Search Results - "Friedman, Steven M."

Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050 by Fridman, Jordan S, Scherle, Peggy A, Collins, Robert, Burn, Timothy C, Li, Yanlong, Li, Jun, Covington, Maryanne B, Thomas, Beth, Collier, Paul, Favata, Margaret F, Wen, Xiaoming, Shi, Jack, McGee, Ryan, Haley, Patrick J, Shepard, Stacey, Rodgers, James D, Yeleswaram, Swamy, Hollis, Greg, Newton, Robert C, Metcalf, Brian, Friedman, Steven M, Vaddi, Kris

“…Inhibiting signal transduction induced by inflammatory cytokines offers a new approach for the treatment of autoimmune diseases such as rheumatoid arthritis…”
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer by Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.

“…We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of heregulin-dependent, HER2-mediated HER3 activation to gefitinib…”
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A multifaceted primary care practice-based intervention to reduce ED visits and hospitalization for complex medical patients: A mixed methods study by O'Brien, Tara, Ivers, Noah, Bhattacharyya, Onil, Calzavara, Andrew, Pus, Laura, Mukerji, Geetha, Friedman, Steven M, Abrams, Howard, Stanaitis, Ian, Hawker, Gillian A, Pariser, Pauline

“…The management of complex, multi-morbid patients is challenging for solo primary care providers (PCPs) with limited access to resources. The primary objective…”
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Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation by Fridman, Jordan S., Scherle, Peggy A., Collins, Robert, Burn, Timothy, Neilan, Claire L., Hertel, Denise, Contel, Nancy, Haley, Patrick, Thomas, Beth, Shi, Jack, Collier, Paul, Rodgers, James D., Shepard, Stacey, Metcalf, Brian, Hollis, Gregory, Newton, Robert C., Yeleswaram, Swamy, Friedman, Steven M., Vaddi, Kris

“…JAKs are required for signaling initiated by several cytokines (e.g., IL-4, IL-12, IL-23, thymic stromal lymphopoietin (TSLP), and IFNγ) implicated in the…”
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Selective Inhibition of ADAM Metalloproteases as a Novel Approach for Modulating ErbB Pathways in Cancer by Fridman, Jordan S, Caulder, Eian, Hansbury, Michael, Liu, Xiangdong, Yang, Genjie, Wang, Qian, Lo, Yvonne, Zhou, Bin-Bing, Pan, Maxwell, Thomas, Sufi M, Grandis, Jennifer R, Zhuo, Jincong, Yao, Wenqing, Newton, Robert C, Friedman, Steven M, Scherle, Peggy A, Vaddi, Kris

“…Purpose: ErbB receptor signaling pathways are important regulators of cell fate, and their dysregulation, through (epi)genetic alterations, plays an etiologic…”
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Safe Cycling: How Do Risk Perceptions Compare With Observed Risk? by Winters, Meghan, Babul, Shelina, Becker, H. J. E. H. (Jack), Brubacher, Jeffrey R., Chipman, Mary, Cripton, Peter, Cusimano, Michael D., Friedman, Steven M., Harris, M. Anne, Hunte, Garth, Monro, Melody, Reynolds, Conor C. O., Shen, Hui, Teschke, Kay

“…Objective:Safety concerns deter cycling. The Bicyclists' Injuries and the Cycling Environment (BICE) study quantified the injury risk associated with 14 route…”
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Personal and trip characteristics associated with safety equipment use by injured adult bicyclists: a cross-sectional study by Teschke, Kay, Brubacher, Jeff R, Friedman, Steven M, Cripton, Peter A, Harris, M Anne, Reynolds, Conor C O, Shen, Hui, Monro, Melody, Hunte, Garth, Chipman, Mary, Cusimano, Michael D, Lea, Nancy Smith, Babul, Shelina, Winters, Meghan

“…The aim of this study was to estimate use of helmets, lights, and visible clothing among cyclists and to examine trip and personal characteristics associated…”
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Route infrastructure and the risk of injuries to bicyclists: a case-crossover study by Teschke, Kay, Harris, M Anne, Reynolds, Conor C O, Winters, Meghan, Babul, Shelina, Chipman, Mary, Cusimano, Michael D, Brubacher, Jeff R, Hunte, Garth, Friedman, Steven M, Monro, Melody, Shen, Hui, Vernich, Lee, Cripton, Peter A

“…We compared cycling injury risks of 14 route types and other route infrastructure features. We recruited 690 city residents injured while cycling in Toronto or…”
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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab by Liu, Xiangdong, Fridman, Jordan S., Wang, Qian, Caulder, Eian, Yang, Gengjie, Covington, Maryanne, Liu, Changnian, Marando, Cindy, Zhuo, Jincong, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Newton, Robert C., Scherle, Peggy A., Friedman, Steven M.

“…The HER-2 receptor tyrosine kinase is an important regulator of cell proliferation and survival, and it is a clinically validated target of therapeutic…”
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COVID-19 vaccine reactogenicity among participants enrolled in the GENCOV study by Morgan, Gregory, Casalino, Selina, Chowdhary, Sunakshi, Frangione, Erika, Fung, Chun Yiu Jordan, Lapadula, Elisa, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Briollais, Laurent, Dagher, Marc, Devine, Luke, Friedman, Steven M, Khan, Zeeshan, Mighton, Chloe, Nirmalanathan, Konika, Richardson, David, Stern, Seth, Taher, Ahmed, Wolday, Dawit, Lerner-Ellis, Jordan, Taher, Jennifer

“…GENCOV is a prospective, observational cohort study of COVID-19-positive adults. Here, we characterize and compare side effects between COVID-19 vaccines and…”
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Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey by Morgan, Gregory, Briollais, Laurent, Clausen, Marc, Casalino, Selina, Mighton, Chloe, Chowdhary, Sunakshi, Frangione, Erika, Fung, Chun Yiu Jordan, Arnoldo, Saranya, Bearss, Erin, Binnie, Alexandra, Borgundvaag, Bjug, Dagher, Marc, Devine, Luke, Friedman, Steven M, Khan, Zeeshan, McGeer, Allison, McLeod, Shelley L, Richardson, David, Stern, Seth, Taher, Ahmed, Wong, Iris, Zarei, Natasha, Bombard, Yvonne, Lerner-Ellis, Jordan, Taher, Jennifer

“…•A survey was conducted to assess public knowledge of SARS-CoV-2 laboratory tests.•Concepts related to SARS-CoV-2 test results were shown to be challenging for…”
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Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile by Kavsak, Peter A., Clark, Lorna, Arnoldo, Saranya, Lou, Amy, Shea, Jennifer L., Eintracht, Shaun, Lyon, Andrew W., Bhayana, Vipin, Thorlacius, Laurel, Raizman, Joshua E., Tsui, Albert, Djiana, Rose, Chen, Michael, Huang, Yun, Haider, Ali, Booth, Ronald A., McCudden, Chris, Yip, Paul M., Beriault, Daniel, Blank, David, Fung, Angela W.S., Taher, Jennifer, St-Cyr, Julie, Sharif, Sameer, Belley-Cote, Emilie, Abramson, Beth L., Friedman, Steven M., Cox, Jafna L., Sivilotti, Marco L.A., Chen-Tournoux, Annabel, McLaren, Jesse, Mak, Susanna, Thiruganasambandamoorthy, Venkatesh, Scheuermeyer, Frank, Humphries, Karin H., Worster, Andrew, Ko, Dennis, Aakre, Kristin M., Mills, Nicholas L., Jaffe, Allan S.

“…An analytical benchmark for high-sensitivity cardiac troponin (hs-cTn) assays is to achieve a coefficient of variation (CV) of ≤ 10.0 % at the 99th percentile…”
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Comparing the effects of infrastructure on bicycling injury at intersections and non-intersections using a case-crossover design by Harris, M Anne, Reynolds, Conor C O, Winters, Meghan, Cripton, Peter A, Shen, Hui, Chipman, Mary L, Cusimano, Michael D, Babul, Shelina, Brubacher, Jeffrey R, Friedman, Steven M, Hunte, Garth, Monro, Melody, Vernich, Lee, Teschke, Kay

“…This study examined the impact of transportation infrastructure at intersection and non-intersection locations on bicycling injury risk. In Vancouver and…”
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Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system by Torzilli, Peter A., Grigiene, Rita, Huang, Charles, Friedman, Steven M., Doty, Stephen B., Boskey, Adele L., Lust, George

“…A new mechanical explant test system was used to study the metabolic response (via proteoglycan biosynthesis) of mature, weight-bearing canine articular…”
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Assay Precision and Risk of Misclassification at Rule-Out Cutoffs for High-Sensitivity Cardiac Troponin by Kavsak, Peter A., Mills, Nicholas L., Clark, Lorna, Ko, Dennis T., Sharif, Sameer, Chen-Tournoux, Annabel, Friedman, Steven M., Belley-Cote, Emilie P., Worster, Andrew, Cox, Jafna, Thiruganasambandamoorthy, Venkatesh, Lou, Amy, Taher, Jennifer, Scheuermeyer, Frank, McCudden, Chris, Abramson, Beth L., Eintracht, Shaun, Shea, Jennifer L., Yip, Paul M., Huang, Yun, Chen, Michael, Tsui, Albert K.Y., Thorlacius, Laurel, Aakre, Kristin M., Raizman, Joshua E., Fung, Angela W.S., Humphries, Karin H., Arnoldo, Saranya, Bhayana, Vipin, Djiana, Rose, Beriault, Daniel R., St-Cyr, Julie, Booth, Ronald A., Blank, David W., Sivilotti, Marco L.A., Jaffe, Allan S.

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Hospital admission from the emergency department for selected emergent diagnoses during the first year of the COVID-19 pandemic in Ontario: a retrospective population-based study by Grewal, Keerat, Atzema, Clare L., Sutradhar, Rinku, Yu, Winnie, Chartier, Lucas B., Friedman, Steven M., Landes, Megan, Borgundvaag, Bjug, McLeod, Shelley L.

“…BACKGROUNDAvoidance of care during the pandemic may have contributed to delays in care, and as a result, worse patient outcomes. We evaluated markers of…”
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Bicycling crash circumstances vary by route type: a cross-sectional analysis by Teschke, Kay, Frendo, Theresa, Shen, Hui, Harris, M Anne, Reynolds, Conor C O, Cripton, Peter A, Brubacher, Jeff, Cusimano, Michael D, Friedman, Steven M, Hunte, Garth, Monro, Melody, Vernich, Lee, Babul, Shelina, Chipman, Mary, Winters, Meghan

“…Widely varying crash circumstances have been reported for bicycling injuries, likely because of differing bicycling populations and environments. We used data…”
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Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study by Morgan, Gregory, Casalino, Selina, Chowdhary, Sunakshi, Frangione, Erika, Fung, Chun Yiu Jordan, Haller, Simona, Lapadula, Elisa, Scott, Mackenzie, Wolday, Dawit, Young, Juliet, Arnoldo, Saranya, Aujla, Navneet, Bearss, Erin, Binnie, Alexandra, Bombard, Yvonne, Borgundvaag, Bjug, Briollais, Laurent, Dagher, Marc, Devine, Luke, Faghfoury, Hanna, Friedman, Steven M, Gingras, Anne-Claude, Goneau, Lee W, Khan, Zeeshan, Mazzulli, Tony, McLeod, Shelley L, Nomigolzar, Romina, Noor, Abdul, Pugh, Trevor J, Richardson, David, Satnam Singh, Harpreet Kaur, Simpson, Jared, Stern, Seth, Strug, Lisa, Taher, Ahmed, Lerner-Ellis, Jordan, Taher, Jennifer

“…The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute…”
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Severity of urban cycling injuries and the relationship with personal, trip, route and crash characteristics: analyses using four severity metrics by Cripton, Peter A, Shen, Hui, Brubacher, Jeff R, Chipman, Mary, Friedman, Steven M, Harris, M Anne, Winters, Meghan, Reynolds, Conor C O, Cusimano, Michael D, Babul, Shelina, Teschke, Kay

“…Objective To examine the relationship between cycling injury severity and personal, trip, route and crash characteristics. Methods Data from a previous study…”
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Birth cohort hepatitis C antibody prevalence in real-world screening settings in Ontario by Biondi, Mia J, Hirode, Grishma, Capraru, Camelia, Vanderhoff, Aaron, Karkada, Joel, Wolfson-Stofko, Brett, Smookler, David, Friedman, Steven M, Bates, Kathy, Mazzulli, Tony, Juan, Joshua V, Shah, Hemant, Hansen, Bettina E, Feld, Jordan J, Janssenc, Harry L.A

“…BACKGROUND: Widespread screening and treatment of hepatitis C virus (HCV) is required to decrease late-stage liver disease and liver cancer. Clinical practice…”
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