Search Results - "Friedman, Robin C."

Most mammalian mRNAs are conserved targets of microRNAs by Friedman, Robin C, Farh, Kyle Kai-How, Burge, Christopher B, Bartel, David P

“…MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed…”
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Widespread haploid-biased gene expression enables sperm-level natural selection by Bhutani, Kunal, Stansifer, Katherine, Ticau, Simina, Bojic, Lazar, Villani, Alexandra-Chloé, Slisz, Joanna, Cremers, Claudia M, Roy, Christian, Donovan, Jerry, Fiske, Brian, Friedman, Robin C

“…Sperm are haploid but must be functionally equivalent to distribute alleles equally among progeny. Accordingly, gene products are shared through spermatid…”
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Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument by Burge, Christopher B, Nutiu, Razvan, Friedman, Robin C, Luo, Shujun, Khrebtukova, Irina, Silva, David, Li, Robin, Zhang, Lu, Schroth, Gary P

“…Several methods for characterizing DNA-protein interactions are available, but none have demonstrated both high throughput and quantitative measurement of…”
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Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture by Bandyopadhyay, Sarmistha, Friedman, Robin C., Marquez, Rebecca T., Keck, Kathy, Kong, Benjamin, Icardi, Michael S., Brown, Kyle E., Burge, Christopher B., Schmidt, Warren N., Wang, Yulei, McCaffrey, Anton P.

“…Background. Chronic hepatitis C virus (HCV)-induced liver fibrosis involves upregulation of transforming growth factor (TGF)-ß and subsequent hepatic stellate…”
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Common and phylogenetically widespread coding for peptides by bacterial small RNAs by Friedman, Robin C, Kalkhof, Stefan, Doppelt-Azeroual, Olivia, Mueller, Stephan A, Chovancová, Martina, von Bergen, Martin, Schwikowski, Benno

“…While eukaryotic noncoding RNAs have recently received intense scrutiny, it is becoming clear that bacterial transcription is at least as pervasive. Bacterial…”
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Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs by JAN, Calvin H, FRIEDMAN, Robin C, RUBY, J. Graham, BARTEL, David P

“…Post-transcriptional gene regulation frequently occurs through elements in mRNA 3' untranslated regions (UTRs). Although crucial roles for 3'UTR-mediated gene…”
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Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs by Jan, Calvin H., Friedman, Robin C., Ruby, J. Graham, Bartel, David P.

“…Cleaning up the transcriptome When genes are transcribed into RNA, the polymerase extends beyond the protein-coding portion to make the 3′ untranslated region…”
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MicroRNA target finding by comparative genomics by Friedman, Robin C, Burge, Christopher B

“…MicroRNAs (miRNAs) have been implicated in virtually every metazoan biological process, exerting a widespread impact on gene expression. MicroRNA repression is…”
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Quantitative assessment of RNA-protein interactions with high-throughput sequencing–RNA affinity profiling by Ozer, Abdullah, Tome, Jacob M, Friedman, Robin C, Gheba, Dan, Schroth, Gary P, Lis, John T

“…This protocol is for high-throughput sequencing–RNA affinity profiling (HiTS-RAP). The technique uses an unmodified Illumina GAIIx sequencer to analyze…”
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Direct visualization of DNA affinity landscapes using a high-throughput sequencing instrument by Nutiu, Razvan, Friedman, Robin C., Luo, Shujun, Khrebtukova, Irina, Silva, David, Li, Robin, Zhang, Lu, Schroth, Gary P., Burge, Christopher B.

“…Sequence-specific DNA binding by transcription factors is central to gene expression regulation. While a number of methods for characterizing DNA-protein…”
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