Search Results - "Frias, Elma S"

Bioenergetic regulation of microglia by Ghosh, Soumitra, Castillo, Erika, Frias, Elma S., Swanson, Raymond A.

“…Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability…”
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Female mice are protected from space radiation-induced maladaptive responses by Krukowski, Karen, Grue, Katherine, Frias, Elma S., Pietrykowski, John, Jones, Tamako, Nelson, Gregory, Rosi, Susanna

“…•Male mice have long lasting cognitive and behavioral deficits after space radiation exposure.•Microglia activation and synapse loss correspond to behavioral…”
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Small molecule cognitive enhancer reverses age-related memory decline in mice by Krukowski, Karen, Nolan, Amber, Frias, Elma S, Boone, Morgane, Ureta, Gonzalo, Grue, Katherine, Paladini, Maria-Serena, Elizarraras, Edward, Delgado, Luz, Bernales, Sebastian, Walter, Peter, Rosi, Susanna

“…With increased life expectancy, age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease. The…”
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GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii by David, Clément N, Frias, Elma S, Szu, Jenny I, Vieira, Philip A, Hubbard, Jacqueline A, Lovelace, Jonathan, Michael, Marena, Worth, Danielle, McGovern, Kathryn E, Ethell, Iryna M, Stanley, B Glenn, Korzus, Edward, Fiacco, Todd A, Binder, Devin K, Wilson, Emma H

“…The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about the effects of lifelong brain…”
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Combined space stressors induce independent behavioral deficits predicted by early peripheral blood monocytes by Rienecker, Kira D. A., Grue, Katherine, Paladini, Maria Serena, Frias, Elma S., Frattini, Valentina, Borlongan, Mia C., Chou, Austin, Torres-Espin, Abel, Krukowski, Karen, Ferguson, Adam R., Rosi, Susanna

“…Interplanetary space travel poses many hazards to the human body. To protect astronaut health and performance on critical missions, there is first a need to…”
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Functional role of brain-engrafted macrophages against brain injuries by Feng, Xi, Frias, Elma S, Paladini, Maria S, Chen, David, Boosalis, Zoe, Becker, McKenna, Gupta, Sonali, Liu, Sharon, Gupta, Nalin, Rosi, Susanna

“…Brain-resident microglia have a distinct origin compared to macrophages in other organs. Under physiological conditions, microglia are maintained by…”
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The Integrated Stress Response: A Central Memory Switch in Down Syndrome by Rosi, Susanna, Frias, Elma S.

“…Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory…”
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Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury by Krukowski, Karen, Nolan, Amber, Becker, McKenna, Picard, Katherine, Vernoux, Nathalie, Frias, Elma S., Feng, Xi, Tremblay, Marie-Eve, Rosi, Susanna

“…•Spatial learning and memory deficits are measured seven days post injury in male and female mice.•In vivo microglia phagocytic activity was increased after…”
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Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition by Frias, Elma S, Hoseini, Mahmood S, Krukowski, Karen, Paladini, Maria Serena, Grue, Katherine, Ureta, Gonzalo, Rienecker, Kira D A, Walter, Peter, Stryker, Michael P, Rosi, Susanna

“…Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the strongest environmental risk factor for the…”
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The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures by Krukowski, Karen, Grue, Katherine, Becker, McKenna, Elizarraras, Edward, Frias, Elma S, Halvorsen, Aaron, Koenig-Zanoff, McKensie, Frattini, Valentina, Nimmagadda, Hasitha, Feng, Xi, Jones, Tamako, Nelson, Gregory, Ferguson, Adam R, Rosi, Susanna

“…In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major…”
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Antitumor Activity of a Polypyridyl Chelating Ligand: In Vitro and In Vivo Inhibition of Glioma by David, Clément N., Frias, Elma S., Elix, Catherine C., McGovern, Kathryn E., Walker, Ameae M., Eichler, Jack F., Wilson, Emma H.

“…Glioblastoma multiforme is an extremely aggressive and invasive form of central nervous system tumor commonly treated with the chemotherapeutic drug…”
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Small molecule cognitive enhancer reverses age-related memory decline in mice by Krukowski, K., Nolan, Amber, Frias, Elma S., Boone, Morgane, Ureta, Gonzalo, Grue, Katherine, Paladini, Maria-Serena, Elizarraras, Edward, Delgado, Luz, Bernales, Sebastian, Walter, Peter, Rosi, Susanna

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Induction and role of elevated extracellular glutamate during chronic Toxoplasma infection in the brain by Wilson, Emma H., David, Clement N, Landrith, Tyler A, Frias, Elma S, Fiacco, Todd A, Binder, Devin K

“…Abstract Toxoplasma is a prolific parasite found in a third of the world’s population that resides primarily as cysts within the brain of the infected host…”
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Antitumor Activity of a Polypyridyl Chelating Ligand: and Inhibition of Glioma by Clément N. David, Elma S. Frias, Catherine C. Elix, Kathryn E. McGovern, Ameae M. Walker, Jack F. Eichler, Emma H. Wilson

“…Glioblastoma multiforme is an extremely aggressive and invasive form of central nervous system tumor commonly treated with the chemotherapeutic drug…”
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