Search Results - "Fritsche, G"

A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank by Bi, Wenjian, Fritsche, Lars G., Mukherjee, Bhramar, Kim, Sehee, Lee, Seunggeun

“…With increasing biobanking efforts connecting electronic health records and national registries to germline genetics, the time-to-event data analysis has…”
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Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study by Budu-Aggrey, Ashley, Brumpton, Ben, Tyrrell, Jess, Watkins, Sarah, Modalsli, Ellen H, Celis-Morales, Carlos, Ferguson, Lyn D, Vie, Gunnhild Åberge, Palmer, Tom, Fritsche, Lars G, Løset, Mari, Nielsen, Jonas Bille, Zhou, Wei, Tsoi, Lam C, Wood, Andrew R, Jones, Samuel E, Beaumont, Robin, Saunes, Marit, Romundstad, Pål Richard, Siebert, Stefan, McInnes, Iain B, Elder, James T, Davey Smith, George, Frayling, Timothy M, Åsvold, Bjørn Olav, Brown, Sara J, Sattar, Naveed, Paternoster, Lavinia

“…Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship…”
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Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies by Zhou, Wei, Nielsen, Jonas B., Fritsche, Lars G., Dey, Rounak, Gabrielsen, Maiken E., Wolford, Brooke N., LeFaive, Jonathon, VandeHaar, Peter, Gagliano, Sarah A., Gifford, Aliya, Bastarache, Lisa A., Wei, Wei-Qi, Denny, Joshua C., Lin, Maoxuan, Hveem, Kristian, Kang, Hyun Min, Abecasis, Goncalo R., Willer, Cristen J., Lee, Seunggeun

“…In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls. Both…”
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On cross-ancestry cancer polygenic risk scores by Fritsche, Lars G, Ma, Ying, Zhang, Daiwei, Salvatore, Maxwell, Lee, Seunggeun, Zhou, Xiang, Mukherjee, Bhramar

“…Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with…”
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Exploring and visualizing large-scale genetic associations by using PheWeb by Gagliano Taliun, Sarah A., VandeHaar, Peter, Boughton, Andrew P., Welch, Ryan P., Taliun, Daniel, Schmidt, Ellen M., Zhou, Wei, Nielsen, Jonas B., Willer, Cristen J., Lee, Seunggeun, Fritsche, Lars G., Boehnke, Michael, Abecasis, Gonçalo R.

“…The ability of investigators to explore their own data by alternating between these two view types, is an increasingly common feature of large-scale…”
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Age-Related Macular Degeneration: Genetics and Biology Coming Together by Fritsche, Lars G, Fariss, Robert N, Stambolian, Dwight, Abecasis, Gonçalo R, Curcio, Christine A, Swaroop, Anand

“…Genetic and genomic studies have enhanced our understanding of complex neurodegenerative diseases that exert a devastating impact on individuals and society…”
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Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative by Fritsche, Lars G., Gruber, Stephen B., Wu, Zhenke, Schmidt, Ellen M., Zawistowski, Matthew, Moser, Stephanie E., Blanc, Victoria M., Brummett, Chad M., Kheterpal, Sachin, Abecasis, Gonçalo R., Mukherjee, Bhramar

“…Health systems are stewards of patient electronic health record (EHR) data with extraordinarily rich depth and breadth, reflecting thousands of diagnoses and…”
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Interaction analysis under misspecification of main effects: Some common mistakes and simple solutions by Zhang, Min, Yu, Youfei, Wang, Shikun, Salvatore, Maxwell, G. Fritsche, Lars, He, Zihuai, Mukherjee, Bhramar

“…The statistical practice of modeling interaction with two linear main effects and a product term is ubiquitous in the statistical and epidemiological…”
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The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities by Beesley, Lauren J., Salvatore, Maxwell, Fritsche, Lars G., Pandit, Anita, Rao, Arvind, Brummett, Chad, Willer, Cristen J., Lisabeth, Lynda D., Mukherjee, Bhramar

“…Biobanks linked to electronic health records provide rich resources for health‐related research. With improvements in administrative and informatics…”
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Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction by Zhuang, Yongwen, Kim, Na Yeon, Fritsche, Lars G, Mukherjee, Bhramar, Lee, Seunggeun

“…Genetic variants can contribute differently to trait heritability by their functional categories, and recent studies have shown that incorporating functional…”
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Assessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis by Clark-Boucher, Dylan, Boss, Jonathan, Salvatore, Maxwell, Smith, Jennifer A, Fritsche, Lars G, Mukherjee, Bhramar

“…Since the beginning of the Coronavirus Disease 2019 (COVID-19) pandemic, a focus of research has been to identify risk factors associated with COVID-19-related…”
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Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks by Fritsche, Lars G, Nam, Kisung, Du, Jiacong, Kundu, Ritoban, Salvatore, Maxwell, Shi, Xu, Lee, Seunggeun, Burgess, Stephen, Mukherjee, Bhramar

“…To overcome the limitations associated with the collection and curation of COVID-19 outcome data in biobanks, this study proposes the use of polygenic risk…”
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Systemic complement activation in age-related macular degeneration by Scholl, Hendrik P N, Charbel Issa, Peter, Walier, Maja, Janzer, Stefanie, Pollok-Kopp, Beatrix, Börncke, Florian, Fritsche, Lars G, Chong, Ngaihang V, Fimmers, Rolf, Wienker, Thomas, Holz, Frank G, Weber, Bernhard H F, Oppermann, Martin

“…Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the…”
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Genome-wide analysis of disease progression in age-related macular degeneration by Yan, Qi, Ding, Ying, Liu, Yi, Sun, Tao, Fritsche, Lars G, Clemons, Traci, Ratnapriya, Rinki, Klein, Michael L, Cook, Richard J, Liu, Yu, Fan, Ruzong, Wei, Lai, Abecasis, Gonçalo R, Swaroop, Anand, Chew, Emily Y, Weeks, Daniel E, Chen, Wei

“…Abstract Family- and population-based genetic studies have successfully identified multiple disease-susceptibility loci for Age-related macular degeneration…”
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Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk by Rivera, Andrea, Fisher, Sheila A., Fritsche, Lars G., Keilhauer, Claudia N., Lichtner, Peter, Meitinger, Thomas, Weber, Bernhard H.F.

“…Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include…”
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Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis by Graham, Sarah E., Nielsen, Jonas B., Zawistowski, Matthew, Zhou, Wei, Fritsche, Lars G., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Surakka, Ida, Hornsby, Whitney E., Fermin, Damian, Larach, Daniel B., Kheterpal, Sachin, Brummett, Chad M., Lee, Seunggeun, Kang, Hyun Min, Abecasis, Goncalo R., Romundstad, Solfrid, Hallan, Stein, Sampson, Matthew G., Hveem, Kristian, Willer, Cristen J.

“…Chronic kidney disease (CKD) is a growing health burden currently affecting 10–15% of adults worldwide. Estimated glomerular filtration rate (eGFR) as a marker…”
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CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors by Corbo, Joseph C, Lawrence, Karen A, Karlstetter, Marcus, Myers, Connie A, Abdelaziz, Musa, Dirkes, William, Weigelt, Karin, Seifert, Martin, Benes, Vladimir, Fritsche, Lars G, Weber, Bernhard H F, Langmann, Thomas

“…Approximately 98% of mammalian DNA is noncoding, yet we understand relatively little about the function of this enigmatic portion of the genome. The…”
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An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD) by Fritsche, Lars G., Lauer, Nadine, Hartmann, Andrea, Stippa, Selina, Keilhauer, Claudia N., Oppermann, Martin, Pandey, Manoj K., Köhl, Jörg, Zipfel, Peter F., Weber, Bernhard H.F., Skerka, Christine

“…A frequent deletion of complement factor H (CFH)-related genes CFHR3 and CFHR1 (ΔCFHR3/CFHR1) is considered to have a protective effect against age-related…”
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Assessment of a causal relationship between body mass index and atopic dermatitis by Budu-Aggrey, Ashley, Watkins, Sarah H., Brumpton, Ben, Løset, Mari, Tyrrell, Jess, Modalsli, Ellen H., Vie, Gunnhild Åberge, Palmer, Tom, Fritsche, Lars G., Nielsen, Jonas Bille, Romundstad, Pål Richard, Davey Smith, George, Åsvold, Bjørn Olav, Paternoster, Lavinia, Brown, Sara J.

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Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes by Salerno, S., Zhao, Z., Prabhu Sankar, S., Salvatore, M., Gu, T., Fritsche, L. G., Lee, S., Lisabeth, L. D., Valley, T. S., Mukherjee, B.

“…Background Whilst the COVID‐19 diagnostic test has a high false‐negative rate, not everyone initially negative is re‐tested. Michigan Medicine, a primary…”
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