Search Results - "Fritz, Gerhard"

Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death by Aengenvoort, Jana, Sekeres, Marlena, Proksch, Peter, Fritz, Gerhard

“…Recently, we identified secalonic acid F (SA), 5-epi-nakijiquinone Q (NQ) and 5-epi-ilimaquinone (IQ) as natural compounds (NC) affecting mechanisms of the DNA…”
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Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42 by Kücük, Pelin, Abbey, Lena, Schmitt, Joachim, Henninger, Christian, Fritz, Gerhard

“…The clinical use of the DNA damaging anticancer drug doxorubicin (DOX) is limited by irreversible cardiotoxicity, which depends on the cumulative dose. The…”
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Metal-Organic Frameworks in Monolithic Structures by Küsgens, Pia, Zgaverdea, Alina, Fritz, Hans-Gerhard, Siegle, Sven, Kaskel, Stefan

“…For the first time, the manufacturing of metal‐organic framework‐based monoliths using a two‐step process is reported. In a first experiment, the in situ…”
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Rho GTPases: Novel Players in the Regulation of the DNA Damage Response? by Fritz, Gerhard, Henninger, Christian

“…The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound…”
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Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans by Jahn, Andreas, Scherer, Bo, Fritz, Gerhard, Honnen, Sebastian

“…Statins belong to the most pre-scribed cholesterol lowering drugs in western countries. Their competitive inhibition of the HMG-CoA reductase causes a…”
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Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer by Ziegler, Verena, Deußen, Marco, Schumacher, Lena, Roos, Wynand P., Fritz, Gerhard

“…The endothelium contributes to the pathophysiology of adverse effects caused by conventional (genotoxic) anticancer therapeutics (cAT). The relevance of…”
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Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression by Hanisch, Daniela, Krumm, Andrea, Diehl, Tamara, Stork, Carla M., Dejung, Mario, Butter, Falk, Kim, Ella, Brenner, Walburgis, Fritz, Gerhard, Hofmann, Thomas G., Roos, Wynand P.

“…Overexpression of histone deacetylases (HDACs) in cancer commonly causes resistance to genotoxic-based therapies. Here, we report on the novel mechanism…”
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Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16 by Büchter, Christian, Ackermann, Daniela, Havermann, Susannah, Honnen, Sebastian, Chovolou, Yvonni, Fritz, Gerhard, Kampkötter, Andreas, Wätjen, Wim

“…Myricetin is a naturally occurring flavonol found in many plant based food sources. It increases the lifespan of Caenorhabditis elegans, but the molecular…”
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Rho GTPases: promising cellular targets for novel anticancer drugs by Fritz, Gerhard, Kaina, Bernd

“…Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho…”
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HMG-CoA reductase inhibitors (statins) as anticancer drugs (review) by Fritz, Gerhard

“…Apart from their lipid lowering activity, HMG-CoA reductase inhibitors (statins) impair numerous cellular functions associated with metastasis, e.g. gene…”
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Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons by Huelsenbeck, Stefanie C., Schorr, Anne, Roos, Wynand P., Huelsenbeck, Johannes, Henninger, Christian, Kaina, Bernd, Fritz, Gerhard

“…To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation…”
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Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans by Nicolai, Merle M, Weishaupt, Ann-Kathrin, Baesler, Jessica, Brinkmann, Vanessa, Wellenberg, Anna, Winkelbeiner, Nicola, Gremme, Anna, Aschner, Michael, Fritz, Gerhard, Schwerdtle, Tanja, Bornhorst, Julia

“…Although manganese (Mn) is an essential trace element, overexposure is associated with Mn-induced toxicity and neurological dysfunction. Even though Mn-induced…”
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Warpage and countermeasure for injection-molded in-mold labeling parts by Larpsuriyakul, Patcharee, Fritz, Hans-Gerhard

“…Decades ago, the production of packaging with the injection in‐mold labeling (IML) has been established. With this manufacturing technique, label and…”
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In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi) by Friedrich, Annabelle, Assmann, Ann-Sophie, Schumacher, Lena, Stuijvenberg, Jana V, Kassack, Matthias U, Schulz, Wolfgang A, Roos, Wynand P, Hansen, Finn K, Pflieger, Marc, Kurz, Thomas, Fritz, Gerhard

“…Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of…”
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Electrosteric Stabilization of Colloidal Dispersions by Fritz, Gerhard, Schädler, Volker, Willenbacher, Norbert, Wagner, Norman J

“…The electrosteric stabilization of model colloidal dispersions is quantified through high-frequency rheometry and complementary techniques. Model aqueous…”
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Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors by Hamalukic, Melanie, Huelsenbeck, Johannes, Schad, Arno, Wirtz, Stefan, Kaina, Bernd, Fritz, Gerhard

“…Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the…”
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The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity by Henninger, Christian, Huelsenbeck, Johannes, Huelsenbeck, Stefanie, Grösch, Sabine, Schad, Arno, Lackner, Karl J., Kaina, Bernd, Fritz, Gerhard

“…Liver is the main detoxifying organ and therefore the target of high concentrations of genotoxic compounds, such as environmental carcinogens and anticancer…”
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In flagranti – Tötungsdelikte in der Ehe by Gerhard Fritz

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Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs) by Schmitt, Laura, Hoppe, Julia, Cea-Medina, Pablo, Bruch, Peter-Martin, Krings, Karina S., Lechtenberg, Ilka, Drießen, Daniel, Peter, Christoph, Bhatia, Sanil, Dietrich, Sascha, Stork, Björn, Fritz, Gerhard, Gohlke, Holger, Müller, Thomas J. J., Wesselborg, Sebastian

“…A key feature of cancer is the disruption of cell cycle regulation, which is characterized by the selective and abnormal activation of cyclin-dependent kinases…”
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Infrared Emitting and Photoconducting Colloidal Silver Chalcogenide Nanocrystal Quantum Dots from a Silylamide-Promoted Synthesis by Yarema, Maksym, Pichler, Stefan, Sytnyk, Mykhailo, Seyrkammer, Robert, Lechner, Rainer T, Fritz-Popovski, Gerhard, Jarzab, Dorota, Szendrei, Krisztina, Resel, Roland, Korovyanko, Oleksandra, Loi, Maria Antonietta, Paris, Oskar, Hesser, Günter, Heiss, Wolfgang

“…Here, we present a hot injection synthesis of colloidal Ag chalcogenide nanocrystals (Ag2Se, Ag2Te, and Ag2S) that resulted in exceptionally small nanocrystal…”
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