Search Results - "Frey, Randall S."

Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury by Zhao, You-Yang, Gao, Xiao-Pei, Zhao, Yidan D, Mirza, Muhammad K, Frey, Randall S, Kalinichenko, Vladimir V, Wang, I-Ching, Costa, Robert H, Malik, Asrar B

“…Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis. However, little is known about the…”
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E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury by Bachmaier, Kurt, Toya, Sophie, Gao, Xiaopei, Triantafillou, Thomas, Garrean, Sean, Park, Gye Young, Frey, Randall S, Vogel, Stephen, Minshall, Richard, Christman, John W, Tiruppathi, Chinnaswamy, Malik, Asrar B

“…The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected…”
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Blockade of Class IA Phosphoinositide 3-Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion-dependent Inflammation by Gao, Xiao-Pei, Zhu, Xiangdong, Fu, Jian, Liu, Qinghui, Frey, Randall S., Malik, Asrar B.

“…We examined the role of class IA phosphoinositide 3-kinase (PI3K) in the regulation of activation of NADPH oxidase in PMNs and the mechanism of PMN-dependent…”
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LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils by Zhou, Ximing, Gao, Xiao-Pei, Fan, Jie, Liu, Qinghui, Anwar, Khandaker N, Frey, Randall S, Malik, Asrar B

“…We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response,…”
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TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase by Fan, Jie, Frey, Randall S, Malik, Asrar B

“…Interactions of polymorphonuclear neutrophils (PMNs) with endothelial cells may contribute to the activation of endothelial cell responses involved in innate…”
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SHIP2 Is Recruited to the Cell Membrane upon Macrophage Colony-Stimulating Factor (M-CSF) Stimulation and Regulates M-CSF-Induced Signaling by Wang, Yijie, Keogh, Rosemary J, Hunter, Melissa G, Mitchell, Christina A, Frey, Randall S, Javaid, Kamran, Malik, Asrar B, Schurmans, Stephane, Tridandapani, Susheela, Marsh, Clay B

“…The Src homology 2-containing inositol phosphatase SHIP1 functions in hemopoietic cells to limit activation events mediated by PI3K products, including Akt…”
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NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology by Frey, Randall S, Ushio-Fukai, Masuko, Malik, Asrar B

“…Reactive oxygen species (ROS) including superoxide (O(2)(.-)) and hydrogen peroxide (H(2)O(2)) are produced endogenously in response to cytokines, growth…”
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Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia by Karpurapu, Manjula, Wang, Xuerong, Deng, Jing, Park, Hyesuk, Xiao, Lei, Sadikot, Ruxana T., Frey, Randall S., Maus, Ulrich A., Park, Gye Young, Scott, Edward W., Christman, John W.

“…Although the role of ETS family transcriptional factor PU.1 is well established in macrophage maturation, its role in mature macrophages with reference to…”
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FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression by Mirza, Muhammad K, Sun, Ying, Zhao, Yidan D, Potula, Hari-Hara S K, Frey, Randall S, Vogel, Steven M, Malik, Asrar B, Zhao, You-Yang

“…Repair of the injured vascular intima requires a series of coordinated events that mediate both endothelial regeneration and reannealing of adherens junctions…”
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PKCζ Regulates TNF-α–Induced Activation of NADPH Oxidase in Endothelial Cells by Frey, Randall S, Rahman, Arshad, Kefer, John C, Minshall, Richard D, Malik, Asrar B

“…Although oxidant generation by NADPH oxidase is known to play an important role in signaling in endothelial cells, the basis of activation of NADPH oxidase is…”
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Tumor Necrosis Factor-α Induces Early-Onset Endothelial Adhesivity by Protein Kinase Cζ–Dependent Activation of Intercellular Adhesion Molecule-1 by Javaid, Kamran, Rahman, Arshad, Anwar, Khandaker N, Frey, Randall S, Minshall, Richard D, Malik, Asrar B

“…ABSTRACT—We tested the hypothesis that TNF-α induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface…”
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Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells by Frey, Randall S, Singletary, Keith W

“…Genistein (4',5,7-trihydroxyisoflavone) is an isoflavonoid present in soybeans that exhibits anticarcinogenic effects in breast, colon and prostate cancer…”
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Role of Neutrophil NADPH Oxidase in the Mechanism of Tumor Necrosis Factor-α-induced NF-κB Activation and Intercellular Adhesion Molecule-1 Expression in Endothelial Cells by Fan, Jie, Frey, Randall S., Rahman, Arshad, Malik, Asrar B.

“…In this study, we explored a novel function of polymorphonuclear neutrophils (PMN) NAD(P)H oxidase in the mechanism of tumor necrosis factor-α (TNFα)-induced…”
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Effect of ethanol on proliferation and estrogen receptor-α expression in human breast cancer cells by Singletary, Keith W, Frey, Randall S, Yan, Wen

“…There is substantial epidemiological evidence suggesting that alcohol consumption is associated with increased risk for breast cancer. However, possible…”
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Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury by Gao, Xiao-Pei, Liu, Qinghui, Broman, Michael, Predescu, Dan, Frey, Randall S, Malik, Asrar B

“…Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612 To inactivate chronically the ß 2 -integrin CD11b (Mac-1),…”
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Oxidant signaling in lung cells by Frey, Randall S, Malik, Asrar B

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TGF β regulation of mitogen-activated protein kinases in human breast cancer cells by Frey, Randall S, Mulder, Kathleen M

“…We demonstrate herein the ability of transforming growth factor-beta-2 (TGF β 2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the…”
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Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21waf/cip1, p27kip1, and Cdc25C expression11Abbreviations: PTK, protein tyrosine kinase; cdk, cyclin-dependent kinase; DMEM, Dulbecco’s Modified Eagle’s Medium; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide; and ER, estrogen receptor by Frey, Randall S., Li, Jiyuan, Singletary, Keith W.

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Phosphatidylinositol 3-Kinase γ Signaling through Protein Kinase Cζ Induces NADPH Oxidase-mediated Oxidant Generation and NF-κB Activation in Endothelial Cells by Frey, Randall S., Gao, Xiaopei, Javaid, Kamran, Siddiqui, Shahid S., Rahman, Arshad, Malik, Asrar B.

“…We addressed the role of class 1B phosphatidylinositol 3-kinase (PI3K) isoform PI3Kγ in mediating NADPH oxidase activation and reactive oxidant species (ROS)…”
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TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase by Fan, Jie, Frey, Randall S., Malik, Asrar B.

“…Interactions of polymorphonuclear neutrophils (PMNs) with endothelial cells may contribute to the activation of endothelial cell responses involved in innate…”
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