Search Results - "Frode Norheim"

Progress and Challenges in the Biology of FNDC5 and Irisin by Maak, Steffen, Norheim, Frode, Drevon, Christian A, Erickson, Harold P

“…Abstract In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually…”
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Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men by Lee, Sindre, Gulseth, Hanne L., Langleite, Torgrim M., Norheim, Frode, Olsen, Thomas, Refsum, Helga, Jensen, Jørgen, Birkeland, Kåre I., Drevon, Christian A.

“…Aims/hypothesis Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired BCAA…”
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Irisin – a myth rather than an exercise-inducible myokine by Albrecht, Elke, Norheim, Frode, Thiede, Bernd, Holen, Torgeir, Ohashi, Tomoo, Schering, Lisa, Lee, Sindre, Brenmoehl, Julia, Thomas, Selina, Drevon, Christian A., Erickson, Harold P., Maak, Steffen

“…The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5) and to mediate beneficial effects…”
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Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2 null mice by Doncheva, Atanaska I., Li, Yuchuan, Khanal, Prabhat, Hjorth, Marit, Kolset, Svein O., Norheim, Frode A., Kimmel, Alan R., Dalen, Knut Tomas

“…Perilipin 2 (Plin2) binds to the surface of hepatic lipid droplets (LDs) with expression levels that correlate with triacylglyceride (TAG) content. We…”
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The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells by Tingstad, Ragna H., Norheim, Frode, Haugen, Fred, Feng, Yuan Z., Tunsjø, Hege S., Thoresen, G. Hege, Rustan, Arild C., Charnock, Colin, Aas, Vigdis

“…Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes…”
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Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis by Lee-Ødegård, Sindre, Hjorth, Marit, Olsen, Thomas, Moen, Gunn-Helen, Daubney, Emily, Evans, David M, Hevener, Andrea L, Lusis, Aldons J, Zhou, Mingqi, Seldin, Marcus M, Allayee, Hooman, Hilser, James, Viken, Jonas Krag, Gulseth, Hanne, Norheim, Frode, Drevon, Christian A, Birkeland, Kåre Inge

“…Physical activity has been associated with preventing the development of type 2 diabetes and atherosclerotic cardiovascular disease. However, our understanding…”
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Mechanisms Behind NAFLD: a System Genetics Perspective by Pourteymour, Shirin, Drevon, Christian A., Dalen, Knut Tomas, Norheim, Frode A.

“…Purpose of Review To summarize the key factors contributing to the onset and progress of nonalcoholic fatty liver disease (NAFLD) and put them in a system…”
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Evidence against a beneficial effect of irisin in humans by Raschke, Silja, Elsen, Manuela, Gassenhuber, Hans, Sommerfeld, Mark, Schwahn, Uwe, Brockmann, Barbara, Jung, Raphael, Wisløff, Ulrik, Tjønna, Arnt E, Raastad, Truls, Hallén, Jostein, Norheim, Frode, Drevon, Christian A, Romacho, Tania, Eckardt, Kristin, Eckel, Juergen

“…Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from…”
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Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits by Norheim, Frode, Hasin-Brumshtein, Yehudit, Vergnes, Laurent, Chella Krishnan, Karthickeyan, Pan, Calvin, Seldin, Marcus M., Hui, Simon T., Mehrabian, Margarete, Zhou, Zhiqiang, Gupta, Sonul, Parks, Brian W., Walch, Axel, Reue, Karen, Hofmann, Susanna M., Arnold, Arthur P., Lusis, Aldons J.

“…We studied sex differences in over 50 cardio-metabolic traits in a panel of 100 diverse inbred strains of mice. The results clearly showed that the effects of…”
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Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice by Parks, Brian W., Nam, Elizabeth, Org, Elin, Kostem, Emrah, Norheim, Frode, Hui, Simon T., Pan, Calvin, Civelek, Mete, Rau, Christoph D., Bennett, Brian J., Mehrabian, Margarete, Ursell, Luke K., He, Aiqing, Castellani, Lawrence W., Zinker, Bradley, Kirby, Mark, Drake, Thomas A., Drevon, Christian A., Knight, Rob, Gargalovic, Peter, Kirchgessner, Todd, Eskin, Eleazar, Lusis, Aldons J.

“…Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS)…”
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Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study by Olsen, Thomas, Øvrebø, Bente, Haj-Yasein, Nadia, Lee, Sindre, Svendsen, Karianne, Hjorth, Marit, Bastani, Nasser E, Norheim, Frode, Drevon, Christian A, Refsum, Helga, Vinknes, Kathrine J

“…Dietary restriction of methionine and cysteine is a well-described model that improves metabolic health in rodents. To investigate the translational potential…”
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The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits by Lusis, Aldons J., Seldin, Marcus M., Allayee, Hooman, Bennett, Brian J., Civelek, Mete, Davis, Richard C., Eskin, Eleazar, Farber, Charles R., Hui, Simon, Mehrabian, Margarete, Norheim, Frode, Pan, Calvin, Parks, Brian, Rau, Christoph D., Smith, Desmond J., Vallim, Thomas, Wang, Yibin, Wang, Jessica

“…The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic…”
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Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training by Norheim, Frode, Raastad, Truls, Thiede, Bernd, Rustan, Arild C, Drevon, Christian A, Haugen, Fred

“…Regular physical activity protects against several types of diseases. This may involve altered secretion of signaling proteins from skeletal muscle. Our aim…”
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Genetic Architecture of Insulin Resistance in the Mouse by Parks, Brian W., Sallam, Tamer, Mehrabian, Margarete, Psychogios, Nikolas, Hui, Simon T., Norheim, Frode, Castellani, Lawrence W., Rau, Christoph D., Pan, Calvin, Phun, Jennifer, Zhou, Zhenqi, Yang, Wen-Pin, Neuhaus, Isaac, Gargalovic, Peter S., Kirchgessner, Todd G., Graham, Mark, Lee, Richard, Tontonoz, Peter, Gerszten, Robert E., Hevener, Andrea L., Lusis, Aldons J.

“…Insulin resistance (IR) is a complex trait with multiple genetic and environmental components. Confounded by large differences between the sexes, environment,…”
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Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice by Hjorth, Marit, Doncheva, Atanaska, Norheim, Frode, Ulven, Stine Marie, Holven, Kirsten Bjørklund, Sæther, Thomas, Dalen, Knut Tomas

“…Purpose By-products from farmed fish contain large amounts of proteins and may be used for human consumption. The purpose of this study was to investigate…”
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Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis by Norheim, Frode, Chella Krishnan, Karthickeyan, Bjellaas, Thomas, Vergnes, Laurent, Pan, Calvin, Parks, Brian W, Meng, Yonghong, Lang, Jennifer, Ward, James A, Reue, Karen, Mehrabian, Margarete, Gundersen, Thomas E, Péterfy, Miklós, Dalen, Knut T, Drevon, Christian A, Hui, Simon T, Lusis, Aldons J, Seldin, Marcus M

“…To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic…”
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The genetic architecture of NAFLD among inbred strains of mice by Hui, Simon T, Parks, Brian W, Org, Elin, Norheim, Frode, Che, Nam, Pan, Calvin, Castellani, Lawrence W, Charugundla, Sarada, Dirks, Darwin L, Psychogios, Nikolaos, Neuhaus, Isaac, Gerszten, Robert E, Kirchgessner, Todd, Gargalovic, Peter S, Lusis, Aldons J

“…To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related…”
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Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex by Li, Yuchuan, Khanal, Prabhat, Norheim, Frode, Hjorth, Marit, Bjellaas, Thomas, Drevon, Christian A., Vaage, Jarle, Kimmel, Alan R., Dalen, Knut Tomas

“…Cholesteryl esters (CEs) are the water-insoluble transport and storage form of cholesterol. Steroidogenic cells primarily store CEs in cytoplasmic lipid…”
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity by Doncheva, Atanaska I, Norheim, Frode A, Hjorth, Marit, Grujic, Mirjana, Paivandy, Aida, Dankel, Simon N, Hertel, Jens Kristoffer, Valderhaug, Tone G, Böttcher, Yvonne, Fernø, Johan, Mellgren, Gunnar, Dalen, Knut T, Pejler, Gunnar, Kolset, Svein O

“…Chronic local inflammation of adipose tissue is an important feature of obesity. Serglycin is a proteoglycan highly expressed by various immune cell types…”
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The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice by Hui, Simon T., Kurt, Zeyneb, Tuominen, Iina, Norheim, Frode, C.Davis, Richard, Pan, Calvin, Dirks, Darwin L., Magyar, Clara E., French, Samuel W., Chella Krishnan, Karthickeyan, Sabir, Simon, Campos‐Pérez, Francisco, Méndez‐Sánchez, Nahum, Macías‐Kauffer, Luis, León‐Mimila, Paola, Canizales‐Quinteros, Samuel, Yang, Xia, Beaven, Simon W., Huertas‐Vazquez, Adriana, Lusis, Aldons J.

“…We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying…”
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