Search Results - "Friedland, Julie C"

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer by Sang, Jim, Acquaviva, Jaime, Friedland, Julie C, Smith, Donald L, Sequeira, Manuel, Zhang, Chaohua, Jiang, Qin, Xue, Liquan, Lovly, Christine M, Jimenez, John-Paul, Shaw, Alice T, Doebele, Robert C, He, Suqin, Bates, Richard C, Camidge, D Ross, Morris, Stephan W, El-Hariry, Iman, Proia, David A

“…EML4-ALK gene rearrangements define a unique subset of patients with non-small cell lung carcinoma (NSCLC), and the clinical success of the anaplastic lymphoma…”
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Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression by HE, SUQIN, ZHANG, CHAOHUA, SHAFI, AYESHA A, SEQUEIRA, MANUEL, ACQUAVIVA, JAIME, FRIEDLAND, JULIE C, SANG, JIM, SMITH, DONALD L, WEIGEL, NANCY L, WADA, YUMIKO, PROIA, DAVID A

“…Androgen ablation therapy represents the first line of therapeutic intervention in men with advanced or recurrent prostate tumors. However, the incomplete…”
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Norepinephrine-Deficient Mice Lack Responses to Antidepressant Drugs, Including Selective Serotonin Reuptake Inhibitors by Cryan, John F., O'Leary, Olivia F., Jin, Sung-Ha, Friedland, Julie C., Ouyang, Ming, Hirsch, Bradford R., Page, Michelle E., Dalvi, Ashutosh, Thomas, Steven A., Lucki, Irwin, McEwen, Bruce S.

“…Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine β-hydroxylase gene, Dbh, were used to critically test…”
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Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini by Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

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Mechanically Activated Integrin Switch Controls α₅β₁ Function by Friedland, Julie C, Lee, Mark H, Boettiger, David

“…The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are…”
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Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib by Acquaviva, Jaime, Smith, Donald L, Sang, Jim, Friedland, Julie C, He, Suqin, Sequeira, Manuel, Zhang, Chaohua, Wada, Yumiko, Proia, David A

“…Mutant KRAS is a feature of more than 25% of non-small cell lung cancers (NSCLC) and represents one of the most prevalent oncogenic drivers in this disease…”
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Case report: response to the ERK1/2 inhibitor ulixertinib in BRAF D594G cutaneous melanoma by Wolfe, Zachary, Friedland, Julie C., Ginn, Sarah, Blackham, Aaron, Demberger, Lauren, Horton, Morgan, McIntosh, Alyson, Sheikh, Hina, Box, Jessica, Knoerzer, Deborah, Federowicz, Bryan, Stuhlmiller, Timothy J., Shapiro, Mark, Nair, Suresh

“…Melanoma is characterized by oncogenic mutations in pathways regulating cell growth, proliferation, and metabolism. Greater than 80% of primary melanoma cases…”
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Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes by Friedland, Julie C., Smith, Donald L., Sang, Jim, Acquaviva, Jaime, He, Suqin, Zhang, Chaohua, Proia, David A.

“…Summary Heat shock protein 90 (Hsp90) is a molecular chaperone essential for the stability and function of multiple cellular client proteins, a number of which…”
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alpha 6 beta 4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- Kappa B-dependent resistance to apoptosis in 3D mammary acini by Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

“…Malignant transformation and multidrug resistance are linked to resistance to apoptosis, yet the molecular mechanisms that mediate tumor survival remain poorly…”
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α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini by Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

“…Malignant transformation and multidrug resistance are linked to resistance to apoptosis, yet the molecular mechanisms that mediate tumor survival remain poorly…”
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Traumatic brain injury elevates glycogen and induces tolerance to ischemia in rat brain by Otori, Tatsuo, Friedland, Julie C, Sinson, Grant, McIntosh, Tracy K, Raghupathi, Ramesh, Welsh, Frank A

“…Previous studies have demonstrated that traumatic brain injury (TBI) increases the vulnerability of the brain to an acute episode of hypoxia-ischemia. The…”
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Clinical utility of an international multidisciplinary virtual tumor board for fibrolamellar carcinoma by Kent, Paul, Tasse, Jordan C., Schadde, Erik, Kato, Tomoaki, Humar, Abhinav, Fisher, Oliver M., Dixon, Matthew, Yamashiro, Darrell, Cornelius, Albert, Royall, Nelson Andrew, Kim, Thomas, Friedland, Julie C., Stuhlmiller, Timothy Joseph, Awawda, Alaa, Sabates, Alanis, Shapiro, Mark Adam, Ellison, Jessica, Stockwell, Tom

“…e18624 Background: Fibrolamellar carcinoma (FLC) is a rare liver cancer with approximately 1500 new cases per year, worldwide. The lack of expertise locally…”
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Case report: response to the ERK1/2 inhibitor ulixertinib in BRAF D594G cutaneous melanoma by Wolfe, Zachary, Friedland, Julie C., Ginn, Sarah, Blackham, Aaron, Demberger, Lauren, Horton, Morgan, McIntosh, Alyson, Sheikh, Hina, Box, Jessica, Knoerzer, Deborah, Federowicz, Bryan, Stuhlmiller, Timothy J., Shapiro, Mark, Nair, Suresh

“…Melanoma is characterized by oncogenic mutations in pathways regulating cell growth, proliferation, and metabolism. Greater than 80% of primary melanoma cases…”
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Abstract 1038: Inhibition of mTOR enhances the activity of HSP90 inhibitors in part through cessation of heat shock protein synthesis by He, Suqin, Acquaviva, Jaime, Friedland, Julie C., Sang, Jim, Smith, Donald L., Sequeira, Manuel, Zhang, Chaohua, Proia, David A.

“…Background: Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability of hundreds of client proteins, many of which promote tumor…”
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Mechanically Activated Integrin Switch Controls α 5 β 1 Function by Friedland, Julie C., Lee, Mark H., Boettiger, David

“…The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are…”
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Mechanically Activated Integrin Switch Controls [alpha]5[beta]1 Function by Friedland, Julie C, Lee, Mark H, Boettiger, David

“…The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are…”
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Preclinical activity of the Hsp90 inhibitor, ganetespib, in ALK- and ROS1-driven cancers by Proia, David A, Acquaviva, Jaime, Jiang, Qin, Xue, Liquan, Smith, Donald, Friedland, Julie C, He, Suqin, Sang, Jim, Morris, Stephan, Wada, Yumiko

“…Abstract only 3090 Background: Ganetespib is a potent inhibitor of heat shock protein 90 (Hsp90) currently being studied in a broad range of clinical trials…”
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alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini by Friedland, Julie C, Lakins, Johnathon N, Kazanietz, Marcelo G, Chernoff, Jonathan, Boettiger, David, Weaver, Valerie M

“…Malignant transformation and multidrug resistance are linked to resistance to apoptosis, yet the molecular mechanisms that mediate tumor survival remain poorly…”
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Mechanically activated integrin switch controls alpha5beta1 function by Friedland, Julie C, Lee, Mark H, Boettiger, David

“…The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are…”
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Spatial-mechanical regulation of the small GTPase Rac in mammary epithelial cell survival and apoptosis resistance by Friedland, Julie C

“…Cells in vivo exist in a three-dimensional (3D) compliant microenvironment, and stromal-epithelial interactions regulate mammary morphogenesis and modulate…”
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