Search Results - "Fritz, Andrew J."

Chromosome territories and the global regulation of the genome by Fritz, Andrew J., Sehgal, Nitasha, Pliss, Artem, Xu, Jinhui, Berezney, Ronald

“…Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is organized as a hierarchy from nucleosomes to Mbp chromatin domains…”
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Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance by Zhou, Yufan, Gerrard, Diana L., Wang, Junbai, Li, Tian, Yang, Yini, Fritz, Andrew J., Rajendran, Mahitha, Fu, Xiaoyong, Stein, Gary, Schiff, Rachel, Lin, Shili, Frietze, Seth, Jin, Victor X.

“…Recent studies have demonstrated that chromatin architecture is linked to the progression of cancers. However, the roles of 3D structure and its dynamics in…”
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RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells by Fritz, Andrew J., Hong, Deli, Boyd, Joseph, Kost, Jason, Finstaad, Kristiaan H., Fitzgerald, Mark P., Hanna, Sebastian, Abuarqoub, Alqassem H., Malik, Miles, Bushweller, John, Tye, Coralee, Ghule, Prachi, Gordon, Jonathan, Frietze, Seth, Zaidi, Sayyed K., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are…”
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Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor by Hong, Deli, Fritz, Andrew J, Finstad, Kristiaan H, Fitzgerald, Mark P, Weinheimer, Adam, Viens, Adam L, Ramsey, Jon, Stein, Janet L, Lian, Jane B, Stein, Gary S

“…Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand…”
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RUNX1‐dependent mechanisms in biological control and dysregulation in cancer by Hong, Deli, Fritz, Andrew J., Gordon, Jonathan A., Tye, Coralee E., Boyd, Joseph R., Tracy, Kirsten M., Frietze, Seth E., Carr, Frances E., Nickerson, Jeffrey A., Wijnen, Andre J., Imbalzano, Anthony N., Zaidi, Sayyed K., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…The RUNX1 transcription factor has recently been shown to be obligatory for normal development. RUNX1 controls the expression of genes essential for proper…”
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SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells by Barutcu, A Rasim, Lajoie, Bryan R, Fritz, Andrew J, McCord, Rachel P, Nickerson, Jeffrey A, van Wijnen, Andre J, Lian, Jane B, Stein, Janet L, Dekker, Job, Stein, Gary S, Imbalzano, Anthony N

“…The packaging of DNA into chromatin plays an important role in transcriptional regulation and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as…”
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Selective expression of long non‐coding RNAs in a breast cancer cell progression model by Tracy, Kirsten M., Tye, Coralee E., Page, Natalie A., Fritz, Andrew J., Stein, Janet L., Lian, Jane B., Stein, Gary S.

“…Long non‐coding RNAs (lncRNAs) are acknowledged as regulators of cancer biology and pathology. Our goal was to perform a stringent profiling of breast cancer…”
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Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition by Hong, Deli, Messier, Terri L, Tye, Coralee E, Dobson, Jason R, Fritz, Andrew J, Sikora, Kenneth R, Browne, Gillian, Stein, Janet L, Lian, Jane B, Stein, Gary S

“…Runx1 is a well characterized transcription factor essential for hematopoietic differentiation and Runx1 mutations are the cause of leukemias. Runx1 is highly…”
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C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization by Barutcu, A. Rasim, Fritz, Andrew J., Zaidi, Sayyed K., van Wijnen, André J., Lian, Jane B., Stein, Janet L., Nickerson, Jeffrey A., Imbalzano, Anthony N., Stein, Gary S.

“…Three‐dimensional organization of the chromatin has important roles in transcription, replication, DNA repair, and pathologic events such as translocations…”
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Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus by Fritz, Andrew J., Barutcu, A. Rasim, Martin-Buley, Lori, van Wijnen, André J., Zaidi, Sayyed K., Imbalzano, Anthony N., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…ABSTRACT The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of…”
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Author Correction: Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance by Zhou, Yufan, Gerrard, Diana L., Wang, Junbai, Li, Tian, Yang, Yini, Fritz, Andrew J., Rajendran, Mahitha, Fu, Xiaoyong, Stein, Gary, Schiff, Rachel, Lin, Shili, Frietze, Seth, Jin, Victor X.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Cell type specific alterations in interchromosomal networks across the cell cycle by Fritz, Andrew J, Stojkovic, Branislav, Ding, Hu, Xu, Jinhui, Bhattacharya, Sambit, Berezney, Ronald

“…The interchromosomal organization of a subset of human chromosomes (#1, 4, 11, 12, 16, 17, and 18) was examined in G1 and S phase of human WI38 lung fibroblast…”
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Epithelial‐to‐mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity by Hong, Deli, Fritz, Andrew J., Zaidi, Sayyed K., Wijnen, Andre J., Nickerson, Jeffrey A., Imbalzano, Anthony N., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Breast cancer is the most common cancer in women, and accounts for ~30% of new cancer cases and 15% of cancer‐related deaths. Tumor relapse and metastasis are…”
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Identification of tRNA‐derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer by Farina, Nicholas H., Scalia, Stephanie, Adams, Caroline E., Hong, Deli, Fritz, Andrew J., Messier, Terri L., Balatti, Veronica, Veneziano, Dario, Lian, Jane B., Croce, Carlo M., Stein, Gary S., Stein, Janet L.

“…Despite recent advances in targeted therapies, the molecular mechanisms driving breast cancer initiation, progression, and metastasis are minimally understood…”
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Wide-scale alterations in interchromosomal organization in breast cancer cells: defining a network of interacting chromosomes by Fritz, Andrew J, Stojkovic, Branislav, Ding, Hu, Xu, Jinhui, Bhattacharya, Sambit, Gaile, Daniel, Berezney, Ronald

“…The interchromosomal spatial positionings of a subset of human chromosomes was examined in the human breast cell line MCF10A (10A) and its malignant…”
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Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression by Ghule, Prachi N., Boyd, Joseph R., Kabala, Fleur, Fritz, Andrew J., Bouffard, Nicole A., Gao, Cong, Bright, Kathleen, Macfarlane, Jill, Seward, David J., Pegoraro, Gianluca, Misteli, Tom, Lian, Jane B., Frietze, Seth, Stein, Janet L., van Wijnen, Andre J., Stein, Gary S.

“…•Histone gene clusters are organized in phase-separated Histone Locus Bodies (HLBs).•Higher-order chromatin at HLBs shows variable 3D organization during G1…”
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Corrigendum to “Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression” [Gene 872 (2023) 147441] by Ghule, Prachi N., Boyd, Joseph R., Kabala, Fleur, Fritz, Andrew J., Bouffard, Nicole A., Gao, Cong, Bright, Kathleen, Macfarlane, Jill, Seward, David J., Pegoraro, Gianluca, Misteli, Tom, Lian, Jane B., Frietze, Seth, Stein, Janet L., van Wijnen, Andre J., Stein, Gary S.

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Intranuclear and higher‐order chromatin organization of the major histone gene cluster in breast cancer by Fritz, Andrew J., Ghule, Prachi N., Boyd, Joseph R., Tye, Coralee E., Page, Natalie A., Hong, Deli, Shirley, David J., Weinheimer, Adam S., Barutcu, Ahmet R., Gerrard, Diana L., Frietze, Seth, van Wijnen, Andre J., Zaidi, Sayyed K., Imbalzano, Anthony N., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Alterations in nuclear morphology are common in cancer progression. However, the degree to which gross morphological abnormalities translate into compromised…”
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Large-scale probabilistic 3D organization of human chromosome territories by Sehgal, Nitasha, Fritz, Andrew J, Vecerova, Jaromira, Ding, Hu, Chen, Zihe, Stojkovic, Branislav, Bhattacharya, Sambit, Xu, Jinhui, Berezney, Ronald

“…There is growing evidence that chromosome territories (CT) have a probabilistic non-random arrangement within the cell nucleus of mammalian cells including…”
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Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S‐phase transition by Ghule, Prachi N., Seward, David J., Fritz, Andrew J., Boyd, Joseph R., van Wijnen, Andre J., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Fidelity of histone gene regulation, and ultimately of histone protein biosynthesis, is obligatory for packaging of newly replicated DNA into chromatin…”
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