Search Results - "Frölich, Jürgen C."

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia by Savvidou, Makrina D, Hingorani, Aroon D, Tsikas, Dimitrios, Frölich, Jürgen C, Vallance, Patrick, Nicolaides, Kypros H

“…Maternal endothelial dysfunction is a feature of established pre-eclampsia but whether this is a cause or consequence of the disorder is not clear. We tested…”
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Nitrosative stress does not change during orthotopic liver transplantation by Tsikas, Dimitrios, Frölich, Jürgen C., Klempnauer, Jürgen, Becker, Thomas

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Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS by Tsikas, Dimitrios, Stichtenoth, Dirk O., Staerk, Ulrich, Probst, Irmelin, Suchy, Maria-Theresia, Böhmer, Anke, Trettin, Arne, Frölich, Jürgen C.

“…Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX),…”
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Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox by Tsikas, Dimitrios, Böger, Rainer H, Sandmann, Jörg, Bode-Böger, Stefanie M, Frölich, Jürgen C

“…L-Arginine, the substrate of nitric oxide (NO) synthases (NOSs), is found in the mammalian organism at concentrations by far exceeding K M values of these…”
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Simplified HPLC method for urinary and circulating creatinine by Tsikas, Dimitrios, Wolf, Alexander, Frölich, Jürgen C

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Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease by BÖGER, R. H, BODE-BÖGER, S. M, THIELE, W, JUNKER, W, ALEXANDER, K, FRÖLICH, J. C

“…We studied urinary nitrate and cGMP excretion rates, indices of systemic NO formation, and plasma concentrations of L-arginine and the endogenous NO synthase…”
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Oral L-arginine improves endothelial function in healthy individuals older than 70 years by Bode-Böger, Stefanie M, Muke, Jochen, Surdacki, Andrzej, Brabant, Georg, Böger, Rainer H, Frölich, Jürgen C

“…Ageing is associated with progressive endothelial dysfunction in normal humans. Flow-mediated dilation (FMD) of the brachial artery is impaired in elderly…”
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Development, validation and biomedical applications of stable-isotope dilution GC–MS and GC–MS/MS techniques for circulating malondialdehyde (MDA) after pentafluorobenzyl bromide derivatization: MDA as a biomarker of oxidative stress and its relation to 15(S)-8-iso-prostaglandin F2α and nitric oxide (NO) by Tsikas, Dimitrios, Rothmann, Sabine, Schneider, Jessica Y., Suchy, Maria-Theresia, Trettin, Arne, Modun, Darko, Stuke, Nadine, Maassen, Norbert, Frölich, Jürgen C.

“…•Malondialdehyde (MDA) is a popular oxidative stress biomarker.•We report a unique derivatization of MDA with pentafluorobenzyl bromide.•Deuterium-labelled MDA…”
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Simultaneous GC-MS/MS measurement of malondialdehyde and 4-hydroxy-2-nonenal in human plasma: Effects of long-term L-arginine administration by Tsikas, Dimitrios, Rothmann, Sabine, Schneider, Jessica Y., Gutzki, Frank-Mathias, Beckmann, Bibiana, Frölich, Jürgen C.

“…Here, we report the simultaneous derivatization and quantification of malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) in human plasma by GC-MS/MS using…”
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Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line by Thum, Thomas, Tsikas, Dimitris, Frölich, Jürgen C, Borlak, Jürgen

“…Growth hormone deficiency is linked to cardiovascular disease and particularly increased peripheral vascular resistance. Surprisingly, its role in endothelial…”
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L‐arginine‐induced vasodilation in healthy humans:pharmacokinetic–pharmacodynamic relationship by Bode‐Böger, Stefanie M., Böger, Rainer H., Galland, Andrea, Tsikas, Dimitrios, Frölich, Jürgen C.

“…Aims Administration of l‐arginine by intravenous infusion or via oral absorption has been shown to induce peripheral vasodilation in humans, and to improve…”
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S-Nitrosoalbumin Plasma Levels in Health and Disease: Facts or Artifacts? Value of Analytical Chemistry in Nitric Oxide Clinical Research by Tsikas, Dimitrios, Frölich, Jürgen C

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Methodological Considerations on the Detection of 3-Nitrotyrosine in the Cardiovascular System by Tsikas, Dimitrios, Schwedhelm, Edzard, Frölich, Jürgen C

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ADMA (asymmetric dimethylarginine): an atherosclerotic disease mediating agent in patients with renal disease? by Kielstein, Jan T., Frölich, Jürgen C., Haller, Hermann, Fliser, Danilo

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Glutathione promotes prostaglandin H synthase (cyclooxygenase)-dependent formation of malondialdehyde and 15(S)-8-iso-prostaglandin F2α by Tsikas, Dimitrios, Suchy, Maria-Theresia, Niemann, Jonas, Tossios, Paschalis, Schneider, Yessica, Rothmann, Sabine, Gutzki, Frank-Mathias, Frölich, Jürgen C., Stichtenoth, Dirk O.

“…► Cyclooxygenases (COX) convert arachidonic acid to MDA and 15(S)-8-iso-PGF2α. ► Glutathione (GSH) promotes COX-dependent MDA and 15(S)-8-iso-PGF2α formation…”
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Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans by Kayacelebi, Arslan Arinc, Langen, Jennifer, Weigt-Usinger, Katharina, Chobanyan-Jürgens, Kristine, Mariotti, François, Schneider, Jessica Y, Rothmann, Sabine, Frölich, Jürgen C, Atzler, Dorothee, Choe, Chi-un, Schwedhelm, Edzard, Huneau, Jean François, Lücke, Thomas, Tsikas, Dimitrios

“…Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis, whereas L-arginine (Arg) and L-homoarginine (hArg) serve as…”
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Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography–tandem mass spectrometry by Tsikas, Dimitrios, Schwedhelm, Edzard, Stutzer, Friedericke K, Gutzki, Frank-Mathias, Rode, Iris, Mehls, Christina, Frölich, Jürgen C

“…Measurement of 3-nitro- l-tyrosine (NO 2Tyr) and protein-related 3-nitro- l-tyrosine in human plasma is associated with numerous methodological problems which…”
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Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease by Kayacelebi, Arslan Arinc, Willers, Janina, Pham, Vu Vi, Hahn, Andreas, Schneider, Jessica Y, Rothmann, Sabine, Frölich, Jürgen C, Tsikas, Dimitrios

“…Elevated circulating concentrations of total L-homocysteine (thCys) and free asymmetric dimethylarginine (ADMA) are long-established cardiovascular risk…”
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Urinary 8-iso-prostaglandin F2α as a risk marker in patients with coronary heart disease: A matched case-control study by SCHWEDHELM, Edzard, BARTLING, Asja, LENZEN, Henrike, TSIKAS, Dimitrios, MAAS, Renke, BRÜMMER, Jens, GUTZKI, Frank-Mathias, BERGER, Jürgen, FRÖLICH, Jürgen C, BÖGER, Rainer H

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Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings by Tsikas, Dimitrios, Hanff, Erik, Bollenbach, Alexander, Kruger, Ruan, Pham, Vu Vi, Chobanyan-Jürgens, Kristine, Wedekind, Dirk, Arndt, Tanja, Jörns, Anne, Berbée, Jimmy F. P., Princen, Hans M. G., Lücke, Thomas, Mariotti, François, Huneau, Jean-François, Ückert, Stefan, Frölich, Jürgen C., Lenzen, Sigurd

“…We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO 2 − ), an abundant reservoir of nitric oxide (NO)…”
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