Search Results - "Friedrich, B. M."

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry by Franken, Holger, Mathieson, Toby, Childs, Dorothee, Sweetman, Gavain M A, Werner, Thilo, Tögel, Ina, Doce, Carola, Gade, Stephan, Bantscheff, Marcus, Drewes, Gerard, Reinhard, Friedrich B M, Huber, Wolfgang, Savitski, Mikhail M

“…Unbiased proteome-level discovery of intracellular drug targets can be achieved by plotting melting curves of proteins from untreated and drug-treated cells…”
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Tracking cancer drugs in living cells by thermal profiling of the proteome by Savitski, Mikhail M., Reinhard, Friedrich B. M., Franken, Holger, Werner, Thilo, Savitski, Maria Fälth, Eberhard, Dirk, Molina, Daniel Martinez, Jafari, Rozbeh, Dovega, Rebecca Bakszt, Klaeger, Susan, Kuster, Bernhard, Nordlund, Pär, Bantscheff, Marcus, Drewes, Gerard

“…The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of…”
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High-precision tracking of sperm swimming fine structure provides strong test of resistive force theory by Friedrich, B M, Riedel-Kruse, I H, Howard, J, Jülicher, F

“…The shape of the flagellar beat determines the path along which a sperm cell swims. If the flagellum bends periodically about a curved mean shape then the…”
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Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs by Unger, Melissa S, Schumacher, Lena, Enzlein, Thomas, Weigt, David, Zamek-Gliszczynski, Maciej J, Schwab, Matthias, Nies, Anne T, Drewes, Gerard, Schulz, Sandra, Reinhard, Friedrich B. M, Hopf, Carsten

“…OATP2B1, a member of the solute carrier (SLC) transporter family, is an important mechanism of substrate drug uptake in the intestine and liver and therefore a…”
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Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space by Unger, Melissa S, Mudunuru, Jennypher, Schwab, Matthias, Hopf, Carsten, Drewes, Gerard, Nies, Anne T, Zamek-Gliszczynski, Maciej J, Reinhard, Friedrich B. M

“…OATP2B1 is an intestinal and hepatic drug uptake transporter. Intestinal OATP2B1 has been elucidated as the mechanism of unexpected clinical drug–drug…”
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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target by Henley, Zoë A, Amour, Augustin, Barton, Nick, Bantscheff, Marcus, Bergamini, Giovanna, Bertrand, Sophie M, Convery, Máire, Down, Kenneth, Dümpelfeld, Birgit, Edwards, Chris D, Grandi, Paola, Gore, Paul M, Keeling, Steve, Livia, Stefano, Mallett, David, Maxwell, Aoife, Price, Mark, Rau, Christina, Reinhard, Friedrich B. M, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Thomas, Daniel A, Hessel, Edith M, Hamblin, J. Nicole

“…Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19…”
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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism by Wellaway, Christopher R, Baldwin, Ian R, Bamborough, Paul, Barker, Daniel, Bartholomew, Michelle A, Chung, Chun-wa, Dümpelfeld, Birgit, Evans, John P, Fazakerley, Neal J, Homes, Paul, Keeling, Steven P, Lewell, Xiao Q, McNab, Finlay W, Morley, Joanne, Needham, Deborah, Neu, Margarete, van Oosterhout, Antoon J. M, Pal, Anshu, Reinhard, Friedrich B. M, Rianjongdee, Francesco, Robertson, Craig M, Rowland, Paul, Shah, Rishi R, Sherriff, Emma B, Sloan, Lisa A, Teague, Simon, Thomas, Daniel A, Wellaway, Natalie, Wojno-Picon, Justyna, Woolven, James M, Coe, Diane M

“…The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in…”
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A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing by Weidemann, Andreas, Eggert, Simone, Reinhard, Friedrich B. M, Vogel, Markus, Paliga, Krzysztof, Baier, Gottfried, Masters, Colin L, Beyreuther, Konrad, Evin, Geneviève

“…Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP) is a key component of Alzheimer's disease pathogenesis. Using…”
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Network permeability changes according to a quadratic power law upon removal of a single edge by Lange, S., Friedrich, B. M.

“…We report a phenomenological power law for the reduction of network permeability in statistically homogeneous spatial networks upon removal of a single edge…”
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Thermal proteome profiling monitors ligand interactions with cellular membrane proteins by Reinhard, Friedrich B M, Eberhard, Dirk, Werner, Thilo, Franken, Holger, Childs, Dorothee, Doce, Carola, Savitski, Maria Fälth, Huber, Wolfgang, Bantscheff, Marcus, Savitski, Mikhail M, Drewes, Gerard

“…A method for profiling changes in membrane protein thermal stability upon ligand binding using mass spectrometry identifies cellular membrane protein targets…”
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The steering gaits of sperm by Gong, A, Rode, S, Kaupp, U B, Gompper, G, Elgeti, J, Friedrich, B M, Alvarez, L

“…Sperm are highly specialized cells, which have been subject to substantial evolutionary pressure. Whereas some sperm features are highly conserved, others have…”
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Reconstruction of the three-dimensional beat pattern underlying swimming behaviors of sperm by Gong, A., Rode, S., Gompper, G., Kaupp, U. B., Elgeti, J., Friedrich, B. M., Alvarez, L.

“… The eukaryotic flagellum propels sperm cells and simultaneously detects physical and chemical cues that modulate the waveform of the flagellar beat. Most…”
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The stochastic dance of circling sperm cells: sperm chemotaxis in the plane by Friedrich, B M, Jülicher, F

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Nematic order by elastic interactions and cellular rigidity sensing by Friedrich, B. M, Safran, S. A

“…We predict spontaneous nematic order in an ensemble of active force generators with elastic interactions as a minimal model for early nematic alignment of…”
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Hydrodynamic synchronization of flagellar oscillators by Friedrich, B. M

“…We survey the theory synchronization in collections of noisy oscillators. This framework is applied to flagellar synchronization by hydrodynamic interactions…”
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Aspartyl Protease Inhibitor Pepstatin Binds to the Presenilins of Alzheimer's Disease by Evin, Geneviève, Sharples, Robyn A, Weidemann, Andreas, Reinhard, Friedrich B. M, Carbone, Vincenzo, Culvenor, Janetta G, Holsinger, R. M. Damian, Sernee, M. Fleur, Beyreuther, Konrad, Masters, Colin L

“…Mutations in the presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease by altering γ-secretase cleavage of the amyloid precursor protein, the last…”
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Working with small molecules: preparing and storing stock solutions and determination of kinetic solubility by Wolf, Andrea, Shimamura, Satoko, Reinhard, Friedrich B M

“…The handling of organic compounds in the laboratory requires the use of organic (co-) solvents to mediate solubility. Advantages and disadvantages of the…”
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In-phase and anti-phase flagellar synchronization by basal coupling by Klindt, G. S, Ruloff, C, Wagner, C, Friedrich, B. M

“…We present a theory of flagellar synchronization in the green alga Chlamydomonas, using full treatment of flagellar hydrodynamics. We find that two recently…”
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Mixed Lithium Magnesium Aryl Oxides Derived from Cresol: Crystal Structures and Solution NMR Studies of an Unexpected, Magnesium-Rich Oxo Product with a Trigonal Bipyramidal LiMg4 Cage and an Expected Lithium-Rich Product with a More Familiar Li.cntdot..cntdot..cntdot.Mg.cntdot..cntdot..cntdot.Li Chain by Henderson, Kenneth W, Mulvey, Robert E, Reinhard, Friedrich B. M, Clegg, William, Horsburgh, Lynne

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Identification of cellular proteins required for replication of human immunodeficiency virus type 1 by Dziuba, Natallia, Ferguson, Monique R, O'Brien, William A, Sanchez, Anthony, Prussia, Andrew J, McDonald, Natalie J, Friedrich, Brian M, Li, Guangyu, Shaw, Michael W, Sheng, Jinsong, Hodge, Thomas W, Rubin, Donald H, Murray, James L

“…Cellular proteins are essential for human immunodeficiency virus type 1 (HIV-1) replication and may serve as viable new targets for treating infection. Using…”
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