Search Results - "Friese, M. A"

Exceptional Resistance of Human H2 Glioblastoma Cells to Complement-Mediated Killing by Expression and Utilization of Factor H and Factor H-Like Protein 1 by Junnikkala, S, Jokiranta, T. S, Friese, M. A, Jarva, H, Zipfel, P. F, Meri, S

“…Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis…”
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Different regulation of factor H and FHL‐1/reconectin by inflammatory mediators and expression of the two proteins in rheumatoid arthritis (RA) by Friese, M. A., Hellwage, J., Jokiranta, T. S., Meri, S., Müller‐Quernheim, H. J., Peter, H. H., Eibel, H., Zipfel, P. F.

“…Factor H and the FHL‐1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is…”
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Release of endogenous anti‐inflammatory complement regulators FHL‐1 and factor H protects synovial fibroblasts during rheumatoid arthritis by FRIESE, M. A., MANUELIAN, T., JUNNIKKALA, S., HELLWAGE, J., MERI, S., PETER, H. H., GORDON, D. L., EIBEL, H., ZIPFEL, P. F.

“…SUMMARY Rheumatoid arthritis is a chronic inflammatory disease of unknown aetiology predominantly affecting cells and tissues of synovial joints. Here we show…”
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The innate immune response in the central nervous system and its role in glioma immune surveillance by Friese, M A, Steinle, A, Weller, M

“…The innate immune system encompasses natural killer (NK) cells, macrophages and granulocytes, the complement system and antimicrobial peptides. Recognition…”
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Autoimmune synaptic encephalopathies by Friese, M A, Magnus, T

“…Antibody-associated limbic encephalitis was usually seen as a paraneoplastic syndrome where the antibodies would target intracellular proteins. However, recent…”
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Identification of early neurodegenerative pathways in progressive multiple sclerosis by Kaufmann, Max, Schaupp, Anna-Lena, Sun, Rosa, Coscia, Fabian, Dendrou, Calliope A., Cortes, Adrian, Kaur, Gurman, Evans, Hayley G., Mollbrink, Annelie, Navarro, José Fernández, Sonner, Jana K., Mayer, Christina, DeLuca, Gabriele C., Lundeberg, Joakim, Matthews, Paul M., Attfield, Kathrine E., Friese, Manuel A., Mann, Matthias, Fugger, Lars

“…Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration, which causes cumulative disability and is refractory to current…”
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FHL-1/reconectin and factor H: two human complement regulators which are encoded by the same gene are differently expressed and regulated by Friese, Manuel A, Hellwage, Jens, Jokiranta, T.Sakari, Meri, Seppo, Peter, Hans H, Eibel, Hermann, Zipfel, Peter F

“…FHL-1/reconectin and factor H are two human complement regulators which are encoded by a single gene. FHL-1/reconectin contains the first 7 of 20 SCR protein…”
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Factor H and disease: a complement regulator affects vital body functions by Zipfel, Peter F., Hellwage, Jens, Friese, Manuel A., Hegasy, Guido, Jokiranta, Sakari T., Meri, Seppo

“…Factor H is a multidomain and multifunctional protein. As a complement regulator factor H determines the fate of newly formed C3b and controls formation and…”
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The value of animal models for drug development in multiple sclerosis by Friese, Manuel A., Montalban, Xavier, Willcox, Nick, Bell, John I., Martin, Roland, Fugger, Lars

“…The rodent model for multiple sclerosis, experimental allergic (autoimmune) encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the…”
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Plasma pTau‐217 and N‐terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid‐β positive individuals by Woo, Marcel S., Tissot, Cécile, Lantero‐Rodriguez, Juan, Snellman, Anniina, Therriault, Joseph, Rahmouni, Nesrine, Macedo, Arthur C., Servaes, Stijn, Wang, Yi‐Ting, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Triana‐Baltzer, Gallen, Kolb, Hartmuth C., Stevenson, Jenna, Mayer, Christina, Kobayashi, Eliane, Massarweh, Gassan, Friese, Manuel A., Pascoal, Tharick A., Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, Rosa‐Neto, Pedro

“…INTRODUCTION We set out to identify tau PET‐positive (A+T+) individuals among amyloid‐beta (Aβ) positive participants using plasma biomarkers. METHODS In this…”
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14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2 by Woo, M. S., Nilsson, J., Therriault, J., Rahmouni, N., Brinkmalm, A., Lessa Benedet, Andréa, Ashton, Nicholas J., Macedo, A. C., Servaes, S., Wang, Y. T., Tissot, C., Arias, J. F., Hosseini, S. A., Chamoun, M., Lussier, F. Z., Karikari, Thomas, Stevenson, J., Mayer, C., Ferrari-Souza, J. P., Kobayashi, E., Massarweh, G., Friese, M. A., Pascoal, T. A., Gauthier, S., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, P.

“…Introduction Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic…”
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Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life by Schreurs, Renée R.C.E., Baumdick, Martin E., Sagebiel, Adrian F., Kaufmann, Max, Mokry, Michal, Klarenbeek, Paul L., Schaltenberg, Nicola, Steinert, Fenja L., van Rijn, Jorik M., Drewniak, Agata, The, Sarah-May M.L., Bakx, Roel, Derikx, Joep P.M., de Vries, Niek, Corpeleijn, Willemijn E., Pals, Steven T., Gagliani, Nicola, Friese, Manuel A., Middendorp, Sabine, Nieuwenhuis, Edward E.S., Reinshagen, Konrad, Geijtenbeek, Teunis B.H., van Goudoever, Johannes B., Bunders, Madeleine J.

“…Although the fetal immune system is considered tolerogenic, preterm infants can suffer from severe intestinal inflammation, including necrotizing enterocolitis…”
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T cells and microglia as drivers of multiple sclerosis pathology by Friese, Manuel A., Fugger, Lars

“…One of the many open questions in multiple sclerosis research is whether inflammation in the CNS is initiated by an autoimmune attack, triggered by…”
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Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis by Tzartos, John S, Friese, Manuel A, Craner, Matthew J, Palace, Jackie, Newcombe, Jia, Esiri, Margaret M, Fugger, Lars

“…Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH 17),…”
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Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis by Poch, Tobias, Krause, Jenny, Casar, Christian, Liwinski, Timur, Glau, Laura, Kaufmann, Max, Ahrenstorf, Annika E., Hess, Leonard U., Ziegler, Annerose E., Martrus, Glòria, Lunemann, Sebastian, Sebode, Marcial, Li, Jun, Schwinge, Dorothee, Krebs, Christian F., Franke, Andre, Friese, Manuel A., Oldhafer, Karl J., Fischer, Lutz, Altfeld, Marcus, Lohse, Ansgar W., Huber, Samuel, Tolosa, Eva, Gagliani, Nicola, Schramm, Christoph

“…Little is known about the composition of intrahepatic immune cells and their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). Herein,…”
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Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? by Friese, Manuel A., Fugger, Lars

“…Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered to be an autoimmune disease. Traditionally, CD4+ T helper cells…”
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Identification of the factor XII contact activation site enables sensitive coagulation diagnostics by Heestermans, Marco, Naudin, Clément, Mailer, Reiner K., Konrath, Sandra, Klaetschke, Kristin, Jämsä, Anne, Frye, Maike, Deppermann, Carsten, Pula, Giordano, Kuta, Piotr, Friese, Manuel A., Gelderblom, Mathias, Sickmann, Albert, Preston, Roger J. S., Nofer, Jerzy-Roch, Rose-John, Stefan, Butler, Lynn M., Salomon, Ophira, Stavrou, Evi X., Renné, Thomas

“…Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated…”
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Stem cell transplantation for multiple sclerosis. Hamburg experiences and state of international research by Stellmann, J-P, Stürner, K H, Ufer, F, Havemeister, S, Pöttgen, J, Ayuk Ayuketang, F, Kröger, N, Friese, M A, Heesen, C

“…Autologous hematopoietic stem cell transplantation (aHSCT) is still not the standard treatment for highly inflammatory multiple sclerosis (MS). Even though…”
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Autoimmune synaptische Enzephalopathien by Friese, M.A., Magnus, T.

“…Zusammenfassung Antikörpervermittelte (limbische) Enzephalitiden wurden bisher als paraneoplastische Syndrome mit Antikörpern gegen intrazelluläre Antigene…”
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RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo by FRIESE, Manuel A, WISCHHUSEN, Jörg, WICK, Wolfgang, WEILER, Markus, EISELE, Günter, STEINLE, Alexander, WELLER, Michael

“…Transforming growth factor (TGF)-beta is the key molecule implicated in impaired immune function in human patients with malignant gliomas. Here we report that…”
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