Search Results - "Freyn, Alec W"

Broadly neutralizing antibodies target a haemagglutinin anchor epitope by Guthmiller, Jenna J., Han, Julianna, Utset, Henry A., Li, Lei, Lan, Linda Yu-Ling, Henry, Carole, Stamper, Christopher T., McMahon, Meagan, O’Dell, George, Fernández-Quintero, Monica L., Freyn, Alec W., Amanat, Fatima, Stovicek, Olivia, Gentles, Lauren, Richey, Sara T., de la Peña, Alba Torrents, Rosado, Victoria, Dugan, Haley L., Zheng, Nai-Ying, Tepora, Micah E., Bitar, Dalia J., Changrob, Siriruk, Strohmeier, Shirin, Huang, Min, García-Sastre, Adolfo, Liedl, Klaus R., Bloom, Jesse D., Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Coughlan, Lynda, Ward, Andrew B., Wilson, Patrick C.

“…Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against…”
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Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals by Zheng, Allen, Sun, Weina, Xiong, Xiaoli, Freyn, Alec W, Peukes, Julia, Strohmeier, Shirin, Nachbagauer, Raffael, Briggs, John A G, Krammer, Florian, Palese, Peter

“…Humoral immune protection against influenza virus infection is mediated largely by antibodies against hemagglutinin (HA) and neuraminidase (NA), the two major…”
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Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice by Freyn, Alec W., Pine, Matthew, Rosado, Victoria C., Benz, Marcel, Muramatsu, Hiromi, Beattie, Mitchell, Tam, Ying K., Krammer, Florian, Palese, Peter, Nachbagauer, Raffael, McMahon, Meagan, Pardi, Norbert

“…Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because…”
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A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice by Freyn, Alec W., Ramos da Silva, Jamile, Rosado, Victoria C., Bliss, Carly M., Pine, Matthew, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., de Souza Ferreira, Luís Carlos, Weissman, Drew, Krammer, Florian, Coughlan, Lynda, Palese, Peter, Pardi, Norbert, Nachbagauer, Raffael

“…Influenza viruses are respiratory pathogens of public health concern worldwide with up to 650,000 deaths occurring each year. Seasonal influenza virus vaccines…”
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A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial by Nachbagauer, Raffael, Feser, Jodi, Naficy, Abdollah, Bernstein, David I., Guptill, Jeffrey, Walter, Emmanuel B., Berlanda-Scorza, Franceso, Stadlbauer, Daniel, Wilson, Patrick C., Aydillo, Teresa, Behzadi, Mohammad Amin, Bhavsar, Disha, Bliss, Carly, Capuano, Christina, Carreño, Juan Manuel, Chromikova, Veronika, Claeys, Carine, Coughlan, Lynda, Freyn, Alec W., Gast, Christopher, Javier, Andres, Jiang, Kaijun, Mariottini, Chiara, McMahon, Meagan, McNeal, Monica, Solórzano, Alicia, Strohmeier, Shirin, Sun, Weina, Van der Wielen, Marie, Innis, Bruce L., García-Sastre, Adolfo, Palese, Peter, Krammer, Florian

“…Seasonal influenza viruses constantly change through antigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictable…”
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A single-shot adenoviral vaccine provides hemagglutinin stalk-mediated protection against heterosubtypic influenza challenge in mice by Bliss, Carly M., Freyn, Alec W., Caniels, Tom G., Leyva-Grado, Victor H., Nachbagauer, Raffael, Sun, Weina, Tan, Gene S., Gillespie, Virginia L., McMahon, Meagan, Krammer, Florian, Hill, Adrian V.S., Palese, Peter, Coughlan, Lynda

“…Conventional influenza vaccines fail to confer broad protection against diverse influenza A viruses with pandemic potential. Efforts to develop a universal…”
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Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance by Liu, Sean T H, Behzadi, Mohammad Amin, Sun, Weina, Freyn, Alec W, Liu, Wen-Chun, Broecker, Felix, Albrecht, Randy A, Bouvier, Nicole M, Simon, Viviana, Nachbagauer, Raffael, Krammer, Florian, Palese, Peter

“…Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses…”
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CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response by Lu, Yisi, Jiang, Roy, Freyn, Alec W, Wang, Jiawei, Strohmeier, Shirin, Lederer, Katlyn, Locci, Michela, Zhao, Hongyu, Angeletti, Davide, O'Connor, Kevin C, Kleinstein, Steven H, Nachbagauer, Raffael, Craft, Joe

“…CD4+ follicular regulatory T (Tfr) cells control B cell responses through the modulation of follicular helper T (Tfh) cells and germinal center development…”
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An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge by Freyn, Alec W, Atyeo, Caroline, Earl, Patricia L, Americo, Jeffrey L, Chuang, Gwo-Yu, Natarajan, Harini, Frey, Tiffany R, Gall, Jason G, Moliva, Juan I, Hunegnaw, Ruth, Asthagiri Arunkumar, Guha, Ogega, Clinton O, Nasir, Arshan, Santos, Genesis, Levin, Rafael H, Meni, Anusha, Jorquera, Patricia A, Bennett, Hamilton, Johnson, Joshua A, Durney, Michael A, Stewart-Jones, Guillaume, Hooper, Jay W, Colpitts, Tonya M, Alter, Galit, Sullivan, Nancy J, Carfi, Andrea, Moss, Bernard

“…Mpox virus (MPXV) caused a global outbreak in 2022. Although smallpox vaccines were rapidly deployed to curb spread and disease among those at highest risk,…”
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First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes by Guthmiller, Jenna J, Han, Julianna, Li, Lei, Freyn, Alec W, Liu, Sean T H, Stovicek, Olivia, Stamper, Christopher T, Dugan, Haley L, Tepora, Micah E, Utset, Henry A, Bitar, Dalia J, Hamel, Natalie J, Changrob, Siriruk, Zheng, Nai-Ying, Huang, Min, Krammer, Florian, Nachbagauer, Raffael, Palese, Peter, Ward, Andrew B, Wilson, Patrick C

“…Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009…”
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Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein by Bailey, Mark J, Broecker, Felix, Freyn, Alec W, Choi, Angela, Brown, Julia A, Fedorova, Nadia, Simon, Viviana, Lim, Jean K, Evans, Matthew J, García-Sastre, Adolfo, Palese, Peter, Tan, Gene S

“…The mosquito-borne Zika virus (ZIKV) has been causing epidemic outbreaks on a global scale. Virus infection can result in severe disease in humans, including…”
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Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes by Freyn, Alec W., Han, Julianna, Guthmiller, Jenna J., Bailey, Mark J., Neu, Karlynn, Turner, Hannah L., Rosado, Victoria C., Chromikova, Veronika, Huang, Min, Strohmeier, Shirin, Liu, Sean T. H., Simon, Viviana, Krammer, Florian, Ward, Andrew B., Palese, Peter, Wilson, Patrick C., Nachbagauer, Raffael

“…In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015…”
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Abbreviated Development of the Brooding Brittle Star Ophioplocus esmarki by Sweet, Hyla C., Doolin, Megan C., Yanowiak, Chelsea N., Coots, Ashley D., Freyn, Alec W., Armstrong, Jane M., Spiecker, Barbara J.

“…The bilaterally symmetrical, feeding larval stage is an ancestral condition in echinoderms. However, many echinoderms have evolved abbreviated development and…”
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Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial by Houser, Katherine V., Chen, Grace L., Carter, Cristina, Crank, Michelle C., Nguyen, Thuy A., Burgos Florez, Maria Claudia, Berkowitz, Nina M., Mendoza, Floreliz, Hendel, Cynthia Starr, Gordon, Ingelise J., Coates, Emily E., Vazquez, Sandra, Stein, Judy, Case, Christopher L., Lawlor, Heather, Carlton, Kevin, Gaudinski, Martin R., Strom, Larisa, Hofstetter, Amelia R., Liang, C. Jason, Narpala, Sandeep, Hatcher, Christian, Gillespie, Rebecca A., Creanga, Adrian, Kanekiyo, Masaru, Raab, Julie E., Andrews, Sarah F., Zhang, Yi, Yang, Eun Sung, Wang, Lingshu, Leung, Kwanyee, Kong, Wing-Pui, Freyn, Alec W., Nachbagauer, Raffael, Palese, Peter, Bailer, Robert T., McDermott, Adrian B., Koup, Richard A., Gall, Jason G., Arnold, Frank, Mascola, John R., Graham, Barney S., Ledgerwood, Julie E.

“…Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable of…”
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COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models by Maisonnasse, Pauline, Aldon, Yoann, Marc, Aurélien, Marlin, Romain, Dereuddre-Bosquet, Nathalie, Kuzmina, Natalia A., Freyn, Alec W., Snitselaar, Jonne L., Gonçalves, Antonio, Caniels, Tom G., Burger, Judith A., Poniman, Meliawati, Bontjer, Ilja, Chesnais, Virginie, Diry, Ségolène, Iershov, Anton, Ronk, Adam J., Jangra, Sonia, Rathnasinghe, Raveen, Brouwer, Philip J. M., Bijl, Tom P. L., van Schooten, Jelle, Brinkkemper, Mitch, Liu, Hejun, Yuan, Meng, Mire, Chad E., van Breemen, Mariëlle J., Contreras, Vanessa, Naninck, Thibaut, Lemaître, Julien, Kahlaoui, Nidhal, Relouzat, Francis, Chapon, Catherine, Ho Tsong Fang, Raphaël, McDanal, Charlene, Osei-Twum, Mary, St-Amant, Natalie, Gagnon, Luc, Montefiori, David C., Wilson, Ian A., Ginoux, Eric, de Bree, Godelieve J., García-Sastre, Adolfo, Schotsaert, Michael, Coughlan, Lynda, Bukreyev, Alexander, van der Werf, Sylvie, Guedj, Jérémie, Sanders, Rogier W., van Gils, Marit J., Le Grand, Roger

“…Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising…”
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An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults by Widge, Alicia T, Hofstetter, Amelia R, Houser, Katherine V, Awan, Seemal F, Chen, Grace L, Burgos Florez, Maria C, Berkowitz, Nina M, Mendoza, Floreliz, Hendel, Cynthia S, Holman, LaSonji A, Gordon, Ingelise J, Apte, Preeti, Liang, C Jason, Gaudinski, Martin R, Coates, Emily E, Strom, Larisa, Wycuff, Diane, Vazquez, Sandra, Stein, Judy A, Gall, Jason G, Adams, William C, Carlton, Kevin, Gillespie, Rebecca A, Creanga, Adrian, Crank, Michelle C, Andrews, Sarah F, Castro, Mike, Serebryannyy, Leonid A, Narpala, Sandeep R, Hatcher, Christian, Lin, Bob C, O'Connell, Sarah, Freyn, Alec W, Rosado, Victoria C, Nachbagauer, Raffael, Palese, Peter, Kanekiyo, Masaru, McDermott, Adrian B, Koup, Richard A, Dropulic, Lesia K, Graham, Barney S, Mascola, John R, Ledgerwood, Julie E

“…Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently…”
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