Search Results - "Friedman, Eitan A."

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease by Friedman, Eitan A, Ogletree, Martin L, Haddad, Elias V, Boutaud, Olivier

“…Abstract The platelet thrombus is the major pathologic entity in acute coronary syndromes, and antiplatelet agents are a mainstay of therapy. However,…”
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Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis by Swiger, Kristopher J., Friedman, Eitan A., Brittain, Evan L., Tomasek, Kelsey A., Huang, Shi, Su, Yan R., Sawyer, Douglas B., Lenihan, Daniel J.

“…Background: Cardiac amyloidosis is an infiltrative cardiomyopathy that is challenging to diagnose. We hypothesized that the novel biomarkers hepatocyte growth…”
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Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade by Kurnik, Daniel, Li, Chun, Sofowora, Gbenga G, Friedman, Eitan A, Muszkat, Mordechai, Xie, Hong-Guang, Harris, Paul A, Williams, Scott M, Nair, Usha B, Wood, Alastair J.J, Stein, C Michael

“…OBJECTIVESBlack patients may be less responsive to β-blockers than whites. Genetic variants in the β1-adrenergic receptor (β1-AR) associated with lesser…”
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Ethnic and Genetic Determinants of Cardiovascular Response to the Selective α2-Adrenoceptor Agonist Dexmedetomidine by Kurnik, Daniel, Muszkat, Mordechai, Sofowora, Gbenga G, Friedman, Eitan A, Dupont, William D, Scheinin, Mika, Wood, Alastair J.J, Stein, C Michael

“…The α2-adrenoceptor agonist clonidine reduces blood pressure more effectively in White than Black Americans despite similar degrees of sympatholysis…”
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Effects of variation in the human α2A - and α2C -adrenoceptor genes on cognitive tasks and pain perception by Kohli, Utkarsh, Muszkat, Mordechai, Sofowora, Gbenga G, Harris, Paul A, Friedman, Eitan A, Dupont, William D, Scheinin, Mika, Wood, Alastair J.J, Stein, C. Michael, Kurnik, Daniel

“…Abstract Background The mechanisms underlying interindividual variability in pain perception and cognitive responses are undefined but highly heritable. α2C -…”
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CYP2A6 genetic variation and dexmedetomidine disposition by Kohli, Utkarsh, Pandharipande, Pratik, Muszkat, Mordechai, Sofowora, Gbenga G., Friedman, Eitan A., Scheinin, Mika, Wood, Alastair J. J., Ely, E. Wesley, Tyndale, Rachel F., Choi, Leena, Stein, C. Michael, Kurnik, Daniel

“…Purpose There is a large interindividual variability in dexmedetomidine dose requirements for sedation of patients in intensive care units (ICU). Cytochrome…”
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Elevated Hepatocyte Growth Factor is Associated With Worse Prognosis in Cardiac Amyloidosis by Friedman, Eitan A, Tomasek, Kelsey, Su, Yan Ru, Sawyer, Douglas B, Lenihan, Daniel J

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Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention by Friedman, Eitan A., Texeira, Luisa, Delaney, Jessica, Weeke, Peter E., Lynch, Donald R., Kasasbeh, Ehab, Song, Yanna, Harrell, Frank E., Denny, Josh C., Hamm, Heidi E., Roden, Dan M., Cleator, John H.

“…Abnormal platelet reactivity is associated with recurrent ischemia and bleeding following percutaneous coronary intervention (PCI). Protease-activated…”
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Markedly Elevated Galectin-3 Levels in Cardiac Amyloidosis May Indicate Significant Fibrosis by Friedman, Eitan A, Brittain, Evan, Su, Yan Ru, LeBoeuf, Jared, Sawyer, Douglas, Lenihan, Daniel

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Elevated Plasma Interleukin-6, Endothelin-1, and Matrix Metalloproteinase-9 in Heart Failure Patients are Associated With the Need for Advanced Therapies and Mortality by Friedman, Eitan A, Egolum, Ugochukwu O, Shisler, David C, Todd, John A, Estis, Joel, Nolan, Niamh, Shah, Adnan, Lenihan, Daniel J

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Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise by Ghimire, Laxmi V, Kohli, Utkarsh, Li, Chun, Sofowora, Gbenga G, Muszkat, Mordechai, Friedman, Eitan A, Solus, Joseph F, Wood, Alastair J.J, Stein, C Michael, Kurnik, Daniel

“…OBJECTIVETo examine the hypothesis that genetic variation in enzymes and transporters associated with synthesis, storage, release, and metabolism of…”
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Endothelin-1 Is Independently Associated with the Annual Risk of Heart Failure Hospitalization by Friedman, Eitan A, Shisler, David C, Todd, John A, Estis, Joel, Shah, Adnan, Nolan, Niamh, Lenihan, Daniel J

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Genetic Variations in the α2A-Adrenoreceptor Are Associated With Blood Pressure Response to the Agonist Dexmedetomidine by Kurnik, Daniel, Muszkat, Mordechai, Li, Chun, Sofowora, Gbenga G, Friedman, Eitan A, Scheinin, Mika, Wood, Alastair J.J, Stein, C Michael

“…BACKGROUND—α2A-Adrenoceptors (α2A-ARs) have important roles in sympathetic cardiovascular regulation. Variants of ADRA2A affect gene transcription and…”
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Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine by Kurnik, Daniel, Muszkat, Mordechai, Li, Chun, Sofowora, Gbenga G, Friedman, Eitan A, Scheinin, Mika, Wood, Alastair J J, Stein, C Michael

“…α(2A)-Adrenoceptors (α(2A)-ARs) have important roles in sympathetic cardiovascular regulation. Variants of ADRA2A affect gene transcription and expression and…”
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A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records by Lee, Hee-Jin, Jiang, Min, Wu, Yonghui, Shaffer, Christian M, Cleator, John H, Friedman, Eitan A, Lewis, Joshua P, Roden, Dan M, Denny, Josh, Xu, Hua

“…Electronic health records (EHRs) linked with biobanks have been recognized as valuable data sources for pharmacogenomic studies, which require identification…”
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Genetic variants in the α2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses by Kurnik, Daniel, Friedman, Eitan A, Muszkat, Mordechai, Sofowora, Gbenga G, Xie, Hong-Guang, Dupont, William D, Wood, Alastair J.J, Michael Stein, C

“…OBJECTIVESCardiovascular responses to stressors are regulated by sympathetic activity, increased in black Americans, and associated with future cardiovascular…”
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GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans by Kurnik, Daniel, Cunningham, Andrew J, Sofowora, Gbenga G, Kohli, Utkarsh, Li, Chun, Friedman, Eitan A, Muszkat, Mordechai, Menon, Usha B, Wood, Alastair Jj, Stein, C Michael

“…A common, functionally significant polymorphism in GRK5 (Gln41Leu) encodes a gain-of-function enzyme that enhances desensitization of the beta(1)-adrenergic…”
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Effect of the α2C-adrenoreceptor deletion322–325 variant on sympathetic activity and cardiovascular measures in healthy subjects by Kurnik, Daniel, Muszkat, Mordechai, Friedman, Eitan A, Sofowora, Gbenga G, Diedrich, André, Xie, Hong-Guang, Harris, Paul A, Choi, Leena, Wood, Alastair JJ, Stein, C Michael

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Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine by Kurnik, Daniel, Muszkat, Mordechai, Sofowora, Gbenga G, Friedman, Eitan A, Dupont, William D, Scheinin, Mika, Wood, Alastair J J, Stein, C Michael

“…The alpha(2)-adrenoceptor agonist clonidine reduces blood pressure more effectively in White than Black Americans despite similar degrees of sympatholysis…”
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Abstract 39: Platelet Reactivity to Prostaglandin E2 is a Novel Modifiable Risk Factor for St-Elevation Myocardial Infarction by Friedman, Eitan A, Haddad, Elias V, Joksas, Valentinas, Huang, Shi, Xu, Meng, Boutaud, Olivier

“…Abstract only Background: Patients with lower thresholds for platelet activation are at increased risk for primary and recurrent myocardial infarction (MI) and…”
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