Search Results - "Friedman, Jacob E"

Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed? by Friedman, Jacob E

“…Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers…”
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Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease by Baker, 2nd, Peter R, Friedman, Jacob E

“…Nonalcoholic fatty liver disease (NAFLD) is a global epidemic in obese children and adults, and the onset might have fetal origins. A growing body of evidence…”
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Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring by Nelson, Benjamin N, Friedman, Jacob E

“…Maternal obesity and over/undernutrition can have a long-lasting impact on offspring health during critical periods in the first 1000 days of life. Children…”
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The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD by Soderborg, Taylor K., Clark, Sarah E., Mulligan, Christopher E., Janssen, Rachel C., Babcock, Lyndsey, Ir, Diana, Young, Bridget, Krebs, Nancy, Lemas, Dominick J., Johnson, Linda K., Weir, Tiffany, Lenz, Laurel L., Frank, Daniel N., Hernandez, Teri L., Kuhn, Kristine A., D’Alessandro, Angelo, Barbour, Linda A., El Kasmi, Karim C., Friedman, Jacob E.

“…Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this…”
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Maternal obesity and fetal metabolic programming: a fertile epigenetic soil by Heerwagen, Margaret J R, Miller, Melissa R, Barbour, Linda A, Friedman, Jacob E

“…The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the…”
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Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project by Boyle, Kristen E, Patinkin, Zachary W, Shapiro, Allison L B, Baker, 2nd, Peter R, Dabelea, Dana, Friedman, Jacob E

“…Maternal obesity increases the risk for pediatric obesity; however, the molecular mechanisms in human infants remain poorly understood. We hypothesized that…”
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Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes by Barbour, Linda A, McCurdy, Carrie E, Hernandez, Teri L, Kirwan, John P, Catalano, Patrick M, Friedman, Jacob E

“…Infusion of TNF-α results in increased insulin resistance in rat and human skeletal muscle cells incubated in culture (21), although TNF-α neutralization over…”
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Spaceflight Activates Lipotoxic Pathways in Mouse Liver by Jonscher, Karen R, Alfonso-Garcia, Alba, Suhalim, Jeffrey L, Orlicky, David J, Potma, Eric O, Ferguson, Virginia L, Bouxsein, Mary L, Bateman, Ted A, Stodieck, Louis S, Levi, Moshe, Friedman, Jacob E, Gridley, Daila S, Pecaut, Michael J

“…Spaceflight affects numerous organ systems in the body, leading to metabolic dysfunction that may have long-term consequences. Microgravity-induced alterations…”
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Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation by Kendrick, Agnieszka A, Choudhury, Mahua, Rahman, Shaikh M, McCurdy, Carrie E, Friederich, Marisa, Van Hove, Johan L K, Watson, Peter A, Birdsey, Nicholas, Bao, Jianjun, Gius, David, Sack, Michael N, Jing, Enxuan, Kahn, C Ronald, Friedman, Jacob E, Jonscher, Karen R

“…Acetylation has recently emerged as an important mechanism for controlling a broad array of proteins mediating cellular adaptation to metabolic fuels…”
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Early Microbes Modify Immune System Development and Metabolic Homeostasis-The "Restaurant" Hypothesis Revisited by Nash, Michael J, Frank, Daniel N, Friedman, Jacob E

“…The developing infant gut microbiome affects metabolism, maturation of the gastrointestinal tract, immune system function, and brain development. Initial…”
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Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and Potential Molecular Mechanisms by Mandala, Ashok, Janssen, Rachel C, Palle, Sirish, Short, Kevin R, Friedman, Jacob E

“…Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide and is estimated to affect nearly 40% of obese youth and up to 10%…”
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Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension by El Kasmi, Karim C, Pugliese, Steven C, Riddle, Suzette R, Poth, Jens M, Anderson, Aimee L, Frid, Maria G, Li, Min, Pullamsetti, Soni S, Savai, Rajkumar, Nagel, Maria A, Fini, Mehdi A, Graham, Brian B, Tuder, Rubin M, Friedman, Jacob E, Eltzschig, Holger K, Sokol, Ronald J, Stenmark, Kurt R

“…Macrophage accumulation is not only a characteristic hallmark but is also a critical component of pulmonary artery remodeling associated with pulmonary…”
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C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis by Payne, Victoria A, Au, Wo-Shing, Lowe, Christopher E, Rahman, Shaikh M, Friedman, Jacob E, O'Rahilly, Stephen, Rochford, Justin J

“…The transcription factor SREBP1c (sterol-regulatory-element-binding protein 1c) is highly expressed in adipose tissue and plays a central role in several…”
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A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates by Suter, Melissa A., Chen, Aishe, Burdine, Marie S., Choudhury, Mahua, Harris, R. Alan, Lane, Robert H., Friedman, Jacob E., Grove, Kevin L., Tackett, Alan J., Aagaard, Kjersti M.

“…In nonhuman primates, we previously demonstrated that a maternal high‐fat diet (MHFD) induces fetal nonalcoholic fatty liver disease (NAFLD) and alters the…”
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Hepatitis C virus infection: Molecular pathways to metabolic syndrome by Sheikh, Muhammad Y., Choi, Jinah, Qadri, Ishtiaq, Friedman, Jacob E., Sanyal, Arun J.

“…Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a genotype‐dependent fashion, thus contributing to steatosis, progression…”
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Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes by Zhang, Li, Jonscher, Karen R., Zhang, Zuyuan, Xiong, Yi, Mueller, Ryan S., Friedman, Jacob E., Pan, Chongle

“…The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against…”
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Maternal Fuels and Metabolic Measures During Pregnancy and Neonatal Body Composition: The Healthy Start Study by Crume, Tessa L, Shapiro, Allison L, Brinton, John T, Glueck, Deborah H, Martinez, Mercedes, Kohn, Mary, Harrod, Curtis, Friedman, Jacob E, Dabelea, Dana

“…Context: The impact of specific maternal fuels and metabolic measures during early and late gestation on neonatal body composition is not well defined…”
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Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates by THORN, Stephanie R, BAQUERO, Karalee C, NEWSOM, Sean A, EL KASMI, Karim C, BERGMAN, Bryan C, SHULMAN, Gerald I, GROVE, Kevin L, FRIEDMAN, Jacob E

“…The origins of nonalcoholic fatty liver disease (NAFLD) may lie in early intrauterine exposures. Here we examined the maternal response to chronic maternal…”
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Intrahepatic Fat Is Increased in the Neonatal Offspring of Obese Women with Gestational Diabetes by Brumbaugh, David E., MD, Tearse, Phillip, Cree-Green, Melanie, MD, PhD, Fenton, Laura Z., MD, Brown, Mark, PhD, Scherzinger, Ann, MD, Reynolds, Regina, MD, Alston, Meredith, MD, Hoffman, Camille, MD, Pan, Zhaoxing, PhD, Friedman, Jacob E., PhD, Barbour, Linda A., MD, MSPH

“…Objectives To assess precision magnetic resonance imaging in the neonate and determine whether there is an early maternal influence on the pattern of neonatal…”
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TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis by Matye, David, Gunewardena, Sumedha, Chen, Jianglei, Wang, Huaiwen, Wang, Yifeng, Hasan, Mohammad Nazmul, Gu, Lijie, Clayton, Yung Dai, Du, Yanhong, Chen, Cheng, Friedman, Jacob E., Lu, Shelly C., Ding, Wen-Xing, Li, Tiangang

“…Fatty liver is a highly heterogenous condition driven by various pathogenic factors in addition to the severity of steatosis. Protein insufficiency has been…”
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