Search Results - "Fridman, Micha"

Cationic Pillararenes Potently Inhibit Biofilm Formation without Affecting Bacterial Growth and Viability by Joseph, Roymon, Naugolny, Alissa, Feldman, Mark, Herzog, Ido M, Fridman, Micha, Cohen, Yoram

“…It is estimated that up to 80% of bacterial infections are accompanied by biofilm formation. Since bacteria in biofilms are less susceptible to antibiotics…”
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Guiding Drugs to Target‐Harboring Organelles: Stretching Drug‐Delivery to a Higher Level of Resolution by Louzoun‐Zada, Sivan, Jaber, Qais Z., Fridman, Micha

“…The ratio between the dose of drug required for optimal efficacy and the dose that causes toxicity is referred to as the therapeutic window. This ratio can be…”
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Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase by Logviniuk, Dana, Jaber, Qais Z, Dobrovetsky, Roman, Kozer, Noga, Ksiezopolska, Ewa, Gabaldón, Toni, Carmeli, Shmuel, Fridman, Micha

“…Each year, infections caused by fungal pathogens claim the lives of about 1.6 million people and affect the health of over a billion people worldwide. Among…”
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Di-N-Methylation of Anti-Gram-Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram-Negative Bacteria by Benhamou, Raphael I., Shaul, Pazit, Herzog, Ido M., Fridman, Micha

“…The effect of di‐N‐methylation of bacterial membrane disruptors derived from aminoglycosides (AGs) on antimicrobial activity is reported. Di‐N‐methylation of…”
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Tuning the Effects of Bacterial Membrane Permeability through Photo‐Isomerization of Antimicrobial Cationic Amphiphiles by Salta, Joana, Benhamou, Raphael I., Herzog, Ido M., Fridman, Micha

“…Several important antimicrobial drugs act by permeabilizing cell membranes. In this study, we showed that the intensity of membrane permeability caused by…”
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Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells by Benhamou, Raphael I, Jaber, Qais Z, Herzog, Ido M, Roichman, Yael, Fridman, Micha

“…In fungal cells, the endoplasmic reticulum (ER) harbors several of the enzymes involved in the biosynthesis of ergosterol, an essential membrane component,…”
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Chiral Fluorescent Antifungal Azole Probes Detect Resistance, Uptake Dynamics, and Subcellular Distribution in Candida Species by Koren, Vlad, Ben-Zeev, Efrat, Voronov, Ivan, Fridman, Micha

“…Azoles are essential for fungal infection treatment, yet the increasing resistance highlights the need for innovative diagnostic tools and strategies to…”
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Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells by Benhamou, Raphael I, Bibi, Maayan, Steinbuch, Kfir B, Engel, Hamutal, Levin, Maayan, Roichman, Yael, Berman, Judith, Fridman, Micha

“…Azoles are the most commonly used class of antifungal drugs, yet where they localize within fungal cells and how they are imported remain poorly understood…”
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Site-Selective Displacement of Tobramycin Hydroxyls for Preparation of Antimicrobial Cationic Amphiphiles by Berkov-Zrihen, Yifat, Herzog, Ido M, Feldman, Mark, Fridman, Micha

“…A short site-selective strategy for the activation and derivatization of alcohols of the clinically important aminoglycoside tobramycin is reported. The choice…”
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Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays by Tannous, Rozan, Shelef, Omri, Gutkin, Sara, David, Maya, Leirikh, Thomas, Ge, Liang, Jaber, Qais, Zhou, Qingyang, Ma, Pengchen, Fridman, Micha, Spitz, Urs, Houk, Kendall N., Shabat, Doron

“…Chemiluminescence is a fascinating phenomenon that involves the generation of light through chemical reactions. The light emission from…”
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One-Pot Chemoenzymatic Cascade for Labeling of the Epigenetic Marker 5-Hydroxymethylcytosine by Nifker, Gil, Levy-Sakin, Michal, Berkov-Zrihen, Yifat, Shahal, Tamar, Gabrieli, Tslil, Fridman, Micha, Ebenstein, Yuval

“…The epigenetic DNA modification 5‐hydroxymethylcytosine (5‐hmC) is important for the regulation of gene expression during development and in tumorigenesis…”
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Boosting Chemiexcitation of Phenoxy-1,2-dioxetanes through 7‑Norbornyl and Homocubanyl Spirofusion by Gutkin, Sara, Shelef, Omri, Babjaková, Zuzana, Tomanová, Laura Anna, Babjak, Matej, Kopp, Tal, Zhou, Qingyang, Ma, Pengchen, Fridman, Micha, Spitz, Urs, Houk, Kendall N., Shabat, Doron

“…The chemiluminescent light-emission pathway of phenoxy-1,2-dioxetane luminophores is increasingly attracting the scientific community’s attention. Dioxetane…”
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Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast by Jaber, Qais Z, Bibi, Maayan, Ksiezopolska, Ewa, Gabaldon, Toni, Berman, Judith, Fridman, Micha

“…Echinocandins are the newest class of antifungal drugs in clinical use. These agents inhibit β-glucan synthase, which catalyzes the synthesis of β-glucan, an…”
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Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides by Green, Keith D, Chen, Wenjing, Houghton, Jacob L, Fridman, Micha, Garneau-Tsodikova, Sylvie

“…Aminoglycosides are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. Decades of clinical use have led to the…”
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Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG by Gajadeera, Chathurada, Willby, Melisa J, Green, Keith D, Shaul, Pazit, Fridman, Micha, Garneau-Tsodikova, Sylvie, Posey, James E, Tsodikov, Oleg V

“…Owing to the rise in drug resistance in tuberculosis combined with the global spread of its causative pathogen, Mycobacterium tuberculosis ( Mtb ), innovative…”
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Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell Wall Chitin Production, but Its Antifungal Activity Is Hindered by This Polysaccharide and by Fungal Essential Metals by Yona, Adi, Fridman, Micha

“…Climate and environmental changes have modified the habitats of fungal pathogens, inflicting devastating effects on livestock and crop production…”
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Deciphering the Biological Activities of Antifungal Agents with Chemical Probes by Fridman, Micha, Sakurai, Kaori

“…The growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these…”
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Characterization of Rhodosaminyl Transfer by the AknS/AknT Glycosylation Complex and Its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A by Leimkuhler, Catherine, Fridman, Micha, Lupoli, Tania, Walker, Suzanne, Walsh, Christopher T, Kahne, Daniel

“…The tetracyclic core of anthracycline natural products with antitumor activity such as aclacinomycin A are tailored during biosynthesis by regioselective…”
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The relationship between the structure and toxicity of aminoglycoside antibiotics by Jospe-Kaufman, Moriah, Siomin, Liza, Fridman, Micha

“…[Display omitted] Aminoglycoside antibiotics, used to treat persistent gram-negative infections, tuberculosis, and life-threatening infections in neonates and…”
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One-Pot Synthesis of Glucosamine Oligosaccharides by Fridman, Micha, Solomon, Dmitry, Yogev, Shay, Baasov, Timor

“…Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and…”
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