Search Results - "Friesen, Claudia"

Cell death sensitization of leukemia cells by opioid receptor activation by Friesen, Claudia, Roscher, Mareike, Hormann, Inis, Fichtner, Iduna, Alt, Andreas, Hilger, Ralf A, Debatin, Klaus-Michael, Miltner, Erich

“…Cyclic AMP (cAMP) regulates a number of cellular processes and modulates cell death induction. cAMP levels are altered upon stimulation of specific…”
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Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells by Friesen, Claudia, Herr, Ingrid, Krammer, Peter H, Debatin, Klaus-Michael

“…Cytotoxic drugs used in chemotherapy of leukemias and solid tumors cause apoptosis in target cells. In lymphoid cells the CD95 (APO-1/Fas)/CD95 ligand (CD95-L)…”
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Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis by FULDA, Simone, MEYER, Eric, FRIESEN, Claudia, SUSIN, Santos A, KROEMER, Guido, DEBATIN, Klaus-Michael

“…Apoptosis in response to cellular stress such as treatment with cytotoxic drugs is mediated by effector caspases (caspase-3) which can be activated by…”
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DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin by Friesen, Claudia, Uhl, Miriam, Pannicke, Ulrich, Schwarz, Klaus, Miltner, Erich, Debatin, Klaus-Michael

“…Resistance toward cytotoxic drugs is one of the primary causes for therapeutic failure in cancer therapy. DNA repair mechanisms as well as deficient caspases…”
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Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases) by LOS, M, HERR, I, FRIESEN, C, FULDA, S, SCHULZE-OSTHOFF, K, DEBATIN, K.-M

“…The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. We report here that tumor cells resistant to CD95 (APO-1/Fas)…”
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Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma by Onken, Julia, Friesen, Claudia, Vajkoczy, Peter, Misch, Martin

“…D,L-Methadone increases sensitivity toward chemotherapy of different tumor cell populations. We evaluated the safety and tolerance of additional use of…”
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Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma by Friesen, Claudia, Hormann, Inis, Roscher, Mareike, Fichtner, Iduna, Alt, Andreas, Hilger, Ralf, Debatin, Klaus-Michael, Miltner, Erich

“…Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and…”
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Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance by Friesen, Claudia, Roscher, Mareike, Alt, Andreas, Miltner, Erich

“…The therapeutic opioid drug methadone (d,l-methadone hydrochloride) is the most commonly used maintenance medication for outpatient treatment of opioid…”
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Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio- and chemoresistance by inhibition of the anti-apoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large by Friesen, Claudia, Roscher, Mareike, Hormann, Inis, Leib, Oliver, Marx, Sebastian, Moreno, Josue, Miltner, Erich

“…Abstract Aim The emerging interest in radioimmunotherapies employing alpha-emitters for cancer treatment like high risk-leukaemia leads to the question of how…”
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Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2 by Schwarz, Klaus, Pannicke, Ulrich, Hönig, Manfred, Hess, Isabell, Friesen, Claudia, Holzmann, Karlheinz, Rump, Eva-Maria, Barth, Thomas F, Rojewski, Markus T, Schulz, Ansgar, Boehm, Thomas, Friedrich, Wilhelm

“…Human severe combined immunodeficiencies (SCID) are phenotypically and genotypically heterogeneous diseases. Reticular dysgenesis is the most severe form of…”
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Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells by Roscher, Mareike, Hormann, Inis, Leib, Oliver, Marx, Sebastian, Moreno, Josue, Miltner, Erich, Friesen, Claudia

“…Radioimmunotherapy (RIT) is an emerging treatment option for non-Hodgkin lymphoma (NHL) producing higher overall response and complete remission rates compared…”
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Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells by FRIESEN, Claudia, GLATTING, Gerhard, KOOP, Bernd, SCHWARZ, Klaus, MORGENSTERN, Alfred, APOSTOLIDIS, Christos, DEBATIN, Klaus-Michael, RESKE, Sven N

“…Chemoresistance and radioresistance are considered one of the primary reasons for therapeutic failure in leukemias and solid tumors. Targeted radiotherapy…”
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Two CD95 (APO-1/Fas) signaling pathways by Scaffidi, Carsten, Fulda, Simone, Srinivasan, Anu, Friesen, Claudia, Li, Feng, Tomaselli, Kevin J., Debatin, Klaus-Michael, Krammer, Peter H., Peter, Marcus E.

“…We have identified two cell types, each using almost exclusively one of two different CD95 (APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was…”
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The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells by FULDA, S, SIEVERTS, H, FRIESEN, C, HERR, I, DEBATIN, K.-M

“…Anticancer agents have been shown to trigger apoptosis in chemosensitive tumors such as neuroblastomas. We previously identified activation of the CD95 system…”
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Anti-CD45 Monoclonal Antibody YAML568: A Promising Radioimmunoconjugate for Targeted Therapy of Acute Leukemia by Glatting, Gerhard, Muller, Marguerite, Koop, Bernd, Hohl, Kathrin, Friesen, Claudia, Neumaier, Bernd, Berrie, Eleanor, Bird, Pru, Hale, Geoffrey, Blumstein, Norbert M, Waldmann, Herman, Bunjes, Donald, Reske, Sven N

“…The outcome of hematopoietic cell transplantation for hematologic malignancies may be improved by delivering targeted radiation to hematopoietic organs while…”
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Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors by FULDA, S, FRIESEN, C, LOS, M, SCAFFIDI, C, MIER, W, BENEDICT, M, NUNEZ, G, KRAMMER, P. H, PETER, M. E, DEBATIN, K.-M

“…Betulinic acid (BA), a melanoma-specific cytotoxic agent, induced apoptosis in neuroectodermal tumors, such as neuroblastoma, medulloblastoma, and Ewing's…”
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Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy by Stahnke, Karsten, Fulda, Simone, Friesen, Claudia, Strauß, Gudrun, Debatin, Klaus-Michael

“…In addition to myelosuppression, anticancer drugs cause rapid and persistent depletion of lymphocytes, possibly by direct apoptosis induction in mature T and B…”
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Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system by Fulda, Simone, Los, Marek, Friesen, Claudia, Debatin, Klaus‐Michael

“…We have identified the CD95 system as a key mediator of chemotherapy‐induced apoptosis in leukemia and neuroblastoma cells. Here, we report that sensitivity of…”
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Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells by Friesen, Claudia, Lubatschofski, Annelie, Kotzerke, Jörg, Buchmann, Inga, Reske, Sven N, Debatin, Klaus-Michael

“…Beta-irradiation used for systemic radioimmunotherapy (RIT) is a promising treatment approach for high-risk leukaemia and lymphoma. In bone marrow-selective…”
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Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells by Friesen, C, Fulda, S, Debatin, K M

“…Induction of CD95 ligand (CD95-L) may contribute to drug-induced apoptosis in chemosensitive leukemias and solid tumors. Here we report that induction of…”
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