Search Results - "Frey, Mark R."

The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling by Wang, Linda X, Frey, Mark R, Kohli, Rohit

“…Bile acids are the catabolic end products of cholesterol metabolism that are best known for their role in the digestion of lipids. In the last two decades,…”
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ERBB4 is over-expressed in human colon cancer and enhances cellular transformation by Williams, Christopher S, Bernard, Jessica K, Demory Beckler, Michelle, Almohazey, Dana, Washington, Mary Kay, Smith, Jesse J, Frey, Mark R

“…The ERBB4 receptor tyrosine kinase promotes colonocyte survival. Herein, we tested whether ERBB4's antiapoptotic signaling promotes transformation and…”
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Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms by Golden, Jamie M, Escobar, Oswaldo H, Nguyen, Michelle V L, Mallicote, Michael U, Kavarian, Patil, Frey, Mark R, Gayer, Christopher P

“…The intestinal barrier is often disrupted in disease states, and intestinal barrier failure leads to sepsis. Ursodeoxycholic acid (UDCA) is a bile acid that…”
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Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33 by Schumacher, Michael A., Hsieh, Jonathan J., Liu, Cambrian Y., Appel, Keren L., Waddell, Amanda, Almohazey, Dana, Katada, Kay, Bernard, Jessica K., Bucar, Edie B., Gadeock, Safina, Maselli, Kathryn M., Washington, M. Kay, Grikscheit, Tracy C., Warburton, David, Rosen, Michael J., Frey, Mark R.

“…Dynamic regulation of intestinal cell differentiation is crucial for both homeostasis and the response to injury or inflammation. Sprouty2, an intracellular…”
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Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids by Engevik, Kristen A., Hanyu, Hikaru, Matthis, Andrea L., Zhang, Tongli, Frey, Mark R., Oshima, Yusuke, Aihara, Eitaro, Montrose, Marshall H.

“…Key points Determining the signalling cascade of epithelial repair, using murine gastric organoids, allows definition of regulatory processes intrinsic to…”
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NRG4-ErbB4 signaling represses proinflammatory macrophage activity by Schumacher, Michael A, Dennis, Isabella C, Liu, Cambrian Y, Robinson, Cache, Shang, Judie, Bernard, Jessica K, Washington, M Kay, Polk, D Brent, Frey, Mark R

“…Proinflammatory macrophages are essential drivers of colitis and express the growth factor receptor ErbB4. This study tested the role of ErbB4 and its specific…”
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ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation by Schumacher, Michael A, Hedl, Matija, Abraham, Clara, Bernard, Jessica K, Lozano, Patricia R, Hsieh, Jonathan J, Almohazey, Dana, Bucar, Edie B, Punit, Shivesh, Dempsey, Peter J, Frey, Mark R

“…Efficient clearance of pro-inflammatory macrophages from tissues after resolution of a challenge is critical to prevent prolonged inflammation. Defects in…”
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A Little Disorder Can Be Healthy: PRAP1 as a Protective Factor in the Intestine by Frey, Mark R.

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Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2 by Frey, Mark R.

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A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide by Williams, Jonathan M, Duckworth, Carrie A, Watson, Alastair J M, Frey, Mark R, Miguel, Jennifer C, Burkitt, Michael D, Sutton, Robert, Hughes, Kevin R, Hall, Lindsay J, Caamaño, Jorge H, Campbell, Barry J, Pritchard, D Mark

“…The gut barrier, composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, prevents the entrance of harmful…”
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Intrauterine Growth Restriction Alters Mouse Intestinal Architecture during Development by Fung, Camille M, White, Jessica R, Brown, Ashley S, Gong, Huiyu, Weitkamp, Jörn-Hendrik, Frey, Mark R, McElroy, Steven J

“…Infants with intrauterine growth restriction (IUGR) are at increased risk for neonatal and lifelong morbidities affecting multiple organ systems including the…”
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Neuregulin-4 Is a Survival Factor for Colon Epithelial Cells both in Culture and in Vivo by Bernard, Jessica K., McCann, Sean P., Bhardwaj, Vrinda, Washington, Mary K., Frey, Mark R.

“…Expression of the ErbB4 tyrosine kinase is elevated in colonic epithelial cells during inflammatory bowel disease, whereas ErbB4 overexpression in cultured…”
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Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation by Soroosh, Artin, Fang, Kai, Hoffman, Jill M., Law, Ivy K. M., Videlock, Elizabeth, Lokhandwala, Zulfiqar A., Zhao, Jonathan J., Hamidi, Sepehr, Padua, David M., Frey, Mark R., Pothoulakis, Charalabos, Rankin, Carl R.

“…While apoptosis plays a significant role in intestinal homeostasis, it can also be pathogenic if overactive during recovery from inflammation. We recently…”
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The ErbB4 Growth Factor Receptor Is Required for Colon Epithelial Cell Survival in the Presence of TNF by Frey, Mark R, Edelblum, Karen L, Mullane, Matthew T, Liang, Dongchun, Polk, D. Brent

“…Background & Aims The ErbB4 receptor tyrosine kinase regulates cell growth, survival, and differentiation in several tissues, but its role in the…”
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Colon Cancers Get a Negative (Selection) Attitude by Frey, Mark R., PhD

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Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine by Al Alam, Denise, Danopoulos, Soula, Schall, Kathy, Sala, Frederic G, Almohazey, Dana, Fernandez, G Esteban, Georgia, Senta, Frey, Mark R, Ford, Henri R, Grikscheit, Tracy, Bellusci, Saverio

“…Intestinal epithelial cell renewal relies on the right balance of epithelial cell migration, proliferation, differentiation, and apoptosis. Intestinal…”
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Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration by Dise, Rebecca S, Frey, Mark R, Whitehead, Robert H, Polk, D Brent

“…Regulated intestinal epithelial cell migration plays a key role in wound healing and maintenance of a healthy gastrointestinal tract. Epidermal growth factor…”
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Bacterial Encroachment in Metabolic Syndrome: Too Much Togetherness? by Frey, Mark R., PhD

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Correction: Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation by Soroosh, Artin, Fang, Kai, Hoffman, Jill M., Law, Ivy K. M., Videlock, Elizabeth, Lokhandwala, Zulfiqar A., Zhao, Jonathan J., Hamidi, Sepehr, Padua, David M., Frey, Mark R., Pothoulakis, Charalabos, Rankin, Carl R.

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p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration by Frey, Mark R, Dise, Rebecca S, Edelblum, Karen L, Polk, D Brent

“…Internalization and proteolytic degradation of epidermal growth factor (EGF) receptor (R) following ligand binding is an important mechanism for regulating…”
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