Search Results - "Friedman, Carol"

Detection of drug-drug interactions through data mining studies using clinical sources, scientific literature and social media by Vilar, Santiago, Friedman, Carol, Hripcsak, George

“…Abstract Drug-drug interactions (DDIs) constitute an important concern in drug development and postmarketing pharmacovigilance. They are considered the cause…”
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Similarity-based modeling in large-scale prediction of drug-drug interactions by Vilar, Santiago, Uriarte, Eugenio, Santana, Lourdes, Lorberbaum, Tal, Hripcsak, George, Friedman, Carol, Tatonetti, Nicholas P

“…The authors of this protocol describe a similarity-based, large-scale approach to predicting novel drug-drug interactions (DDIs) integrating a reference…”
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Drug-drug interaction through molecular structure similarity analysis by Vilar, Santiago, Harpaz, Rave, Uriarte, Eugenio, Santana, Lourdes, Rabadan, Raul, Friedman, Carol

“…Drug-drug interactions (DDIs) are responsible for many serious adverse events; their detection is crucial for patient safety but is very challenging…”
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Mining multi-item drug adverse effect associations in spontaneous reporting systems by Harpaz, Rave, Chase, Herbert S, Friedman, Carol

“…Multi-item adverse drug event (ADE) associations are associations relating multiple drugs to possibly multiple adverse events. The current standard in…”
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Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients by Freedberg, Daniel E, Salmasian, Hojjat, Friedman, Carol, Abrams, Julian A

“…Observational studies suggest that proton pump inhibitors (PPIs) are a risk factor for incident Clostridium difficile infection (CDI). Data also suggest an…”
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Deep Phenotyping on Electronic Health Records Facilitates Genetic Diagnosis by Clinical Exomes by Son, Jung Hoon, Xie, Gangcai, Yuan, Chi, Ena, Lyudmila, Li, Ziran, Goldstein, Andrew, Huang, Lulin, Wang, Liwei, Shen, Feichen, Liu, Hongfang, Mehl, Karla, Groopman, Emily E., Marasa, Maddalena, Kiryluk, Krzysztof, Gharavi, Ali G., Chung, Wendy K., Hripcsak, George, Friedman, Carol, Weng, Chunhua, Wang, Kai

“…Integration of detailed phenotype information with genetic data is well established to facilitate accurate diagnosis of hereditary disorders. As a rich source…”
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Detection of drug-drug interactions by modeling interaction profile fingerprints by Vilar, Santiago, Uriarte, Eugenio, Santana, Lourdes, Tatonetti, Nicholas P, Friedman, Carol

“…Drug-drug interactions (DDIs) constitute an important problem in postmarketing pharmacovigilance and in the development of new drugs. The effectiveness or…”
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Using Rich Data on Comorbidities in Case-Control Study Design with Electronic Health Record Data Improves Control of Confounding in the Detection of Adverse Drug Reactions by Backenroth, Daniel, Chase, Herbert, Friedman, Carol, Wei, Ying

“…Recent research has suggested that the case-control study design, unlike the self-controlled study design, performs poorly in controlling confounding in the…”
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Combing signals from spontaneous reports and electronic health records for detection of adverse drug reactions by Harpaz, Rave, Vilar, Santiago, Dumouchel, William, Salmasian, Hojjat, Haerian, Krystl, Shah, Nigam H, Chase, Herbert S, Friedman, Carol

“…Data-mining algorithms that can produce accurate signals of potentially novel adverse drug reactions (ADRs) are a central component of pharmacovigilance. We…”
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Automated encoding of clinical documents based on natural language processing by Friedman, Carol, Shagina, Lyudmila, Lussier, Yves, Hripcsak, George

“…The aim of this study was to develop a method based on natural language processing (NLP) that automatically maps an entire clinical document to codes with…”
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Annual Report to the Nation on the Status of Cancer, 1975–2002, Featuring Population-Based Trends in Cancer Treatment by Edwards, Brenda K., Brown, Martin L., Wingo, Phyllis A., Howe, Holly L., Ward, Elizabeth, Ries, Lynn A. G., Schrag, Deborah, Jamison, Patricia M., Jemal, Ahmedin, Wu, Xiao Cheng, Friedman, Carol, Harlan, Linda, Warren, Joan, Anderson, Robert N., Pickle, Linda W.

“…Background: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North…”
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A two-site survey of medical center personnel's willingness to share clinical data for research: implications for reproducible health NLP research by Weng, Chunhua, Friedman, Carol, Rommel, Casey A, Hurdle, John F

“…A shareable repository of clinical notes is critical for advancing natural language processing (NLP) research, and therefore a goal of many NLP researchers is…”
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A method for controlling complex confounding effects in the detection of adverse drug reactions using electronic health records by Li, Ying, Salmasian, Hojjat, Vilar, Santiago, Chase, Herbert, Friedman, Carol, Wei, Ying

“…Electronic health records (EHRs) contain information to detect adverse drug reactions (ADRs), as they contain comprehensive clinical information. A major…”
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Enhancing adverse drug event detection in electronic health records using molecular structure similarity: application to pancreatitis by Vilar, Santiago, Harpaz, Rave, Santana, Lourdes, Uriarte, Eugenio, Friedman, Carol

“…Adverse drug events (ADEs) detection and assessment is at the center of pharmacovigilance. Data mining of systems, such as FDA's Adverse Event Reporting System…”
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Monitoring prescribing patterns using regression and electronic health records by Backenroth, Daniel, Chase, Herbert S, Wei, Ying, Friedman, Carol

“…It is beneficial for health care institutions to monitor physician prescribing patterns to ensure that high-quality and cost-effective care is being provided…”
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GENIES: a natural-language processing system for the extraction of molecular pathways from journal articles by Friedman, C, Kra, P, Yu, H, Krauthammer, M, Rzhetsky, A

“…Systems that extract structured information from natural language passages have been highly successful in specialized domains. The time is opportune for…”
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Discovering disease associations by integrating electronic clinical data and medical literature by Holmes, Antony B, Hawson, Alexander, Liu, Feng, Friedman, Carol, Khiabanian, Hossein, Rabadan, Raul

“…Electronic health record (EHR) systems offer an exceptional opportunity for studying many diseases and their associated medical conditions within a population…”
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Predicting monoamine oxidase inhibitory activity through ligand-based models by Vilar, Santiago, Ferino, Giulio, Quezada, Elias, Santana, Lourdes, Friedman, Carol

“…The evolution of bio- and cheminformatics associated with the development of specialized software and increasing computer power has produced a great interest…”
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Descriptive epidemiology of colorectal cancer in the United States, 1998–2001 by Jackson‐Thompson, Jeannette, Ahmed, Faruque, German, Robert R., Lai, Sue‐Min, Friedman, Carol

“…This article presents an overview of the descriptive epidemiology of colorectal cancer (CRC) in the United States and provides detailed methodologic…”
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State of the art and development of a drug-drug interaction large scale predictor based on 3D pharmacophoric similarity by Vilar, Santiago, Uriarte, Eugenio, Santana, Lourdes, Friedman, Carol, Tatonetti, Nicholas P

“…Co-administration of drugs is a primary cause of Adverse Drug Reactions (ADRs) and a drain on the health care industry costing billions of dollars and reducing…”
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