Search Results - "Fried, Linda P"

Frailty: implications for clinical practice and public health by Hoogendijk, Emiel O, Afilalo, Jonathan, Ensrud, Kristine E, Kowal, Paul, Onder, Graziano, Fried, Linda P

“…Frailty is an emerging global health burden, with major implications for clinical practice and public health. The prevalence of frailty is expected to rise…”
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The physical frailty syndrome as a transition from homeostatic symphony to cacophony by Fried, Linda P., Cohen, Alan A., Xue, Qian-Li, Walston, Jeremy, Bandeen-Roche, Karen, Varadhan, Ravi

“…Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective…”
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Frailty as a Predictor of Surgical Outcomes in Older Patients by Makary, Martin A., MD, MPH, FACS, Segev, Dorry L., MD, PhD, FACS, Pronovost, Peter J., MD, PhD, Syin, Dora, MD, Bandeen-Roche, Karen, PhD, Patel, Purvi, MD, MPH, Takenaga, Ryan, MD, Devgan, Lara, MD, MPH, Holzmueller, Christine G., BLA, Tian, Jing, MS, Fried, Linda P., MD, MPH

“…Background Preoperative risk assessment is important yet inexact in older patients because physiologic reserves are difficult to measure. Frailty is thought to…”
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Inflammation and Frailty in Older Women by Leng, Sean X., Xue, Qian-Li, Tian, Jing, Walston, Jeremy D., Fried, Linda P.

“…OBJECTIVES: To evaluate relationships between white blood cell (WBC) count and interleukin‐6 (IL‐6) and prevalent frailty. DESIGN: Cross‐sectional study…”
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Initial Manifestations of Frailty Criteria and the Development of Frailty Phenotype in the Women's Health and Aging Study II by Xue, Qian-Li, Bandeen-Roche, Karen, Varadhan, Ravi, Zhou, Jing, Fried, Linda P.

“…Background. Understanding points of onset of the frailty syndrome is vital to early identification of at-risk individuals and to targeting intervention efforts…”
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Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults by Walston, Jeremy, Hadley, Evan C., Ferrucci, Luigi, Guralnik, Jack M., Newman, Anne B., Studenski, Stephanie A., Ershler, William B., Harris, Tamara, Fried, Linda P.

“…Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in…”
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Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: Results from the Women's Health and Aging Study (WHAS) II by Frisoli, Alberto, Chaves, Paulo Henrique, Ingham, Sheila Jean McNeill, Fried, Linda P

“…Abstract Objectives The goal of this study was to examine the associations between severe osteopenia and osteoporosis and/or sarcopenia on frailty status, a…”
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The Need to Invest in a Public Health System for Older Adults and Longer Lives, Fit for the Next Pandemic by Fried, Linda P

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Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study I by Semba, Richard D, Patel, Kushang V, Ferrucci, Luigi, Sun, Kai, Roy, Cindy N, Guralnik, Jack M, Fried, Linda P

“…Summary Background & aims Red cell distribution width (RDW), a measure of heterogeneity in the size of circulating erythrocytes, is associated with some…”
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The Baltimore Experience Corps Trial: Enhancing Generativity via Intergenerational Activity Engagement in Later Life by Gruenewald, Tara L, Tanner, Elizabeth K, Fried, Linda P, Carlson, Michelle C, Xue, Qian-Li, Parisi, Jeanine M, Rebok, George W, Yarnell, Lisa M, Seeman, Teresa E

“…Being and feeling generative, defined as exhibiting concern and behavior to benefit others, is an important developmental goal of midlife and beyond. Although…”
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Declines and Impairment in Executive Function Predict Onset of Physical Frailty by Gross, Alden L, Xue, Qian-Li, Bandeen-Roche, Karen, Fried, Linda P, Varadhan, Ravi, McAdams-DeMarco, Mara A, Walston, Jeremy, Carlson, Michelle C

“…Clinical cognitive impairment and physical frailty often co-occur. However, it is unclear whether preclinical impairment or decline in cognitive domains are…”
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Detection of a novel, integrative aging process suggests complex physiological integration by Cohen, Alan A, Milot, Emmanuel, Li, Qing, Bergeron, Patrick, Poirier, Roxane, Dusseault-Bélanger, Francis, Fülöp, Tamàs, Leroux, Maxime, Legault, Véronique, Metter, E Jeffrey, Fried, Linda P, Ferrucci, Luigi

“…Many studies of aging examine biomarkers one at a time, but complex systems theory and network theory suggest that interpretations of individual markers may be…”
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Hyperglycemia and Incidence of Frailty and Lower Extremity Mobility Limitations in Older Women by Kalyani, Rita R., Tian, Jing, Xue, Qian-Li, Walston, Jeremy, Cappola, Anne R., Fried, Linda P., Brancati, Frederick L., Blaum, Caroline S.

“…Objectives To determine the degree to which hyperglycemia predicts the development of frailty and lower extremity mobility limitations. Design Secondary data…”
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Identifying pathways to increased volunteering in older US adults by Nakamura, Julia S., Lee, Matthew T., Chen, Frances S., Archer Lee, Yeeun, Fried, Linda P., VanderWeele, Tyler J., Kim, Eric S.

“…While growing evidence documents strong associations between volunteering and improved health and well-being outcomes, less is known about the health and…”
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Examining the dynamic, bidirectional associations between cognitive and physical functioning in older adults by Krall, Jenna R, Carlson, Michelle C, Fried, Linda P, Xue, Qian-Li

“…The delineation of the interrelationships between cognitive and physical functioning in older adults is critical to determining pathways to disability. By…”
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Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition by Cohen, Alan A, Li, Qing, Milot, Emmanuel, Leroux, Maxime, Faucher, Samuel, Morissette-Thomas, Vincent, Legault, Véronique, Fried, Linda P, Ferrucci, Luigi

“…Physiological dysregulation may underlie aging and many chronic diseases, but is challenging to quantify because of the complexity of the underlying systems…”
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Dysphagia in Old-Old Women: Prevalence as Determined According to Self-Report and the 3-Ounce Water Swallowing Test by González-Fernández, Marlís, Humbert, Ianessa, Winegrad, Heather, Cappola, Anne R., Fried, Linda P.

“…Objectives To determine whether symptoms and clinical signs of swallowing dysfunction could be easily identified in community‐dwelling elderly adults and to…”
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Exploring the Effects of an “Everyday” Activity Program on Executive Function and Memory in Older Adults: Experience Corps by Carlson, Michelle C., Saczynski, Jane S., Rebok, George W., Seeman, Teresa, Glass, Thomas A., McGill, Sylvia, Tielsch, James, Frick, Kevin D., Hill, Joel, Fried, Linda P.

“…Purpose: There is little empirical translation of multimodal cognitive activity programs in “real-world” community-based settings. This study sought to…”
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Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report by Ferrucci, Luigi, Guralnik, Jack M., Studenski, Stephanie, Fried, Linda P., Cutler Jr, Gordon B., Walston, Jeremy D.

“…The discovery of effective interventions to prevent or delay disability in older persons is a public health priority. Most likely to benefit from such…”
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Functional Decline and Recovery of Activities of Daily Living in Hospitalized, Disabled Older Women: The Women's Health and Aging Study I by Boyd, Cynthia M., Ricks, Michelle, Fried, Linda P., Guralnik, Jack M., Xue, Qian-Li, Xia, Jin, Bandeen-Roche, Karen

“…OBJECTIVES: To determine, in disabled, older, community‐dwelling women who were hospitalized, the rates and predictors of functional decline, the probability…”
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