Search Results - "Frith, Jessica E"

Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect by Kusuma, Gina D, Carthew, James, Lim, Rebecca, Frith, Jessica E

“…Cues from the extracellular environment, including physical stimuli, are well known to affect mesenchymal stem cell (MSC) properties in terms of proliferation…”
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The influence of substrate creep on mesenchymal stem cell behaviour and phenotype by Cameron, Andrew. R, Frith, Jessica. E, Cooper-White, Justin. J

“…Abstract Human mesenchymal stem cells (hMSCs) are capable of probing and responding to the mechanical properties of their substrate. Although most biological…”
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Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy by Wilson, Alison, Hodgson-Garms, Margeaux, Frith, Jessica E, Genever, Paul

“…Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising…”
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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling by Frith, Jessica E., Kusuma, Gina D., Carthew, James, Li, Fanyi, Cloonan, Nicole, Gomez, Guillermo A., Cooper-White, Justin J.

“…Mechanotransduction is a strong driver of mesenchymal stem cell (MSC) fate. In vitro, variations in matrix mechanics invoke changes in MSC proliferation,…”
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To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles by Kusuma, Gina D, Barabadi, Mehri, Tan, Jean L, Morton, David A V, Frith, Jessica E, Lim, Rebecca

“…Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by stem cells exert similar therapeutic effects and these have been…”
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Five Piconewtons: The Difference between Osteogenic and Adipogenic Fate Choice in Human Mesenchymal Stem Cells by Han, Pingping, Frith, Jessica E, Gomez, Guillermo A, Yap, Alpha S, O’Neill, Geraldine M, Cooper-White, Justin J

“…The ability of mesenchymal stem cells to sense nanoscale variations in extracellular matrix (ECM) compositions in their local microenvironment is crucial to…”
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The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells by Cameron, Andrew R, Frith, Jessica E, Gomez, Guillermo A, Yap, Alpha S, Cooper-White, Justin J

“…Abstract Cell behaviours within tissues are influenced by a broad array of physical and biochemical microenvironmental factors. Whilst ‘stiffness’ is a…”
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Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential by Frith, Jessica E, Thomson, Brian, Genever, Paul G

“…Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation along the osteogenic, chondrogenic, and adipogenic lineages and have potential…”
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Mechanical Properties and In Vitro Behavior of Additively Manufactured and Functionally Graded Ti6Al4V Porous Scaffolds by Onal, Ezgi, Frith, Jessica E, Marten Jurg, Wu, Xinhua, Molotnikov, Andrey

“…Functionally graded lattice structures produced by additive manufacturing are promising for bone tissue engineering. Spatial variations in their porosity are…”
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Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems by Devendran, Citsabehsan, Carthew, James, Frith, Jessica E., Neild, Adrian

“…Acoustic fields are capable of manipulating biological samples contained within the enclosed and highly controlled environment of a microfluidic chip in a…”
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Induced pluripotent stem cell-derived mesenchymal stem cells reverse bleomycin-induced pulmonary fibrosis and related lung stiffness by Chakraborty, Amlan, Wang, Chao, Hodgson-Garms, Margeaux, Broughton, Brad R.S., Frith, Jessica E., Kelly, Kilian, Samuel, Chrishan S.

“…Idiopathic pulmonary fibrosis (IPF) is characterised by lung scarring and stiffening, for which there is no effective cure. Based on the immunomodulatory and…”
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Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture by Carthew, James, Abdelmaksoud, Hazem H., Hodgson‐Garms, Margeaux, Aslanoglou, Stella, Ghavamian, Sara, Elnathan, Roey, Spatz, Joachim P., Brugger, Juergen, Thissen, Helmut, Voelcker, Nicolas H., Cadarso, Victor J., Frith, Jessica E.

“…Cells are able to perceive complex mechanical cues from their microenvironment, which in turn influences their development. Although the understanding of these…”
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Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies by Kusuma, Gina D, Li, Anqi, Zhu, Dandan, McDonald, Hannah, Inocencio, Ishmael M, Chambers, Daniel C, Sinclair, Kenneth, Fang, Haoyun, Greening, David W, Frith, Jessica E, Lim, Rebecca

“…Therapeutic benefits of mesenchymal stem cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines,…”
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A systematic investigation of the effects of TGF-β3 and mechanical stimulation on tenogenic differentiation of mesenchymal stromal cells in a poly(ethylene glycol)/gelatin-based hydrogel by Donderwinkel, Ilze, Tuan, Rocky S., Cameron, Neil R., Frith, Jessica E.

“…High post-surgical failure rates following tendon injury generate high medical costs and poor patient recovery. Cell-based tendon tissue engineering has the…”
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Editorial: Stem Cells as Targeted Drug Delivery Vehicles by Kusuma, Gina D, Frith, Jessica E, Sobey, Christopher G, Lim, Rebecca

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Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments by Huynh, Gabriel T, Kesarwani, Vidhishri, Walker, Julia A, Frith, Jessica E, Meagher, Laurence, Corrie, Simon R

“…Reactive oxygen species (ROS) and dissolved oxygen play key roles across many biological processes, and fluorescent stains and dyes are the primary tools used…”
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Microbioreactor array screening of Wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells by Frith, Jessica E, Titmarsh, Drew M, Padmanabhan, Harish, Cooper-White, Justin J

“…Cellular microenvironmental conditions coordinate to regulate stem cell populations and their differentiation. Mesenchymal precursor cells (MPCs), which have…”
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Microfluidic Encapsulation of Human Mesenchymal Stem Cells for Articular Cartilage Tissue Regeneration by Li, Fanyi, Truong, Vinh X, Thissen, Helmut, Frith, Jessica E, Forsythe, John S

“…Stem cell injections for the treatment of articular cartilage damage are a promising approach to achieve tissue regeneration. However, this method is…”
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Defined high protein content surfaces for stem cell culture by Doran, Michael R, Frith, Jessica E, Prowse, Andrew B.J, Fitzpatrick, Jane, Wolvetang, Ernst J, Munro, Trent P, Gray, Peter P, Cooper-White, Justin J

“…Abstract Unlocking the clinical potential of stem cell based therapies requires firstly elucidation of the biological mechanisms which direct stem cell fate…”
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Tendon tissue engineering: Current progress towards an optimized tenogenic differentiation protocol for human stem cells by Donderwinkel, Ilze, Tuan, Rocky S., Cameron, Neil R., Frith, Jessica E.

“…Tendons are integral to our daily lives by allowing movement and locomotion but are frequently injured, leading to patient discomfort and impaired mobility…”
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