Search Results - "Friedman, Lauren G."

Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer’s Disease by Friedman, Lauren G., Qureshi, Yasir H., Yu, Wai Haung

“…Many neurodegenerative disorders are characterized by the aberrant accumulation of aggregate-prone proteins. Alzheimer’s disease (AD) is associated with the…”
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Cadherin-Based Transsynaptic Networks in Establishing and Modifying Neural Connectivity by Friedman, Lauren G, Benson, Deanna L, Huntley, George W

“…It is tacitly understood that cell adhesion molecules (CAMs) are critically important for the development of cells, circuits, and synapses in the brain. What…”
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Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits by Friedman, Lauren G., Riemslagh, Fréderike W., Sullivan, Josefa M., Mesias, Roxana, Williams, Frances M., Huntley, George W., Benson, Deanna L.

“…ABSTRACT Neocortical interactions with the dorsal striatum support many motor and executive functions, and such underlying functional networks are particularly…”
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Development and cadherin-mediated control of prefrontal corticostriatal projections in mice by Mesías, Roxana E., Zaki, Yosif, Guevara, Christopher A., Friedman, Lauren G., Hussein, Ayan, Therrien, Karen, Magee, Alexandra R., Tzavaras, Nikolaos, Del Valle, Pamela, Baxter, Mark G., Huntley, George W., Benson, Deanna L.

“…Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon…”
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Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain by Friedman, Lauren G, Lachenmayer, M Lenard, Wang, Jing, He, Liqiang, Poulose, Shibu M, Komatsu, Masaaki, Holstein, Gay R, Yue, Zhenyu

“…Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic…”
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Value-Generating Exploratory Trials in Neurodegenerative Dementias by Friedman, Lauren G., McKeehan, Nicholas, Hara, Yuko, Cummings, Jeffrey L., Matthews, Dawn C., Zhu, Jian, Mohs, Richard C., Wang, Deli, Hendrix, Suzanne B., Quintana, Melanie, Schneider, Lon S., Grundman, Michael, Dickson, Samuel P., Feldman, Howard H., Jaeger, Judith, Finger, Elizabeth C., Ryan, J. Michael, Niehoff, Debra, Dickinson, Susan L-J., Markowitz, Jessica T., Owen, Meriel, Travaglia, Alessio, Fillit, Howard M.

“…Drug development for Alzheimer disease and other neurodegenerative dementias, including frontotemporal dementia, has experienced a long history of phase 2 and…”
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Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers by Snyder, Heather M, Shineman, Diana W, Friedman, Lauren G, Hendrix, James A, Khachaturian, Ara, Le Guillou, Ian, Pickett, James, Refolo, Lorenzo, Sancho, Rosa M, Ridley, Simon H

“…Abstract The reproducibility of laboratory experiments is fundamental to the scientific process. There have been increasing reports regarding challenges in…”
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Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development by Gori, Francesca, Friedman, Lauren G., Demay, Marie B.

“…Wdr5 accelerates osteoblast and chondrocyte differentiation in vitro, and is developmentally expressed in osteoblasts as well as in proliferating and…”
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Optimizing the use of CROs by academia and small companies by Lane, Rachel F., Friedman, Lauren G., Keith, Curtis, Braithwaite, Steven P., Frearson, Julie A., Lowe, David A., Longo, Frank M., Refolo, Lorenzo M., Watterson, D. Martin, Tsaioun, Katya, Shineman, Diana W., Fillit, Howard M.

“…Contract research organizations (CROs) have a key role in drug discovery and development, but processes for evaluating, engaging and managing CRO contracts may…”
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Meeting report on the Alzheimer’s Drug Discovery Foundation 14th International Conference on Alzheimer’s Drug Discovery by Friedman, Lauren G, Price, Katherine, Lane, Rachel F, Carman, Aaron J, Dacks, Penny A, Shineman, Diana W, Fillit, Howard M

“…The Alzheimer's Drug Discovery Foundation's 14th International Conference on Alzheimer's Drug Discovery was held on 9 and 10 September in Jersey City, NJ, USA…”
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Cadherin-8 expression, synaptic localization and molecular control of neuronal form in prefrontal cortico-striatal circuits by Friedman, Lauren G., Riemslagh, Fréderike W., Sullivan, Josefa M., Mesias, Roxana, Williams, Frances M., Huntley, George W., Benson, Deanna L.

“…Neocortical interactions with dorsal striatum support many motor and executive functions, and such underlying functional networks are particularly vulnerable…”
Get full text