Search Results - "Frison, Michele"

Mitochondrial Mechanisms of Sporadic Parkinsonism: Role of the 18 KDA Protein TSPO by Frison, Michele

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Breast cancer cells exploit mitophagy to exert therapy resistance by Hardy, Liana, Frison, Michele, Campanella, Michelangelo

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Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy by Georgakopoulos, Nikolaos D., Frison, Michele, Alvarez, Maria Soledad, Bertrand, Hélène, Wells, Geoff, Campanella, Michelangelo

“…Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular…”
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Neurodegenerative Loss of Mitochondrial Quality via the 18kDa Protein TSPO by Frison, Michele, Desai, Radha, Singh, Aarti, Hardy, Liana, Campanella, Michelangelo

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A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling by Gatliff, Jemma, East, Daniel A, Singh, Aarti, Alvarez, Maria Soledad, Frison, Michele, Matic, Ivana, Ferraina, Caterina, Sampson, Natalie, Turkheimer, Federico, Campanella, Michelangelo

“…The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is…”
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Controlled and Impaired Mitochondrial Quality in Neurons: Molecular Physiology and Prospective Pharmacology by Matic, Ivana, Strobbe, Daniela, Frison, Michele, Campanella, Michelangelo

“…Neurodegenerative conditions are heavily influenced by the quality of mitochondrial function thus focusing the general attention on their physiopathology. The…”
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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels by Tábara, Luis Carlos, Burr, Stephen P, Frison, Michele, Chowdhury, Suvagata R, Paupe, Vincent, Nie, Yu, Johnson, Mark, Villar-Azpillaga, Jara, Viegas, Filipa, Segawa, Mayuko, Anand, Hanish, Petkevicius, Kasparas, Chinnery, Patrick F, Prudent, Julien

“…Mitochondrial dynamics play a critical role in cell fate decisions and in controlling mtDNA levels and distribution. However, the molecular mechanisms linking…”
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Cell lineage-specific mitochondrial resilience during mammalian organogenesis by Burr, Stephen P., Klimm, Florian, Glynos, Angelos, Prater, Malwina, Sendon, Pamella, Nash, Pavel, Powell, Christopher A., Simard, Marie-Lune, Bonekamp, Nina A., Charl, Julia, Diaz, Hector, Bozhilova, Lyuba V., Nie, Yu, Zhang, Haixin, Frison, Michele, Falkenberg, Maria, Jones, Nick, Minczuk, Michal, Stewart, James B., Chinnery, Patrick F.

“…Mitochondrial activity differs markedly between organs, but it is not known how and when this arises. Here we show that cell lineage-specific expression…”
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The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity by Frison, Michele, Faccenda, Danilo, Abeti, Rosella, Rigon, Manuel, Strobbe, Daniela, England-Rendon, Britannie S., Cash, Diana, Barnes, Katy, Sadeghian, Mona, Sajic, Marija, Wells, Lisa A., Xia, Dong, Giunti, Paola, Smith, Kenneth, Mortiboys, Heather, Turkheimer, Federico E., Campanella, Michelangelo

“…Dysfunctional mitochondria characterise Parkinson’s Disease (PD). Uncovering etiological molecules, which harm the homeostasis of mitochondria in response to…”
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High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life by Glynos, Angelos, Bozhilova, Lyuba V, Frison, Michele, Burr, Stephen, Stewart, James B, Chinnery, Patrick F

“…Heteroplasmic mitochondrial DNA (mtDNA) mutations are a major cause of inherited disease and contribute to common late-onset human disorders. The late onset…”
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Novel defect in phosphatidylinositol 4‐kinase type 2‐alpha (PI4K2A) at the membrane‐enzyme interface is associated with metabolic cutis laxa by Mohamed, Miski, Gardeitchik, Thatjana, Balasubramaniam, Shanti, Guerrero‐Castillo, Sergio, Dalloyaux, Daisy, Kraaij, Sanne, Venselaar, Hanka, Hoischen, Alexander, Urban, Zsolt, Brandt, Ulrich, Al‐Shawi, Raya, Simons, J. Paul, Frison, Michele, Ngu, Lock‐Hock, Callewaert, Bert, Spelbrink, Hans, Kallemeijn, Wouter W., Aerts, Johannes M. F. G., Waugh, Mark G., Morava, Eva, Wevers, Ron A.

“…Inherited cutis laxa, or inelastic, sagging skin is a genetic condition of premature and generalised connective tissue ageing, affecting various elastic…”
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TSPO drives post-translational modifications of the VDAC regulating mitochondrial signaling and quality control mechanisms by Gatliff, Jemma, East, Daniel, Singh, Aarti, Alvarez, Maria Soledad, Frison, Michele, Matic, Ivana, Ferraina, Caterina, Sampson, Natalie, Turkheimer, Federico, Campanella, Michelangelo

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A role for TSPO in mitochondrial Ca 2+ homeostasis and redox stress signaling by Gatliff, Jemma, East, Daniel A, Singh, Aarti, Alvarez, Maria Soledad, Frison, Michele, Matic, Ivana, Ferraina, Caterina, Sampson, Natalie, Turkheimer, Federico, Campanella, Michelangelo

“…The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is…”
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