Search Results - "Friedman, Jessica E"

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions by Mukherjee, Herschel, Blain, J. Craig, Vandivier, Lee E, Chin, Donovan N, Friedman, Jessica E, Liu, Fei, Maillet, Ashley, Fang, Chao, Kaplan, Jenifer B, Li, Jinxing, Chenoweth, David M, Christensen, Allan Beck, Petersen, Lars Kolster, Hansen, Nils Jakob Vest, Barrera, Luis, Kubica, Neil, Kumaravel, Gnanasambandam, Petter, Jennifer C

“…RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been…”
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Small-Molecule Inhibition of TNF-α by He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.

“…We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The…”
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Iodotyrosine Deiodinase Is the First Mammalian Member of the NADH Oxidase/Flavin Reductase Superfamily by Friedman, Jessica E., Watson, James A., Lam, David W.-H., Rokita, Steven E.

“…The enzyme responsible for iodide salvage in the thyroid, iodotyrosine deiodinase, was solubilized from porcine thyroid microsomes by limited proteolysis with…”
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Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism by Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian

“…BIO8898 is one of several synthetic organic molecules that have recently been reported to inhibit receptor binding and function of the constitutively trimeric…”
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SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model by Fu, Kai, Corbley, Michael J, Sun, Lihong, Friedman, Jessica E, Shan, Feng, Papadatos, James L, Costa, Donald, Lutterodt, Frank, Sweigard, Harry, Bowes, Scott, Choi, Michael, Boriack-Sjodin, P Ann, Arduini, Robert M, Sun, Dongyu, Newman, Miki N, Zhang, Xiamei, Mead, Jonathan N, Chuaqui, Claudio E, Cheung, H-Kam, Zhang, Xin, Cornebise, Mark, Carter, Mary Beth, Josiah, Serene, Singh, Juswinder, Lee, Wen-Cherng, Gill, Alan, Ling, Leona E

“…OBJECTIVE—TGF-β plays a significant role in vascular injury-induced stenosis. This study evaluates the efficacy of a novel, small molecule inhibitor of…”
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Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors by Guckian, Kevin M., Lin, Edward Yin-Shiang, Silvian, Laura, Friedman, Jessica E., Chin, Donovan, Scott, Daniel M.

“…A series of meta-substituted anilines were designed and synthesized to inhibit the interaction of LFA-1 with ICAM for the treatment of autoimmune disease…”
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Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism by Silvian, Laura F, Friedman, Jessica E, Strauch, Kathy, Cachero, Teresa G, Day, Eric S, Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W, Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian

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Structure–activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors by Lin, Edward Yin-Shiang, Guckian, Kevin M., Silvian, Laura, Chin, Donovan, Ann Boriack-Sjodin, P., van Vlijmen, Herman, Friedman, Jessica E., Scott, Daniel M.

“…X-ray co-crystal data assisted the design of LFA-1 ICAM inhibitors based on ortho- and meta-phenol templates, leading to a compound which exploited a new…”
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Transition-State Stabilization by a Mammalian Reductive Dehalogenase by Kunishima, Munetaka, Friedman, Jessica E, Rokita, Steven E

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Small-Molecule Inhibition of TNF-[alpha] by He, Molly M, Smith, Annemarie Stroustrup, Oslob, Johan D, Flanagan, William M, Braisted, Andrew C, Whitty, Adrian, Cancilla, Mark T, Wang, Jun, Lugovskoy, Alexey A, Yoburn, Josh C, Fung, Amy D, Farrington, Graham, Eldredge, John K, Day, Eric S, Cruz, Leslie A, Cachero, Teresa G, Miller, Stephan K, Friedman, Jessica E, Choong, Ingrid C, Cunningham, Brian C

“…We have identified a small-molecule inhibitor of tumor necrosis factor [alpha] (TNF-[alpha]) that promotes subunit disassembly of this trimeric cytokine family…”
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