Search Results - "Friedberg, T"

In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids by Breinholt, V.M, Offord, E.A, Brouwer, C, Nielsen, S.E, Brøsen, K, Friedberg, T

“…Human and mouse liver microsomes and membranes isolated from Escherichia coli, which expressed cytochrome P450 (CYP) 1A2, 3A4, 2C9 or 2D6, were used to…”
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Enlarged parietal foramina: findings on prenatal ultrasound and magnetic resonance imaging by Chung, H. Y. B., Uster‐Friedberg, T., Pentaz, S., Blaser, S., Murphy, K., Chitayat, D.

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The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19 by HÄRTTER, Sebastian, TYBRING, Gunnel, FRIEDBERG, Thomas, WEIGMANN, Harald, HIEMKE, Christoph

“…This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant…”
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Expression and alternative splicing of the cytochrome P-450 CYP2A7 by Ding, S, Lake, B G, Friedberg, T, Wolf, C R

“…In order to investigate the relative levels of expression of human cytochrome P-450 (P-450) CYP2A genes and determine how this relates to polymorphism in…”
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Refinement of the Region for Split Hand/Foot Malformation 5 on 2q31.1 by Theisen, A., Rosenfeld, J.A., Shane, K., McBride, K.L., Atkin, J.F., Gaba, C., Hoo, J., Kurczynski, T.W., Schnur, R.E., Coffey, L.B., Zackai, E.H., Schimmenti, L., Friedman, N., Zabukovec, M., Ball, S., Pagon, R., Lucas, A., Brasington, C.K., Spence, J.E., Sparks, S., Banks, V., Smith, W., Friedberg, T., Wyatt, P.R., Aust, M., Tervo, R., Crowley, A., Skidmore, D., Lamb, A.N., Ravnan, B., Sahoo, T., Schultz, R., Torchia, B.S., Sgro, M., Chitayat, D., Shaffer, L.G.

“…Background: Deletions that encompass 2q31.1 have been proposed as a microdeletion syndrome with common clinical features, including intellectual…”
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Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells by Andrews, J., Abd-Ellah, M. F., Randolph, N. L., Kenworthy, K. E., Carlile, D. J., Friedberg, T., Houston, J. B.

“…1. The aim was to compare the metabolic activity of human CYP3A4 expressed in bacteria (E. coli), yeast (S. cerevisiae) and human lymphoblastoid cells (hBl),…”
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Stable Expression of Rat Cytochrome P-450IIB1 cDNA in Chinese Hamster Cells (V79) and Metabolic Activation of Aflatoxin B1 by Doehmer, Johannes, Dogra, Satish, Friedberg, Thomas, Monier, Solange, Adesnik, Milton, Glatt, Hansruedi, Oesch, Franz

“…V79 Chinese hamster fibroblasts are widely used for mutagenicity testing but have the serious limitation that they do not express cytochromes P-450, which are…”
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Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers by Friedberg, T

“…The development of cancers of the breast, endometrium, ovaries and possibly prostate is modulated by steroid hormones. Many steroids and environmental…”
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Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways by Ding, S, Yao, D, Deeni, Y Y, Burchell, B, Wolf, C R, Friedberg, T

“…NADPH-P450 oxidoreductase (CPR) is essential for the activity of cytochrome P450 (P450). Previous studies demonstrated that CPR regulates the levels of various…”
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MERITS AND LIMITATIONS OF RECOMBINANT MODELS FOR THE STUDY OF HUMAN P450-MEDIATED DRUG METABOLISM AND TOXICITY: AN INTRALABORATORY COMPARISON by FRIEDBERG, T., PRITCHARD, M. P., BANDERA, M., HANLON, S. P., YAO, D., McLAUGHLIN, L. A., DING, S., BURCHELL, B., WOLF, C. R.

“…A wide variety of pharmacological and toxicological properties of drugs are determined by cytochrome P450-mediated metabolism. Characterization of these…”
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The microsomal epoxide hydrolase has a single membrane signal anchor sequence which is dispensable for the catalytic activity of this protein by Friedberg, T, Löllmann, B, Becker, R, Holler, R, Oesch, F

“…The microsomal epoxide hydrolase (mEH) catalyses the hydrolysis of reactive epoxides which are formed by the action of cytochromes P-450 from xenobiotics. In…”
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Relationship between the microsomal epoxide hydrolase and the hepatocellular transport of bile acids and xenobiotics by Honscha, W, Platte, H D, Oesch, F, Friedberg, T

“…Recently two different bile-acid carriers for the hepatocellular sodium-dependent uptake of taurocholate have been described. The first transport system was…”
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Recombinant in vitro tools to predict drug metabolism and safety by Friedberg, Thomas

“…Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalysed by drug metabolizing enzymes. Prediction of…”
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Oncogene overexpression in non-small-cell lung cancer tissue: prevalence and clinicopathological significance by Lorenz, J, Friedberg, T, Paulus, R, Oesch, F, Ferlinz, R

“…In contrast to small-cell lung cancer, few data are available on the role of oncogene overexpression in non-small-cell lung cancers (NSCLC). To determine the…”
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Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing by Dogra, S, Doehmer, J, Glatt, H, Mölders, H, Siegert, P, Friedberg, T, Seidel, A, Oesch, F

“…V79 Chinese hamster cells genetically engineered to express cytochrome P-450IA1 are reported. A full length cDNA encoding rat cytochrome P-450IA1 was obtained…”
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Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver by Buchmann, A, Kuhlmann, W, Schwarz, M, Kunz, W, Wolf, C R, Moll, E, Friedberg, T, Oesch, F

“…Nitrosamine-induced hepatocarcinogenesis has been used to investigate the regulation and expression of different drug-metabolizing enzymes in preneoplastic and…”
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Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver by Steinberg, P, Lafranconi, W M, Wolf, C R, Waxman, D J, Oesch, F, Friedberg, T

“…To characterize the distribution and inducibility of drug metabolizing enzymes within different hepatic cell populations, the activities of aminopyrine…”
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An amperometric biosensor with human CYP3A4 as a novel drug screening tool by Joseph, Shiba, Rusling, James F., Lvov, Yuri M., Friedberg, Thomas, Fuhr, Uwe

“…We developed a biosensor based on the redox properties of human CYP3A4 to directly monitor electron transfer to the heme protein. Enzyme films were assembled…”
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Human cytochrome P-450 PB-I: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10 by MEEHAN, R. R, GOSDEN, J. R, SWEENEY, J, WOLF, C. R, ROUT, D, HASTIE, N. D, FRIEDBERG, T, ADESNIK, M, BUCKLAND, R, VAN HEYNINGEN, V, FLETCHER, J, SPURR, N. K

“…In the present paper the authors report the isolation and sequence of a cDNA clone for the human hepatic cytochrome P-450 responsible for mephenytoin (an…”
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Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase by Wolf, C R, Moll, E, Friedberg, T, Oesch, F, Buchmann, A, Kuhlmann, W D, Kunz, H W

“…Two cytochromes P450 (PB1 and PB2) have been isolated from the livers of rats treated with phenobarbital. PB2 (mol. wt. 53 500) is novel and is the first…”
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