Search Results - "Friemann, Rosmarie"

Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions by Eriksson, Urszula Kosinska, Fischer, Gerhard, Friemann, Rosmarie, Enkavi, Giray, Tajkhorshid, Emad, Neutze, Richard

“…Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the…”
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Transcription factor clusters regulate genes in eukaryotic cells by Wollman, Adam Jm, Shashkova, Sviatlana, Hedlund, Erik G, Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C

“…Transcription is regulated through binding factors to gene promoters to activate or repress expression, however, the mechanisms by which factors find targets…”
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Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism by Horne, Christopher R., Venugopal, Hariprasad, Panjikar, Santosh, Wood, David M., Henrickson, Amy, Brookes, Emre, North, Rachel A., Murphy, James M., Friemann, Rosmarie, Griffin, Michael D. W., Ramm, Georg, Demeler, Borries, Dobson, Renwick C. J.

“…Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a…”
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Inhibitor binding mode and allosteric regulation of Na+-glucose symporters by Bisignano, Paola, Ghezzi, Chiara, Jo, Hyunil, Polizzi, Nicholas F., Althoff, Thorsten, Kalyanaraman, Chakrapani, Friemann, Rosmarie, Jacobson, Matthew P., Wright, Ernest M., Grabe, Michael

“…Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar…”
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Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid by Pippione, Agnese Chiara, Carnovale, Irene Maria, Bonanni, Davide, Sini, Marcella, Goyal, Parveen, Marini, Elisabetta, Pors, Klaus, Adinolfi, Salvatore, Zonari, Daniele, Festuccia, Claudio, Wahlgren, Weixiao Yuan, Friemann, Rosmarie, Bagnati, Renzo, Boschi, Donatella, Oliaro-Bosso, Simonetta, Lolli, Marco Lucio

“…The aldo-keto reductase 1C3 (AKR1C3) isoform plays a vital role in the biosynthesis of androgens and is considered an attractive target in prostate cancer…”
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Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site by Wahlgren, Weixiao Y., Dunevall, Elin, North, Rachel A., Paz, Aviv, Scalise, Mariafrancesca, Bisignano, Paola, Bengtsson-Palme, Johan, Goyal, Parveen, Claesson, Elin, Caing-Carlsson, Rhawnie, Andersson, Rebecka, Beis, Konstantinos, Nilsson, Ulf J., Farewell, Anne, Pochini, Lorena, Indiveri, Cesare, Grabe, Michael, Dobson, Renwick C. J., Abramson, Jeff, Ramaswamy, S., Friemann, Rosmarie

“…Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise…”
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Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter by Davies, James S., Currie, Michael J., North, Rachel A., Scalise, Mariafrancesca, Wright, Joshua D., Copping, Jack M., Remus, Daniela M., Gulati, Ashutosh, Morado, Dustin R., Jamieson, Sam A., Newton-Vesty, Michael C., Abeysekera, Gayan S., Ramaswamy, Subramanian, Friemann, Rosmarie, Wakatsuki, Soichi, Allison, Jane R., Indiveri, Cesare, Drew, David, Mace, Peter D., Dobson, Renwick C. J.

“…In bacteria and archaea, tripartite ATP-independent periplasmic (TRAP) transporters uptake essential nutrients. TRAP transporters receive their substrates via…”
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Correction: Transcription factor clusters regulate genes in eukaryotic cells by Wollman, Adam Jm, Shashkova, Sviatlana, Hedlund, Erik G, Friemann, Rosmarie, Hohmann, Stefan, Leake, Mark C

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Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 by Lolli, Marco L, Carnovale, Irene M, Pippione, Agnese C, Wahlgren, Weixiao Y, Bonanni, Davide, Marini, Elisabetta, Zonari, Daniele, Gallicchio, Margherita, Boscaro, Valentina, Goyal, Parveen, Friemann, Rosmarie, Rolando, Barbara, Bagnati, Renzo, Adinolfi, Salvatore, Oliaro-Bosso, Simonetta, Boschi, Donatella

“…Aldo-keto reductase 1C3 (AKR1C3) is an attractive target in drug design for its role in resistance to anticancer therapy. Several nonsteroidal…”
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Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase by SHAODONG DAI, FRIEMANN, Rosmarie, GLAUSER, Dominique A, BOURQUIN, Florence, MANIERI, Wanda, SCHÜRMANN, Peter, EKLUND, Hans

“…Oxygen-evolving photosynthetic organisms regulate carbon metabolism through a light-dependent redox signalling pathway. Electrons are shuttled from photosystem…”
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Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter by Currie, Michael J, Davies, James S, Scalise, Mariafrancesca, Gulati, Ashutosh, Wright, Joshua D, Newton-Vesty, Michael C, Abeysekera, Gayan S, Subramanian, Ramaswamy, Wahlgren, Weixiao Y, Friemann, Rosmarie, Allison, Jane R, Mace, Peter D, Griffin, Michael D W, Demeler, Borries, Wakatsuki, Soichi, Drew, David, Indiveri, Cesare, Dobson, Renwick C J, North, Rachel A

“…Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active transporters that receive their substrates via a soluble-binding protein to…”
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Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system by Friemann, Rosmarie, Lee, Kyoung, Brown, Eric N., Gibson, David T., Eklund, Hans, Ramaswamy, S.

“…Bacterial Rieske non‐heme iron oxygenases catalyze the initial hydroxylation of aromatic hydrocarbon substrates. The structures of all three components of one…”
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The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity by North, Rachel A, Wahlgren, Weixiao Y, Remus, Daniela M, Scalise, Mariafrancesca, Kessans, Sarah A, Dunevall, Elin, Claesson, Elin, Soares da Costa, Tatiana P, Perugini, Matthew A, Ramaswamy, S, Allison, Jane R, Indiveri, Cesare, Friemann, Rosmarie, Dobson, Renwick C J

“…Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can…”
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Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125 by Uchtenhagen, Hannes, Friemann, Rosmarie, Raszewski, Grzegorz, Spetz, Anna-Lena, Nilsson, Lennart, Achour, Adnane

“…7C8 is a mouse monoclonal antibody specific for the third hypervariable region (V3) of the human immunodeficiency virus type 2 (HIV-2)-associated protein…”
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Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site by Talavera, Ariel, Mackenzie, Jenny, Garrido, Greta, Friemann, Rosmarie, López-Requena, Alejandro, Moreno, Ernesto, Krengel, Ute

“…► The crystal structure of the 7A7 Fab was solved at high resolution (1.4 Å). ► 7A7 was raised against the murine EGFR, but cross-reacts with the human…”
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Targeting Myeloid Differentiation Using Potent 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors by Sainas, Stefano, Pippione, Agnese C, Lupino, Elisa, Giorgis, Marta, Circosta, Paola, Gaidano, Valentina, Goyal, Parveen, Bonanni, Davide, Rolando, Barbara, Cignetti, Alessandro, Ducime, Alex, Andersson, Mikael, Järvå, Michael, Friemann, Rosmarie, Piccinini, Marco, Ramondetti, Cristina, Buccinnà, Barbara, Al-Karadaghi, Salam, Boschi, Donatella, Saglio, Giuseppe, Lolli, Marco L

“…Human dihydroorotate dehydrogenase (hDHODH) catalyzes the rate-limiting step in de novo pyrimidine biosynthesis, the conversion of dihydroorotate to orotate…”
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On the function of TRAP substrate-binding proteins: Conformational variation of the sialic acid binding protein SiaP by King-Hudson, Te-Rina J., Davies, James S., Quan, Senwei, Currie, Michael J., Tillett, Zachary D., Copping, Jack, Panjikar, Santosh, Friemann, Rosmarie, Allison, Jane R., North, Rachel A., Dobson, Renwick C.J.

“…Tripartite ATP-independent periplasmic (TRAP) transporters are analogous to ABC transporters in that they use a substrate-binding protein to scavenge…”
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Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds by Sainas, Stefano, Pippione, Agnese C., Giorgis, Marta, Lupino, Elisa, Goyal, Parveen, Ramondetti, Cristina, Buccinnà, Barbara, Piccinini, Marco, Braga, Rodolpho C., Andrade, Carolina H., Andersson, Mikael, Moritzer, Ann-Christin, Friemann, Rosmarie, Mensa, Stefano, Al-Karadaghi, Salam, Boschi, Donatella, Lolli, Marco L.

“…A new generation of potent hDHODH inhibitors designed by a scaffold-hopping replacement of the quinolinecarboxylate moiety of brequinar, one of the most potent…”
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Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies by Pippione, Agnese C., Sainas, Stefano, Goyal, Parveen, Fritzson, Ingela, Cassiano, Gustavo C., Giraudo, Alessandro, Giorgis, Marta, Tavella, Tatyana A., Bagnati, Renzo, Rolando, Barbara, Caing-Carlsson, Rhawnie, Costa, Fabio T.M., Andrade, Carolina Horta, Al-Karadaghi, Salam, Boschi, Donatella, Friemann, Rosmarie, Lolli, Marco L.

“…Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine…”
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Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation by TALAVERA, Ariel, FRIEMANN, Rosmarie, KRENGEL, Ute, MORENO, Ernesto, GOMEZ-PUERTA, Silvia, MARTINEZ- FLEITES, Carlos, GARRIDO, Greta, RABASA, Ailem, LOPEZ-REQUENA, Alejandro, PUPO, Amaury, JOHANSEN, Rune F, SANCHEZ, Oliberto

“…Overexpression of the epidermal growth factor (EGF) receptor (EGFR) in cancer cells correlates with tumor malignancy and poor prognosis for cancer patients…”
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