Search Results - "Fridolfsson, Heidi"

Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges by Starr, Daniel A, Fridolfsson, Heidi N

“…The nuclear envelope links the cytoskeleton to structural components of the nucleus. It functions to coordinate nuclear migration and anchorage, organize…”
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Regulation of intracellular signaling and function by caveolin by Fridolfsson, Heidi N., Roth, David M., Insel, Paul A., Patel, Hemal H.

“…Caveolae, flask‐like invaginations of the plasma membrane, were discovered nearly 60 years ago. Originally regarded as fixation artifacts of electron…”
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Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei by Fridolfsson, Heidi N, Starr, Daniel A

“…Kinesin-1 and dynein are recruited to the nuclear envelope by the Caenorhabditis elegans klarsicht/ANC-1/Syne homology (KASH) protein UNC-83 to move nuclei…”
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A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue by Green, Rebecca A., Kao, Huey-Ling, Audhya, Anjon, Arur, Swathi, Mayers, Jonathan R., Fridolfsson, Heidi N., Schulman, Monty, Schloissnig, Siegfried, Niessen, Sherry, Laband, Kimberley, Wang, Shaohe, Starr, Daniel A., Hyman, Anthony A., Schedl, Tim, Desai, Arshad, Piano, Fabio, Gunsalus, Kristin C., Oegema, Karen

“…High-content screening for gene profiling has generally been limited to single cells. Here, we explore an alternative approach—profiling gene function by…”
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Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization by Morgan, Joshua T, Pfeiffer, Emily R, Thirkill, Twanda L, Kumar, Priyadarsini, Peng, Gordon, Fridolfsson, Heidi N, Douglas, Gordon C, Starr, Daniel A, Barakat, Abdul I

“…Changes in blood flow regulate gene expression and protein synthesis in vascular endothelial cells, and this regulation is involved in the development of…”
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UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration by Meyerzon, Marina, Fridolfsson, Heidi N, Ly, Nina, McNally, Francis J, Starr, Daniel A

“…Intracellular nuclear migration is essential for many cellular events including fertilization, establishment of polarity, division and differentiation. How…”
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Mitochondria‐localized caveolin in adaptation to cellular stress and injury by Fridolfsson, Heidi N., Kawaraguchi, Yoshitaka, Ali, Sameh S., Panneerselvam, Mathivadhani, Niesman, Ingrid R., Finley, J. Cameron, Kellerhals, Sarah E., Migita, Michael Y., Okada, Hideshi, Moreno, Ana L., Jennings, Michelle, Kidd, Michael W., Bonds, Jacqueline A., Balijepalli, Ravi C., Ross, Robert S., Patel, Piyush M., Miyanohara, Atsushi, Chen, Qun, Lesnefsky, Edward J., Head, Brian P., Roth, David M., Insel, Paul A., Patel, Hemal H.

“…We show here that the apposition of plasma membrane caveolae and mitochondria (first noted in electron micrographs >50 yr ago) and caveolae‐mitochondria…”
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High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression by White, Amanda T, Philp, Andrew, Fridolfsson, Heidi N, Schilling, Jan M, Murphy, Anne N, Hamilton, D Lee, McCurdy, Carrie E, Patel, Hemal H, Schenk, Simon

“…Skeletal muscle sirtuin 1 (SIRT1) expression is reduced under insulin-resistant conditions, such as those resulting from high-fat diet (HFD) feeding and…”
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UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration by Fridolfsson, Heidi N., Ly, Nina, Meyerzon, Marina, Starr, Daniel A.

“…Nuclei migrate during many events, including fertilization, establishment of polarity, differentiation, and cell division. The Caenorhabditis elegans KASH…”
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Caveolin and caveolae in age associated cardiovascular disease by Fridolfsson, Heidi N, Patel, Hemal H

“…It is estimated that the elderly (> 65 years of age) will increase from 13%-14% to 25% by 2035. If this trend continues, > 50% of the United States population…”
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Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia by Niesman, Ingrid R., Zemke, Nathan, Fridolfsson, Heidi N., Haushalter, Kristofer J., Levy, Karen, Grove, Anna, Schnoor, Rosalie, Finley, J. Cameron, Patel, Piyush M., Roth, David M., Head, Brian P., Patel, Hemal H.

“…Microglia are ramified cells that serve as central nervous system (CNS) guardians, capable of proliferation, migration, and generation of inflammatory…”
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kinase interacting protein (AKIP1) is a key regulator of cardiac stress by Sastri, Mira, Haushalter, Kristofer J, Panneerselvam, Mathivadhani, Chang, Philip, Fridolfsson, Heidi, Finley, J Cameron, Ng, Daniel, Schilling, Jan M, Miyanohara, Atsushi, Day, Michele E, Hakozaki, Hiro, Petrosyan, Susanna, Koller, Antonius, King, Charles C, Darshi, Manjula, Blumenthal, Donald K, Ali, Sameh Saad, Roth, David M, Patel, Hemal H, Taylor, Susan S

“…Significance Early signaling events leading to protection in the heart under cardiac injury are poorly understood. We identified one such protein, A kinase…”
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A new sense of protection: role of the Ca2+-sensing receptor in ischemic preconditioning by Busija, Anna R, Fridolfsson, Heidi N, Patel, Hemal H

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Caveolin‐2: Improves Longevity and Allows for Stress Adaptation in C. Elegans by Mehta, Meghna D., Schilling, Jan M., Mehta, Ekta D., Fridolfsson, Heidi N., Roth, David M., Patel, Hemal H.

“…Abstract only…”
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Caveolin‐2 Enhances Longevity and Induces Stress Adaptation In C. elegans by Mehta, Meghna D., Mehta, Ekta D., Schilling, Jan M., Shi, Eileen, Fridolfsson, Heidi N., Roth, David M., Patel, Hemal H.

“…Abstract only Caveolae are plasma membrane invaginations common to many cells. Caveolae are enriched in proteins such as caveolin, which are structural…”
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Generation of caveolin‐2 overexpressing C. elegans and their response to stress by Shi, Eileen, Fridolfsson, Heidi N., Kwan, Evan, Schilling, Jan M., Patel, Hemal H.

“…Abstract only The plasma membrane is a key barrier that impedes external stressors and responds to them by utilizing signaling microenvironments. Lipids rafts…”
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Novel roles of chromogranin A and its peptide, catestatin, in cardioprotection (652.3) by Schilling, Jan, Avolio, Ennio, Zemljic‐Harpf, Alice, Headrick, John, Fridolfsson, Heidi, Kassan, Adam, Bandyopadhyay, Gautam, Siddiqui, Jawed, O'Connor, Daniel, Roth, David, Patel, Hemal, Mahata, Sushil

“…Chromogranin A (Chga) is abundant in (neuro) endocrine cells, and its derived peptide catestatin (CST) acts as an antihypertensive, cardioprotective,…”
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AKIP1 regulation of PKA and NF‐κB in the heart by Sastri, Mira, Chang, Philip, Fridolfsson, Heidi, Paneerselvam, Mathivadhani, Ng, Daniel, Taylor, Susan, Patel, Hemal

“…Abstract only Ischemic preconditioning, an endogenous protective mechanism to salvage ischemic myocardium, was described nearly 25 years ago; however, there…”
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Myocardial cholesterol homeostasis is altered by age and Cav‐3 knockdown by Schilling, Jan Mirko, Fridolfsson, Heidi N, Panneerselvam, Mathivadhani, Finley, Joseph C, Kellerhals, Sarah E, Niesman, Ingrid, Head, Brian P, Roth, David M, Patel, Hemal H

“…Abstract only Cardiovascular disease (CVD) is a leading cause of mortality in the United States. The percentage of people over the age of 65 years is…”
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Therapeutic Role of Caveolin‐3 in Mitochondrial Directed Cardioprotection during the Development of Diabetic Cardiomyopathy by Migita, Michael Yoshimichi, Zemljic‐Harpf, Alice E., Finley, J. Cameron, Kellerhals, Sarah E., Fridolfsson, Heidi N., Panneerselvam, Mathivadhani, Niesman, Ingrid R., Ali, Sameh S., Roth, David M., Patel, Hemal H.

“…Abstract only Diabetes is a worldwide epidemic with cardiovascular disease being a major complication. Caveolins act as scaffolding molecules for regulating…”
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