. It was recently FDA-approved in combination with fulvestrant to treat HR+, HER2-negative breast cancers…”
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Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells by Froehlich, Bjoern C., Popp, Robert, Sobsey, Constance A., Ibrahim, Sahar, LeBlanc, Andre M., Mohammed, Yassene, Aguilar‐Mahecha, Adriana, Poetz, Oliver, Chen, Michael X., Spatz, Alan, Basik, Mark, Batist, Gerald, Zahedi, René P., Borchers, Christoph H.

“…Purpose Immuno‐MALDI (iMALDI) combines immuno‐enrichment of biomarkers with MALDI‐MS for fast, precise, and specific quantitation, making it a valuable tool…”
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Label-free assessment of complement-dependent cytotoxicity of therapeutic antibodies via a whole-cell MALDI mass spectrometry bioassay by Schmidt, Stefan, Geisel, Alexander, Enzlein, Thomas, Fröhlich, Björn C., Pritchett, Louise, Verneret, Melanie, Graf, Christian, Hopf, Carsten

“…Potency assessment of monoclonal antibodies or corresponding biosimilars in cell-based assays is an essential prerequisite in biopharmaceutical research and…”
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Abstract B21: Protein quantitation assays for Akt, PI3K p110α, and PTEN to assess PI3K pathway activity in tumor tissue by Sobsey, Constance A., Popp, Robert, Ibrahim, Sahar, Froehlich, Bjoern C, Aguilar-Mahecha, Adriana, Basik, Mark, Batist, Gerald, Borchers, Christoph

“…Abstract Introduction: Many clinical trials for inhibitors targeting the PI3K pathway now include genetic screening of tumors to try to select probable…”
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Front Cover: Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells by Froehlich, Bjoern C., Popp, Robert, Sobsey, Constance A., Ibrahim, Sahar, LeBlanc, Andre M., Mohammed, Yassene, Aguilar‐Mahecha, Adriana, Poetz, Oliver, Chen, Michael X., Spatz, Alan, Basik, Mark, Batist, Gerald, Zahedi, René P., Borchers, Christoph H.

“…Automated immuno‐MALDI workflow for the quantitation of protein biomarker concentrations in clinical samples. Automation protocols for each liquid handling…”
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