Search Results - "Friend, Della"

Structural elucidation of the mesothelin-mucin-16/CA125 interaction by Rupert, Peter B, Buerger, Matthew, Friend, Della J, Strong, Roland K

“…Mesothelin (MSLN) is a cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed in many cancers. Mesothelin has been…”
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Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets by Crook, Zachary R., Sevilla, Gregory P., Friend, Della, Brusniak, Mi-Youn, Bandaranayake, Ashok D., Clarke, Midori, Gewe, Mesfin, Mhyre, Andrew J., Baker, David, Strong, Roland K., Bradley, Philip, Olson, James M.

“…Protein:protein interactions are among the most difficult to treat molecular mechanisms of disease pathology. Cystine-dense peptides have the potential to…”
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Engineering and functionalization of large circular tandem repeat protein nanoparticles by Correnti, Colin E., Hallinan, Jazmine P., Doyle, Lindsey A., Ruff, Raymond O., Jaeger-Ruckstuhl, Carla A., Xu, Yuexin, Shen, Betty W., Qu, Amanda, Polkinghorn, Caley, Friend, Della J., Bandaranayake, Ashok D., Riddell, Stanley R., Kaiser, Brett K., Stoddard, Barry L., Bradley, Philip

“…Protein engineering has enabled the design of molecular scaffolds that display a wide variety of sizes, shapes, symmetries and subunit compositions. Symmetric…”
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Effects of HLA single chain trimer design on peptide presentation and stability by Finton, Kathryn A K, Rupert, Peter B, Friend, Della J, Dinca, Ana, Lovelace, Erica S, Buerger, Matthew, Rusnac, Domnita V, Foote-McNabb, Ulysses, Chour, William, Heath, James R, Campbell, Jean S, Pierce, Robert H, Strong, Roland K

“…MHC class I " " molecules, coupling MHC heavy chain, β -microglobulin, and a specific peptide into a single polypeptide chain, are widely used in research. To…”
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Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager by Crook, Zachary R, Girard, Emily J, Sevilla, Gregory P, Brusniak, Mi-Youn, Rupert, Peter B, Friend, Della J, Gewe, Mesfin M, Clarke, Midori, Lin, Ida, Ruff, Raymond, Pakiam, Fiona, Phi, Tinh-Doan, Bandaranayake, Ashok, Correnti, Colin E, Mhyre, Andrew J, Nairn, Natalie W, Strong, Roland K, Olson, James M

“…Cystine-dense peptides (CDPs) are a miniprotein class that can drug difficult targets with high affinity and low immunogenicity. Tools for their design,…”
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Computational Protein Design Using Flexible Backbone Remodeling and Resurfacing: Case Studies in Structure-Based Antigen Design by Correia, Bruno E., Ban, Yih-En Andrew, Friend, Della J., Ellingson, Katharine, Xu, Hengyu, Boni, Erica, Bradley-Hewitt, Tyler, Bruhn-Johannsen, Jessica F., Stamatatos, Leonidas, Strong, Roland K., Schief, William R.

“…Computational protein design has promise for vaccine design and other applications. We previously transplanted the HIV 4E10 epitope onto non-HIV protein…”
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Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli by Kisiela, Dagmara I, Avagyan, Hovhannes, Friend, Della, Jalan, Aachal, Gupta, Shivani, Interlandi, Gianluca, Liu, Yan, Tchesnokova, Veronika, Rodriguez, Victoria B, Sumida, John P, Strong, Roland K, Wu, Xue-Ru, Thomas, Wendy E, Sokurenko, Evgeni V

“…Attachment proteins from the surface of eukaryotic cells, bacteria and viruses are critical receptors in cell adhesion or signaling and are primary targets for…”
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Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10 by Finton, Kathryn A K, Larimore, Kevin, Larman, H Benjamin, Friend, Della, Correnti, Colin, Rupert, Peter B, Elledge, Stephen J, Greenberg, Philip D, Strong, Roland K

“…The broadly-neutralizing anti-HIV antibody 4E10 recognizes an epitope in the membrane-proximal external region of the HIV envelope protein gp41. Previous…”
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Publisher Correction: Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets by Crook, Zachary R., Sevilla, Gregory P., Friend, Della, Brusniak, Mi-Youn, Bandaranayake, Ashok D., Clarke, Midori, Gewe, Mesfin, Mhyre, Andrew J., Baker, David, Strong, Roland K., Bradley, Philip, Olson, James M.

“…In the original version of this Article the colour key for the amino acid enrichment score was inadvertently omitted from the lower panel of Figure 5b during…”
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Binding Interactions between Soluble HIV Envelope Glycoproteins and Quaternary-Structure-Specific Monoclonal Antibodies PG9 and PG16 by DAVENPORT, Thaddeus M, FRIEND, Della, ELLINGSON, Katharine, HENGYU XU, CALDWELL, Zachary, SELLHORN, George, KRAFT, Zane, STRONG, Roland K, STAMATATOS, Leonidas

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users by Katsamba, Phinikoula S., Navratilova, Iva, Calderon-Cacia, Maria, Fan, Linsey, Thornton, Kevin, Zhu, Mingde, Bos, Tim Vanden, Forte, Carla, Friend, Della, Laird-Offringa, Ite, Tavares, Gisele, Whatley, John, Shi, Ergang, Widom, Angela, Lindquist, Kevin C., Klakamp, Scott, Drake, Andrew, Bohmann, David, Roell, Marina, Rose, Larry, Dorocke, Jill, Roth, Bruce, Luginbühl, Béatrice, Myszka, David G.

“…To explore the reliability of Biacore-based assays, 22 study participants measured the binding of prostate-specific antigen (PSA) to a monoclonal antibody…”
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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces by Hallinan, Jazmine P., Doyle, Lindsey A., Shen, Betty W., Gewe, Mesfin M., Takushi, Brittany, Kennedy, Madison A., Friend, Della, Roberts, James M., Bradley, Philip, Stoddard, Barry L.

“…Circular tandem repeat proteins (‘cTRPs’) are de novo designed protein scaffolds (in this and prior studies, based on antiparallel two-helix bundles) that…”
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Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10 by Finton, Kathryn A K, Friend, Della, Jaffe, James, Gewe, Mesfin, Holmes, Margaret A, Larman, H Benjamin, Stuart, Andrew, Larimore, Kevin, Greenberg, Philip D, Elledge, Stephen J, Stamatatos, Leonidas, Strong, Roland K

“…The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the…”
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The Soluble Form of IL-1 Receptor Accessory Protein Enhances the Ability of Soluble Type II IL-1 Receptor to Inhibit IL-1 Action by Smith, Dirk E., Hanna, Roberta, Della Friend, Moore, Heather, Chen, Hongbo, Farese, Ann M., MacVittie, Thomas J., Virca, G.Duke, Sims, John E.

“…Regulation of the activity of the proinflammatory cytokine IL-1 is complex, involving transcriptional and translational control, precursor processing, a…”
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Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics by Lin, Ida, Rupert, Peter B., Pilat, Kristina, Ruff, Raymond O., Friend, Della J., Chan, Man Kid, Clarke, Midori, Hoffstrom, Benjamin G., Carter, Jane, Meshinchi, Soheil, Bandaranayake, Ashok D., Mehlin, Christopher, Olson, James M., Strong, Roland K., Correnti, Colin E.

“…Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell…”
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Anti-CD28 Antibody-Initiated Cytokine Storm in Canines by Rosinski, Steven L., Storb, Rainer, Strong, Roland K., Sale, George E., Stone, Diane M., Gewe, Mesfin M., Friend, Della J., Abrams, V. Kraig, Randolph-Habecker, Julie, Graves, Scott S.

“…CD28 signal blockade following T cell receptor activation is under intense investigation as a tolerance-inducing therapy for transplantation. Our goal is to…”
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The IL-6 Signal Transducer, gp130: An Oncostatin M Receptor and Affinity Converter for the LIF Receptor by Gearing, David P., Comeau, Michael R., Friend, Della J., Gimpel, Steven D., Thut, Catherine J., McGourty, Jackie, Brasher, Kelle K., King, Julie A., Gillis, Steven, Mosley, Bruce, Ziegler, Steven F., Cosman, David

“…Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities. LIF is structurally and functionally…”
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A TfR-Binding Cystine-Dense Peptide Promotes Blood–Brain Barrier Penetration of Bioactive Molecules by Crook, Zachary R., Girard, Emily, Sevilla, Gregory P., Merrill, Morgan, Friend, Della, Rupert, Peter B., Pakiam, Fiona, Nguyen, Elizabeth, Yin, Chunfeng, Ruff, Raymond O., Hopping, Gene, Strand, Andrew D., Finton, Kathryn A.K., Coxon, Margo, Mhyre, Andrew J., Strong, Roland K., Olson, James M.

“…The impenetrability of the blood–brain barrier (BBB) to most conventional drugs impedes the treatment of central nervous system (CNS) disorders. Interventions…”
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Structure-Function Analysis of FLT3 Ligand-FLT3 Receptor Interactions Using a Rapid Functional Screen by Graddis, T J, Brasel, K, Friend, D, Srinivasan, S, Wee, S, Lyman, S D, March, C J, McGrew, J T

“…FLT3 ligand (FLT3L) stimulates primitive hematopoietic cells by binding to and activating the FLT3 receptor (FLT3R). We carried out a structure-activity study…”
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Abstract 5573: A high-affinity Optide (optimized peptide) inhibitor of the Hippo pathway’s YAP-TEAD interaction by Crook, Zachary R., Bradley, Philip, Sevilla, Gregory, Friend, Della, King, Chris, Mhyre, Andrew, Strong, Roland, Baker, David, Olson, James M.

“…Abstract The HIPPO pathway plays a critical role in contact inhibition, a pathway that is commonly dysregulated in many human cancers (including liver, colon,…”
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