Search Results - "Frias, Rosa"

Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer by Recondo, Gonzalo, Mezquita, Laura, Facchinetti, Francesco, Planchard, David, Gazzah, Anas, Bigot, Ludovic, Rizvi, Ahsan Z, Frias, Rosa L, Thiery, Jean Paul, Scoazec, Jean-Yves, Sourisseau, Tony, Howarth, Karen, Deas, Olivier, Samofalova, Dariia, Galissant, Justine, Tesson, Pauline, Braye, Floriane, Naltet, Charles, Lavaud, Pernelle, Mahjoubi, Linda, Abou Lovergne, Aurélie, Vassal, Gilles, Bahleda, Rastilav, Hollebecque, Antoine, Nicotra, Claudio, Ngo-Camus, Maud, Michiels, Stefan, Lacroix, Ludovic, Richon, Catherine, Auger, Nathalie, De Baere, Thierry, Tselikas, Lambros, Solary, Eric, Angevin, Eric, Eggermont, Alexander M, Andre, Fabrice, Massard, Christophe, Olaussen, Ken A, Soria, Jean-Charles, Besse, Benjamin, Friboulet, Luc

“…Lorlatinib is a third-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor with proven efficacy in patients with ALK-rearranged lung cancer…”
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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models by Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

“…We report the preclinical evaluation of PF-06463922, a potent and brain-penetrant ALK/ROS1 inhibitor. Compared with other clinically available ALK inhibitors,…”
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Patient-derived models of acquired resistance can identify effective drug combinations for cancer by Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.

“…Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic…”
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Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F by Shaw, Alice T, Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F, Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J, Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L, Schultz, Kate R, Logan, Jennifer, James, Leonard P, Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W, Engelman, Jeffrey A

“…A resistance mutation (C1156Y) developed in a woman with anaplastic lymphoma kinase ( ALK )-rearranged lung cancer who had a response to crizotinib. She then…”
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Temporal susceptibility of almond pruning wounds to infection by fungal canker pathogens in California by Holland, Leslie A., Travadon, Renaud, Lawrence, Daniel P., Jaime‐Frias, Rosa, Nouri, Mohamed T., Sahtout, Mohammad, Trouillas, Florent P.

“…Numerous fungal canker pathogens threaten almond production in California, causing high tree mortality and reducing orchard longevity. Pruning wounds are the…”
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Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC by Alessi, Joao V, Elkrief, Arielle, Ricciuti, Biagio, Wang, Xinan, Cortellini, Alessio, Vaz, Victor R, Lamberti, Giuseppe, Frias, Rosa L, Venkatraman, Deepti, Fulgenzi, Claudia A M, Pecci, Federica, Recondo, Gonzalo, Di Federico, Alessandro, Barrichello, Adriana, Park, Hyesun, Nishino, Mizuki, Hambelton, Grace M, Egger, Jacklynn V, Ladanyi, Marc, Digumarthy, Subba, Johnson, Bruce E, Christiani, David C, Lin, Xihong, Gainor, Justin F, Lin, Jessica J, Pinato, David J, Schoenfeld, Adam J, Awad, Mark M

“…Although programmed cell death protein 1 and programmed death-ligand 1 (PD-L1) blockade in combination with platinum-doublet chemotherapy has become a mainstay…”
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Phylogenomic analyses and comparative genomics of Pseudomonas syringae associated with almond (Prunus dulcis) in California by Maguvu, Tawanda E, Frias, Rosa J, Hernandez-Rosas, Alejandro I, Holtz, Brent A, Niederholzer, Franz J A, Duncan, Roger A, Yaghmour, Mohammad A, Culumber, Catherine M, Gordon, Phoebe E, Vieira, Flavia C F, Rolshausen, Philippe E, Adaskaveg, James E, Burbank, Lindsey P, Lindow, Steven E, Trouillas, Florent P

“…We sequenced and comprehensively analysed the genomic architecture of 98 fluorescent pseudomonads isolated from different symptomatic and asymptomatic tissues…”
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Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer by Varkaris, Andreas, Katsiampoura, Anastasia, Davis, Jennifer S., Shah, Neeraj, Lam, Michael, Frias, Rosa Lizeth, Ivan, Cristina, Shimizu, Masayoshi, Morris, Jeffrey, Menter, David, Overman, Michael, Tran, Hai, Heymach, John, Chun, Yun Shin, Vauthey, Jean-Nicolas, Calin, George, Kopetz, Scott

“…Background Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease from a clinical, molecular, and immunological perspective. Current predictive…”
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Pathogenicity, phylogenomic, and comparative genomic study of Pseudomonas syringae sensu lato affecting sweet cherry in California by Maguvu, Tawanda E, Frias, Rosa J, Hernandez-Rosas, Alejandro I, Shipley, Erin, Dardani, Greta, Nouri, Mohamed T, Yaghmour, Mohammad A, Trouillas, Florent P

“…To gain insights into the diversity of sensu lato affecting sweet cherry in California, we sequenced and analyzed the phylogenomic and genomic architecture of…”
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Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy by Recondo, Gonzalo, Mahjoubi, Linda, Maillard, Aline, Loriot, Yohann, Bigot, Ludovic, Facchinetti, Francesco, Bahleda, Rastislav, Gazzah, Anas, Hollebecque, Antoine, Mezquita, Laura, Planchard, David, Naltet, Charles, Lavaud, Pernelle, Lacroix, Ludovic, Richon, Catherine, Lovergne, Aurelie Abou, De Baere, Thierry, Tselikas, Lambros, Deas, Olivier, Nicotra, Claudio, Ngo-Camus, Maud, Frias, Rosa L., Solary, Eric, Angevin, Eric, Eggermont, Alexander, Olaussen, Ken A., Vassal, Gilles, Michiels, Stefan, Andre, Fabrice, Scoazec, Jean-Yves, Massard, Christophe, Soria, Jean-Charles, Besse, Benjamin, Friboulet, Luc

“…Unravelling the biological processes driving tumour resistance is necessary to support the development of innovative treatment strategies. We report the design…”
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Defining cellular responses to HDAC-selective inhibitors reveals that efficient targeting of HDAC3 is required to elicit cytotoxicity and overcome naïve resistance to pan-HDACi in diffuse large B cell lymphoma by Havas, Aaron P., Tula-Sanchez, Ana A., Steenhoek, Hailey M., Bhakta, Anvi, Wingfield, Taylor, Huntley, Matthew J., Nofal, Angela S., Ahmed, Tasmia, Jaime-Frias, Rosa, Smith, Catharine L.

“…•Mechanisms of naïve resistance to pan-HDACi in DLBCL cell lines are undefined.•Selective inhibition of HDACs 1 and 2 underlies the pan-HDACi resistant…”
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Descriptive analysis of hospital activity indicators published by the Autonomous Regional Governments in the Spanish National Health System. by García-Vicente, Sergio, de Ramón-Frías, Rosa, Máñez-Ortiz, Miguel Ángel

“…The supply of health activity data by health regional governments does not have a current study of the issue. The aim of this study was to analyze and describe…”
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Epidemiologic and socioeconomic characteristics of Hispanics diagnosed with metastatic renal cell carcinoma in the US by Murray, Abner, Ocejo Gallegos, Jesus Antonio, Jones, Sandra, Frias, Rosa Lizeth, Noy, Jose, Campoverde, Leticia, Merchan, Jaime R.

“…e16555 Background: Annually, there are over 400,000 new renal cell carcinoma (RCC) cases and more than 170,000 deaths worldwide. In the US, 80,000 new cases of…”
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Clinical-pathological features and treatment outcomes in Hispanic/Latino patients with advanced renal cell carcinoma at a single institution by Ocejo Gallegos, Jesus Antonio, Murray, Abner, Jones, Sandra, Frias, Rosa Lizeth, Noy, Jose, Campoverde, Leticia, Merchan, Jaime R.

“…e16554 Background: Annually, there are over 400,000 new renal cell carcinoma (RCC) cases and more than 170,000 deaths worldwide. RCC is one of the top ten more…”
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A comparative study of six European databases of medically oriented Web resources by ABAD GARCIA, Francisca, GONZALEZ TERUE, Aurora, BAYO CALDUCH, Patricia, DE RAMON FRIAS, Rosa, CASTILLO BLASCO, Lourdes

“…The paper describes six European medically oriented databases of Web resources, pertaining to five quality-controlled subject gateways, and compares their…”
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Phylogenomic analyses and comparative genomics of Pseudomonas syringae associated with almond by Maguvu, Tawanda E, Frias, Rosa J, Hernandez-Rosas, Alejandro I, Holtz, Brent A, Niederholzer, Franz J. A, Duncan, Roger A, Yaghmour, Mohammad A, Culumber, Catherine M, Gordon, Phoebe E, Vieira, Flavia C. F, Rolshausen, Philippe E, Adaskaveg, James E, Burbank, Lindsey P, Lindow, Steven E, Trouillas, Florent P

“…We sequenced and comprehensively analysed the genomic architecture of 98 fluorescent pseudomonads isolated from different symptomatic and asymptomatic tissues…”
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Development of PCR-based Assays for Rapid and Reliable Detection and Identification of Canker-causing Pathogens from Symptomatic Almond Trees by Avenot, Herve Fabrice, Jaime-Frias, Rosa, Travadon, Renaud, Holland, Leslie, Lawrence, Daniel P, Trouillas, Florent

“…Trunk and scaffold canker diseases (TSCD) of almond cause significant yield and tree losses and reduce the lifespan of orchards. In California, several…”
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Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors by Griggs, Chanel A., Malm, Scott W., Jaime-Frias, Rosa, Smith, Catharine L.

“…Valproic acid (VPA) is a well-established therapeutic used in treatment of seizure and mood disorders as well as migraines and a known hepatotoxicant. About…”
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Análisis descriptivo de los indicadores de actividad hospitalaria publicados por las consejerías de salud by Máñez Ortiz, Miguel Ángel, García Vicente, S, Ramón Frías, Rosa Mª de

“…Background: The supply of health activity data by health regional governments does not have a current study of the issue. The aim of this study was to analyze…”
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Abstract 722: Epidemiological characterization of renal cell carcinoma in Hispanics: A single US center cohort study by Murray, Abner A., Gallegos, Jesus A. Ocejo, Jones, Sandra, Noy, Jose, Frias, Rosa L., Campoverde, Leticia E., Merchan, Jaime R.

“…Abstract Background: Annually, there are over 400,000 new cases of renal cell carcinoma (RCC) and more than 170,000 deaths worldwide. RCC is one of the top ten…”
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