Search Results - "Frey, Armin"

Tetrahydrobiopterin Inhibits Monomerization and Is Consumed during Catalysis in Neuronal NO Synthase by Reif, Andreas, Fröhlich, Lothar G., Kotsonis, Peter, Frey, Armin, Bömmel, Heike M., Schmidt, Harald H.H.W., Wink, David A., Pfleiderer, Wolfgang

“…The biosynthesis of nitric oxide (NO) is catalyzed by homodimeric NO synthases (NOS). For unknown reasons, all NOS co-purify with substoichiometric amounts of…”
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Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity by Kotsonis, P, Frey, A, Fröhlich, L G, Hofmann, H, Reif, A, Wink, D A, Feelisch, M, Schmidt, H H

“…Nitric oxide (NO) synthases (NOSs), which catalyse the oxidation of L-arginine to L-citrulline and an oxide of nitrogen, possibly NO or nitroxyl (NO-), are…”
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Anti-pterins as Tools to Characterize the Function of Tetrahydrobiopterin in NO Synthase by Bömmel, H M, Reif, A, Fröhlich, L G, Frey, A, Hofmann, H, Marecak, D M, Groehn, V, Kotsonis, P, La, M, Köster, S, Meinecke, M, Bernhardt, M, Weeger, M, Ghisla, S, Prestwich, G D, Pfleiderer, W, Schmidt, H H

“…Nitric oxide synthases (NOS) are homodimeric enzymes that NADPH-dependently convert l -arginine to nitric oxide and l -citrulline. Interestingly, all NOS also…”
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Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity by KOTSONIS, Peter, FREY, Armin, FRÖHLICH, Lothar G., HOFMANN, Heinrich, REIF, Andreas, WINK, David A., FEELISCH, Martin, SCHMIDT, Harald H. H. W.

“…Nitric oxide (NO) synthases (NOSs), which catalyse the oxidation of L-arginine to L-citrulline and an oxide of nitrogen, possibly NO or nitroxyl (NO-), are…”
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Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases by Matter, Hans, Kumar, H. S. Arun, Fedorov, Roman, Frey, Armin, Kotsonis, Peter, Hartmann, Elisabeth, Fröhlich, Lothar G, Reif, Andreas, Pfleiderer, Wolfgang, Scheurer, Peter, Ghosh, Dipak K, Schlichting, Ilme, Schmidt, Harald H. H. W

“…Nitric oxide synthesized from l-arginine by nitric oxide synthase isoforms (NOS-I−III) is physiologically important but also can be deleterious when…”
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Structural Requirements for Inhibition of the Neuronal Nitric Oxide Synthase (NOS-I):  3D-QSAR Analysis of 4-Oxo- and 4-Amino-Pteridine-Based Inhibitors by Matter, Hans, Kotsonis, Peter, Klingler, Otmar, Strobel, Hartmut, Fröhlich, Lothar G, Frey, Armin, Pfleiderer, Wolfgang, Schmidt, Harald H. H. W

“…The family of homodimeric nitric oxide synthases (NOS I−III) catalyzes the generation of the cellular messenger nitric oxide (NO) by oxidation of the substrate…”
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Pterin interactions with distinct reductase activities of NO synthase by PANTKE, Morten M., REIF, Andreas, VALTSCHANOFF, Juli G., SHUTENKO, Zhanna, FREY, Armin, WEINBERG, Richard J., PFLEIDERER, Wolfgang, SCHMIDT, Harald H. H. W.

“…Besides oxidizing l-arginine, neuronal NO synthase (NOS) NADPH-dependently reduces various electron acceptors, including cytochrome c and tetrazolium salts…”
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Pterin interactions with distinct reductase activities of NO synthase by Pantke, M M, Reif, A, Valtschanoff, J G, Shutenko, Z, Frey, A, Weinberg, R J, Pfleiderer, W, Schmidt, H H

“…Besides oxidizing L-arginine, neuronal NO synthase (NOS) NADPH-dependently reduces various electron acceptors, including cytochrome c and tetrazolium salts…”
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Biochemical and functional characterization of nitric oxide synthase III gene transfer using a replication-deficient adenoviral vector by Frey, Armin, Schneider-Rasp, Sonja, Marienfeld, Uta, Yu, Julie C.-M, Paul, Martin, Poller, Wolfgang, Schmidt, Harald H.H.W

“…Nitric oxide (NO) produced in endothelial cells has been implicated in the regulation of blood pressure, regional blood flow, inhibition of platelet…”
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Renal toxicity of the neuron-blocking and mitochondriotropic agent m-iodobenzylguanidine by KUIN, A, AALDERS, M, VAN DER VALK, M. A, FREY, A, SCHMIDT, H. H. H. W, SMETS, L. A

“…meta-Iodobenzylguanidine (MIBG) is a multipotent drug used in its radiolabeled form as a tumor-seeking radiopharmaceutical in the diagnosis and treatment of…”
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