Search Results - "Fritschy, JM"

Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study by Bohlhalter, S, Weinmann, O, Mohler, H, Fritschy, JM

“…To assess the significance of GABAA-receptor heterogeneity, which is based on a family of at least 15 subunits, the cellular localization and subunit…”
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Switch in the expression of rat GABAA-receptor subtypes during postnatal development: an immunohistochemical study by Fritschy, JM, Paysan, J, Enna, A, Mohler, H

“…The involvement of GABA in neuronal differentiation and maturation precedes its role as inhibitory neurotransmitter in the brain. It was therefore investigated…”
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Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications by Fritschy, Jean-Marc, Brünig, Ina

“…gamma-Aminobutyric acid(A) (GABA(A)) receptors mediate most of the fast inhibitory neurotransmission in the CNS. They represent a major site of action for…”
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Specific GABA A Circuits for Visual Cortical Plasticity by Fagiolini, Michela, Fritschy, Jean-Marc, Löw, Karin, Möhler, Hanns, Rudolph, Uwe, Hensch, Takao K.

“…Weak inhibition within visual cortex early in life prevents experience-dependent plasticity. Loss of responsiveness to an eye deprived of vision can be…”
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A new benzodiazepine pharmacology by Möhler, H, Fritschy, J M, Rudolph, U

“…Classical benzodiazepine drugs are in wide clinical use as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. They act by enhancing the…”
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Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice by Zeilhofer, Hanns Ulrich, Studler, Barbara, Arabadzisz, Dimitrula, Schweizer, Claude, Ahmadi, Seifollah, Layh, Beate, Bösl, Michael R., Fritschy, Jean-Marc

“…Although glycine is a major inhibitory transmitter in the mammalian CNS, the role of glycinergic neurons in defined neuronal circuits remains ill defined. This…”
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Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus by Arabadzisz, Dimitrula, Antal, Károly, Parpan, Franziska, Emri, Zsuzsa, Fritschy, Jean-Marc

“…Major aspects of temporal lobe epilepsy (TLE) can be reproduced in mice following a unilateral injection of kainic acid into the dorsal hippocampus. This…”
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Overexpression of Adenosine Kinase in Epileptic Hippocampus Contributes to Epileptogenesis by Gouder, Nicolette, Scheurer, Louis, Fritschy, Jean-Marc, Boison, Detlev

“…Endogenous adenosine in the brain is thought to prevent the development and spread of seizures via a tonic anticonvulsant effect. Brain levels of adenosine are…”
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Benzodiazepine actions mediated by specific γ-aminobutyric acid A receptor subtypes by Rudolph, Uwe, Crestani, Florence, Benke, Dietmar, Brünig, Ina, Benson, Jack A, Fritschy, Jean-Marc, Martin, James R, Bluethmann, Horst, Möhler, Hanns

“…GABAA (γ-aminobutyric acidA) receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity and memory…”
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The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses by Schweizer, Claude, Balsiger, Sylvia, Bluethmann, Horst, Mansuy, Isabelle M, Fritschy, Jean-Marc, Mohler, Hanns, Lüscher, Bernhard

“…The gamma2 subunit of GABA(A) receptor chloride channels is required for normal channel function and for postsynaptic clustering of these receptors during…”
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Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures by Kralic, Jason E., Ledergerber, Debora A., Fritschy, Jean-Marc

“…Adult hippocampal neurogenesis is enhanced in response to multiple stimuli including seizures. However, the relationship between neurogenesis and the…”
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Intact sorting, targeting, and clustering of γ-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro by Brünig, Ina, Scotti, Eleonora, Sidler, Corinne, Fritschy, Jean-Marc

“…The cellular and subcellular distribution of four GABAA receptor subtypes, identified by the presence of the α1, α2, α3, or α5 subunit, was investigated…”
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Synapse-specific localization of NMDA and GABA(A) receptor subunits revealed by antigen-retrieval immunohistochemistry by Fritschy, J M, Weinmann, O, Wenzel, A, Benke, D

“…Conventional immunohistochemistry provides little evidence for the synaptic localization of ionotropic neurotransmitter receptors, suggesting that their…”
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Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier by Soontornmalai, A., Vlaming, M.L.H., Fritschy, J.-M.

“…Multidrug transporters of the ATP-binding cassette family play an important role in regulating drug distribution and efflux in the brain, owing to their…”
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Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety by Löw, Karin, Crestani, Florence, Keist, Ruth, Benke, Dietmar, Brünig, Ina, Benson, Jack A., Fritschy, Jean-Marc, Rülicke, Thomas, Bluethmann, Horst, Möhler, Hanns, Rudolph, Uwe

“…Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the molecular and neuronal target mediating the anxiolytic action of…”
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Reciprocal Alterations in Pre- and Postsynaptic Inhibitory Markers at Chandelier Cell Inputs to Pyramidal Neurons in Schizophrenia by Volk, David W., Pierri, Joseph N., Fritschy, Jean-Marc, Auh, Sungyoung, Sampson, Allan R., Lewis, David A.

“…In the prefrontal cortex of subjects with schizophrenia, markers of the synthesis and re-uptake of GABA appear to be selectively altered in a subset of…”
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Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy by Riban, V., Bouilleret, V., Pham-Lê, B.T., Fritschy, J.-M., Marescaux, C., Depaulis, A.

“…Unilateral intrahippocampal injection of kainic acid in adult mice reproduces most of the morphological characteristics of hippocampal sclerosis (neuronal…”
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BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA(A) receptor surface expression by Brünig, I, Penschuck, S, Berninger, B, Benson, J, Fritschy, J M

“…Changes in neurotransmitter receptor density at the synapse have been proposed as a mechanism underlying synaptic plasticity. Neurotrophic factors are known to…”
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Selective Alterations in GABA A Receptor Subtypes in Human Temporal Lobe Epilepsy by Loup, Fabienne, Wieser, Heinz-Gregor, Yonekawa, Yasuhiro, Aguzzi, Adriano, Fritschy, Jean-Marc

“…Temporal lobe epilepsy (TLE) is associated with impaired inhibitory neurotransmission. Studies in animal models suggest that GABA A receptor dysfunction…”
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Functional mapping of GABA A receptor subtypes in the amygdala by Marowsky, Anne, Fritschy, Jean-Marc, Vogt, Kaspar E

“…The physiological significance of the large diversity of GABA A receptors is poorly understood. Using mice, which carry a point mutation that renders specific…”
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