Search Results - "Friesen, Rick"

Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase by Asante-Appiah, Ernest, Patel, Sangita, Desponts, Caroline, Taylor, Jillian M., Lau, Cheuk, Dufresne, Claude, Therien, Michel, Friesen, Rick, Becker, Joseph W., Leblanc, Yves, Kennedy, Brian P., Scapin, Giovanna

“…PTP-1B represents an attractive target for the treatment of type 2 diabetes and obesity. Given the role that protein phosphatases play in the regulation of…”
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Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain by Colucci, John, Boyd, Michael, Berthelette, Carl, Chiasson, Jean-Francois, Wang, Zhaoyin, Ducharme, Yves, Friesen, Rick, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex G., Clarke, Patsy, Rowland, Steve, Xu, Daigen, Han, Yongxin

“…The discovery of a highly potent and selective EP4 antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and…”
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The YRD Motif Is a Major Determinant of Substrate and Inhibitor Specificity in T-cell Protein-tyrosine Phosphatase by Asante-Appiah, Ernest, Ball, Kristen, Bateman, Kevin, Skorey, Kathryn, Friesen, Rick, Desponts, Caroline, Payette, Paul, Bayly, Christopher, Zamboni, Robert, Scapin, Giovanna, Ramachandran, Chidambaram, Kennedy, Brian P.

“…We have studied T-cell protein-tyrosine phosphatase (TCPTP) as a model phosphatase in an attempt to unravel amino acid residues that may influence the design…”
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The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E 2 Subtype 4 Receptor Antagonist by Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Lévesque, Jean-François, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O’Neill, Gary, Ducharme, Yves, Friesen, Rick

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The Discovery of 4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic Acid (MK-2894), A Potent and Selective Prostaglandin E2 Subtype 4 Receptor Antagonist by Blouin, Marc, Han, Yongxin, Burch, Jason, Farand, Julie, Mellon, Christophe, Gaudreault, Mireille, Wrona, Mark, Lévesque, Jean-François, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Vigneault, Erika, Therien, Alex, Clark, Patsy, Rowland, Steve, Xu, Daigen, O’Neill, Gary, Ducharme, Yves, Friesen, Rick

“…The discovery of highly potent and selective second generation EP4 antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic…”
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Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists by Liu, Shilan, Liu, Yinhui, Wang, Hongmei, Ding, YiLi, Wu, Hao, Dong, Jingchao, Wong, Angela, Chen, Shu-Hui, Li, Ge, Chan, Manuel, Sawyer, Nicole, Gervais, Francois G., Henault, Martin, Kargman, Stacia, Bedard, Leanne L., Han, Yongxin, Friesen, Rick, Lobell, Robert B., Stout, David M.

“…A novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists were identified. We describe…”
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Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain by Colucci, John, Boyd, Michael, Berthelette, Carl, Chiasson, Jean-Francois, Wang, Zhaoyin, Ducharme, Yves, Friesen, Rick, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex G, Clarke, Patsy, Rowland, Steve, Xu, Daigen, Han, Yongxin

“…The discovery of a highly potent and selective EP(4) antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and…”
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