Search Results - "Fritschy, J"

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism by Marowsky, A, Burgener, J, Falck, J.R, Fritschy, J.-M, Arand, M

“…Abstract Epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic…”
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Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue by Haenggi, T, Fritschy, J-M

“…The dystrophin glycoprotein complex (DGC) is a multimeric protein assembly associated with either the X-linked cytoskeletal protein dystrophin or its autosomal…”
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Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier by Soontornmalai, A., Vlaming, M.L.H., Fritschy, J.-M.

“…Multidrug transporters of the ATP-binding cassette family play an important role in regulating drug distribution and efflux in the brain, owing to their…”
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Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy by Riban, V., Bouilleret, V., Pham-Lê, B.T., Fritschy, J.-M., Marescaux, C., Depaulis, A.

“…Unilateral intrahippocampal injection of kainic acid in adult mice reproduces most of the morphological characteristics of hippocampal sclerosis (neuronal…”
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A new benzodiazepine pharmacology by Möhler, H, Fritschy, J M, Rudolph, U

“…Classical benzodiazepine drugs are in wide clinical use as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. They act by enhancing the…”
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Trace fear conditioning involves hippocampal α5 GABAA receptors by Crestani, F., Keist, R., Fritschy, J.-M., Benke, D., Vogt, K., Prut, L., Blüthmann, H., Möhler, H., Rudolph, U.

“…The heterogeneity of γ-aminobutyric acid type A (GABA A ) receptors contributes to the diversity of neuronal inhibition in the regulation of information…”
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Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety by Löw, Karin, Crestani, Florence, Keist, Ruth, Benke, Dietmar, Brünig, Ina, Benson, Jack A., Fritschy, Jean-Marc, Rülicke, Thomas, Bluethmann, Horst, Möhler, Hanns, Rudolph, Uwe

“…Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the molecular and neuronal target mediating the anxiolytic action of…”
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A schizophrenia-related sensorimotor deficit links α3-containing GABAA receptors to a dopamine hyperfunction by Yee, B. K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R. C., Fritschy, J.-M., Bluethmann, H., Feldon, J., Möhler, H., Rudolph, U.

“…Overactivity of the dopaminergic system in the brain is considered to be a contributing factor to the development and symptomatology of schizophrenia…”
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Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme by Studer, F.E., Fedele, D.E., Marowsky, A., Schwerdel, C., Wernli, K., Vogt, K., Fritschy, J.M., Boison, D.

“…Adenosine is a potent modulator of excitatory neurotransmission, especially in seizure-prone regions such as the hippocampal formation. In adult brain ambient…”
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Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition by Simon, C., Stieger, B., Kullak-Ublick, G. A., Fried, M., Mueller, S., Fritschy, J.-M., Wieser, H.G., Pauli-Magnus, C.

“…Objectives –  Interindividual variability in intestinal absorption and bioavailability might contribute to inadequate control of seizures under treatment with…”
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Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior by Zheng, F, Adelsberger, H, Müller, M R, Fritschy, J-M, Werner, S, Alzheimer, C

“…Activin, a member of the transforming growth factor-β superfamily, affords neuroprotection in acute brain injury, but its physiological functions in normal…”
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A reduction in hippocampal GABAA receptor α5 subunits disrupts the memory for location of objects in mice by Prut, L., Prenosil, G., Willadt, S., Vogt, K., Fritschy, J.‐M., Crestani, F.

“…The memory for location of objects, which binds information about objects to discrete positions or spatial contexts of occurrence, is a form of episodic memory…”
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Intact sorting, targeting, and clustering of γ-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro by Brünig, Ina, Scotti, Eleonora, Sidler, Corinne, Fritschy, Jean-Marc

“…The cellular and subcellular distribution of four GABAA receptor subtypes, identified by the presence of the α1, α2, α3, or α5 subunit, was investigated…”
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Cellular Localization of GABAA Receptor α Subunit Immunoreactivity in the Rat Hypothalamus: Relationship With Neurones Containing Orexigenic or Anorexigenic Peptides by Bäckberg, M., Ultenius, C., Fritschy, J.-M., Meister, B.

“…γ‐Aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, acts via two different type of GABA receptors. GABAA receptors are composed of…”
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The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCS) in the choroid plexus and microvasculature of the brain by Haenggi, T., Soontornmalai, A., Schaub, M.C., Fritschy, J.-M.

“…In the brain, utrophin is present in the choroid plexus epithelium and vascular endothelial cells, whereas the short C-terminal isoform of dystrophin (Dp71) is…”
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Specific GABAA circuits in brain development and therapy by MÖHLER, H, FRITSCHY, J.-M, CRESTANI, F, HENSCH, T, RUDOLPH, U

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Specific GABA A circuits in brain development and therapy by Möhler, H., Fritschy, J.-M., Crestani, F., Hensch, T., Rudolph, U.

“…GABAergic interneurons are highly diverse and operate with a corresponding diversity of GABA A receptor subtypes in controlling behaviour. In this article, we…”
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NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins by Wenzel, Andreas, Fritschy, Jean Marc, Mohler, Hanns, Benke, Dietmar

“…: Changes in the expression of the NMDA receptor subunits (NRs) NR2A, 2B, and 2C were investigated in histo blots of the developing rat brain with…”
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GABAergic phenotype of periglomerular cells in the rodent olfactory bulb by Panzanelli, P., Fritschy, J.M., Yanagawa, Y., Obata, K., Sassoè-Pognetto, M.

“…Periglomerular (PG) cells in the rodent olfactory bulb are heterogeneous anatomically and neurochemically. Here we investigated whether major classes of PG…”
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Differential Synaptic Localization of Two Major $\gamma $-aminobutyric Acid Type A Receptor $\alpha $ Subunits on Hippocampal Pyramidal Cells by Nusser, Zoltan, Sieghart, Werner, Benke, Dietmar, Fritschy, Jean-Marc, Somogyi, Peter

“…Hippocampal pyramidal cells, receiving domain specific GABAergic inputs, express up to 10 different subunits of the $\gamma $-aminobutyric acid type A…”
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