Search Results - "Fricker, Lloyd D"

Proteasome Inhibitor Drugs by Fricker, Lloyd D

“…Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into peptides. There are many distinct forms of proteasomes that differ…”
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Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins by Fricker, Lloyd D

“…Peptides are known to play many important physiological roles in signaling. A large number of peptides have been detected in mouse brain extracts using mass…”
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Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells by Dasgupta, Sayani, Castro, Leandro M, Dulman, Russell, Yang, Ciyu, Schmidt, Marion, Ferro, Emer S, Fricker, Lloyd D

“…The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with…”
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Multiple Isotopic Labels for Quantitative Mass Spectrometry by Morano, Cain, Zhang, Xin, Fricker, Lloyd D

“…Quantitative mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammoniumbutyryl (TMAB) labels have many…”
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Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomib by Gelman, Julia S, Sironi, Juan, Berezniuk, Iryna, Dasgupta, Sayani, Castro, Leandro M, Gozzo, Fabio C, Ferro, Emer S, Fricker, Lloyd D

“…Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is…”
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Analysis of the Yeast Peptidome and Comparison with the Human Peptidome by Dasgupta, Sayani, Yang, Ciyu, Castro, Leandro M, Tashima, Alexandre K, Ferro, Emer S, Moir, Robyn D, Willis, Ian M, Fricker, Lloyd D

“…Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively…”
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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding by Gomes, Ivone, Aryal, Dipendra K., Wardman, Jonathan H., Gupta, Achla, Gagnidze, Khatuna, Rodriguiz, Ramona M., Kumar, Sanjai, Wetsel, William C., Pintar, John E., Fricker, Lloyd D., Devi, Lakshmi A.

“…Multiple peptide systems, including neuropeptide Y, leptin, ghrelin, and others, are involved with the control of food intake and body weight. The peptide…”
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ProSAAS-derived peptides are differentially processed and sorted in mouse brain and AtT-20 cells by Wardman, Jonathan H, Fricker, Lloyd D

“…ProSAAS is the precursor for some of the most abundant peptides found in mouse brain and other tissues, including peptides named SAAS, PEN, and LEN. Both SAAS…”
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Substrate Specificity and Structural Modeling of Human Carboxypeptidase Z: A Unique Protease with a Frizzled-Like Domain by Garcia-Pardo, Javier, Tanco, Sebastian, Garcia-Guerrero, Maria C, Dasgupta, Sayani, Avilés, Francesc Xavier, Lorenzo, Julia, Fricker, Lloyd D

“…Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of…”
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Zebrafish Cytosolic Carboxypeptidases 1 and 5 Are Essential for Embryonic Development by Lyons, Peter J., Sapio, Matthew R., Fricker, Lloyd D.

“…The cytosolic carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 family of carboxypeptidases that have been implicated in the…”
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Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease by Dasgupta, Sayani, Fishman, Michael A, Mahallati, Hana, Castro, Leandro M, Tashima, Alexandre K, Ferro, Emer S, Fricker, Lloyd D

“…Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular…”
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Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy by Sapio, Matthew R, Vessaz, Monique, Thomas, Pierre, Genton, Pierre, Fricker, Lloyd D, Salzmann, Annick

“…Carboxypeptidase A6 (CPA6) is a peptidase that removes C-terminal hydrophobic amino acids from peptides and proteins. The CPA6 gene is expressed in the brains…”
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Characterization of the Substrate Specificity of Human Carboxypeptidase A4 and Implications for a Role in Extracellular Peptide Processing by Tanco, Sebastian, Zhang, Xin, Morano, Cain, Avilés, Francesc Xavier, Lorenzo, Julia, Fricker, Lloyd D.

“…CPA4 (carboxypeptidase A4) is a member of the metallocarboxypeptidase family. CPA4 was originally found in a screen of mRNAs up-regulated by sodium…”
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Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules by Lopes, Mark William, Sapio, Matthew R, Leal, Rodrigo B, Fricker, Lloyd D

“…Carboxypeptidase A6 (CPA6) is an extracellular matrix metallocarboxypeptidase that modulates peptide and protein function by removal of hydrophobic C-terminal…”
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Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains by Garcia-Pardo, Javier, Tanco, Sebastian, Díaz, Lucía, Dasgupta, Sayani, Fernandez-Recio, Juan, Lorenzo, Julia, Aviles, Francesc X, Fricker, Lloyd D

“…Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic…”
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Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides by Fricker, Lloyd D, Gelman, Julia S, Castro, Leandro M, Gozzo, Fabio C, Ferro, Emer S

“…Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts of animal tissues and cell lines. To test whether the…”
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Quantitative Peptidomics: General Considerations by Fricker, Lloyd D

“…Peptidomics is the detection and identification of the peptides present in a sample, and quantitative peptidomics provides additional information about the…”
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Neuropeptidomics of Genetically Defined Cell Types in Mouse Brain by Fricker, Lloyd D

“…Peptidomic techniques are powerful tools to identify peptides in a biological sample. In the case of brain, which contains a complex mixture of cell types,…”
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Peptidomics: Identification and quantification of endogenous peptides in neuroendocrine tissues by Fricker, Lloyd D., Lim, Jihyeon, Pan, Hui, Che, Fa-Yun

“…Neuropeptides perform a large variety of functions as intercellular signaling molecules. While most proteomic studies involve digestion of the proteins with…”
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Quantitative peptidomics of mice lacking peptide-processing enzymes by Wardman, Jonathan, Fricker, Lloyd D

“…Peptidomics is defined as the analysis of peptides present in a tissue extract, usually using mass spectrometry-based approaches. Unlike radioimmunoassay-based…”
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