Search Results - "Frieman, Matthew"

Selective Naked-Eye Detection of SARS-CoV‑2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles by Moitra, Parikshit, Alafeef, Maha, Dighe, Ketan, Frieman, Matthew B, Pan, Dipanjan

“…The current outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its…”
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The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis by Venkataraman, Thiagarajan, Frieman, Matthew B.

“…Many survivors of the 2003 outbreak of severe acute respiratory syndrome (SARS) developed residual pulmonary fibrosis with increased severity seen in older…”
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Bats and Coronaviruses by Banerjee, Arinjay, Kulcsar, Kirsten, Misra, Vikram, Frieman, Matthew, Mossman, Karen

“…Bats are speculated to be reservoirs of several emerging viruses including coronaviruses (CoVs) that cause serious disease in humans and agricultural animals…”
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COVID-19: Knowns, Unknowns, and Questions by Weston, Stuart, Frieman, Matthew B

“…The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic…”
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Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2 by Saadat, Saman, Rikhtegaran Tehrani, Zahra, Logue, James, Newman, Michelle, Frieman, Matthew B, Harris, Anthony D, Sajadi, Mohammad M

“…Current shortages in COVID-19 vaccine production and distribution have led some experts to suggest untested regimens. Persons who have had COVID-19 are thought…”
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Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine by Keech, Cheryl, Albert, Gary, Cho, Iksung, Robertson, Andreana, Reed, Patricia, Neal, Susan, Plested, Joyce S, Zhu, Mingzhu, Cloney-Clark, Shane, Zhou, Haixia, Smith, Gale, Patel, Nita, Frieman, Matthew B, Haupt, Robert E, Logue, James, McGrath, Marisa, Weston, Stuart, Piedra, Pedro A, Desai, Chinar, Callahan, Kathleen, Lewis, Maggie, Price-Abbott, Patricia, Formica, Neil, Shinde, Vivek, Fries, Louis, Lickliter, Jason D, Griffin, Paul, Wilkinson, Bethanie, Glenn, Gregory M

“…A recombinant SARS-CoV-2 spike protein nanoparticle vaccine delivered in the deltoid muscle on days 0 and 21 was found to be immunogenic at both 5 μg and 25 μg…”
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Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors by Sisk, Jeanne M, Frieman, Matthew B, Machamer, Carolyn E

“…Enveloped viruses gain entry into host cells by fusing with cellular membranes, a step that is required for virus replication. Coronaviruses, including the…”
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Coronaviruses: important emerging human pathogens by Coleman, Christopher M, Frieman, Matthew B

“…The identification of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 reaffirmed the importance of understanding how coronaviruses emerge,…”
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Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection by Venkataraman, Thiagarajan, Coleman, Christopher M, Frieman, Matthew B

“…Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and mortality in humans. After…”
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Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo by Weston, Stuart, Coleman, Christopher M, Haupt, Robert, Logue, James, Matthews, Krystal, Li, Yize, Reyes, Hanako M, Weiss, Susan R, Frieman, Matthew B

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019 and has rapidly caused a pandemic, with over 20 million…”
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Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion by Coleman, Christopher M, Sisk, Jeanne M, Mingo, Rebecca M, Nelson, Elizabeth A, White, Judith M, Frieman, Matthew B

“…The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) cause significant…”
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NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge by Guebre-Xabier, Mimi, Patel, Nita, Tian, Jing-Hui, Zhou, Bin, Maciejewski, Sonia, Lam, Kristal, Portnoff, Alyse D., Massare, Michael J., Frieman, Matthew B., Piedra, Pedro A., Ellingsworth, Larry, Glenn, Gregory, Smith, Gale

“…•Full-length SARS-CoV-2 prefusion spike with Matrix-M™ (NVX-CoV2373) vaccine.•Induced hACE2 receptor blocking and neutralizing antibodies in macaques.•Vaccine…”
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Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection by Kulcsar, Kirsten A, Coleman, Christopher M, Beck, Sarah E, Frieman, Matthew B

“…Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 in Saudi Arabia and has caused over 2400 cases and more than 800 deaths…”
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Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2 by Schultz, David C., Johnson, Robert M., Ayyanathan, Kasirajan, Miller, Jesse, Whig, Kanupriya, Kamalia, Brinda, Dittmar, Mark, Weston, Stuart, Hammond, Holly L., Dillen, Carly, Ardanuy, Jeremy, Taylor, Louis, Lee, Jae Seung, Li, Minghua, Lee, Emily, Shoffler, Clarissa, Petucci, Christopher, Constant, Samuel, Ferrer, Marc, Thaiss, Christoph A., Frieman, Matthew B., Cherry, Sara

“…The SARS-CoV-2 virus has infected more than 261 million people and has led to more than 5 million deaths in the past year and a half 1 ( https://www.who.org/…”
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Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail by Hansen, Johanna, Baum, Alina, Pascal, Kristen E, Russo, Vincenzo, Giordano, Stephanie, Wloga, Elzbieta, Fulton, Benjamin O, Yan, Ying, Koon, Katrina, Patel, Krunal, Chung, Kyung Min, Hermann, Aynur, Ullman, Erica, Cruz, Jonathan, Rafique, Ashique, Huang, Tammy, Fairhurst, Jeanette, Libertiny, Christen, Malbec, Marine, Lee, Wen-Yi, Welsh, Richard, Farr, Glen, Pennington, Seth, Deshpande, Dipali, Cheng, Jemmie, Watty, Anke, Bouffard, Pascal, Babb, Robert, Levenkova, Natasha, Chen, Calvin, Zhang, Bojie, Romero Hernandez, Annabel, Saotome, Kei, Zhou, Yi, Franklin, Matthew, Sivapalasingam, Sumathi, Lye, David Chien, Weston, Stuart, Logue, James, Haupt, Robert, Frieman, Matthew, Chen, Gang, Olson, William, Murphy, Andrew J, Stahl, Neil, Yancopoulos, George D, Kyratsous, Christos A

“…Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments…”
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Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies by Dyall, Julie, Gross, Robin, Kindrachuk, Jason, Johnson, Reed F., Olinger, Gene G., Hensley, Lisa E., Frieman, Matthew B., Jahrling, Peter B.

“…No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory…”
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CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo by Logue, James, Melville, Victoria M, Ardanuy, Jeremy, Frieman, Matthew B

“…The COVID-19 pandemic has claimed over 6.5 million lives worldwide and continues to have lasting impacts on the world's healthcare and economic systems…”
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Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis by Kindrachuk, Jason, Ork, Britini, Hart, Brit J, Mazur, Steven, Holbrook, Michael R, Frieman, Matthew B, Traynor, Dawn, Johnson, Reed F, Dyall, Julie, Kuhn, Jens H, Olinger, Gene G, Hensley, Lisa E, Jahrling, Peter B

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus, and infections with this virus can result in acute respiratory syndrome…”
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Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection by DYALL, Julie, COLEMAN, Christopher M, JOHANSEN, Lisa M, LEAR-ROONEY, Calli M, GLASS, Pamela J, HENSLEY, Lisa E, FRIEMAN, Matthew B, HART, Brit J, VENKATARAMAN, Thiagarajan, HOLBROOK, Michael R, KINDRACHUK, Jason, JOHNSON, Reed F, OLINGER, Gene G, JAHRLING, Peter B, LAIDLAW, Monique

“…Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic…”
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Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses by Sievers, Benjamin L, Chakraborty, Saborni, Xue, Yong, Gelbart, Terri, Gonzalez, Joseph C, Cassidy, Arianna G, Golan, Yarden, Prahl, Mary, Gaw, Stephanie L, Arunachalam, Prabhu S, Blish, Catherine A, Boyd, Scott D, Davis, Mark M, Jagannathan, Prasanna, Nadeau, Kari C, Pulendran, Bali, Singh, Upinder, Scheuermann, Richard H, Frieman, Matthew B, Vashee, Sanjay, Wang, Taia T, Tan, Gene S

“…Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape…”
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