Search Results - "Frew, Ian J"

A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma by Frew, Ian J, Moch, Holger

“…The von Hippel-Lindau ( VHL ) tumor suppressor gene is mutated as an early event in almost all cases of clear cell renal cell carcinoma (ccRCC), the most…”
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Therapeutic significance of ARID1A mutation in bladder cancer by Conde, Marina, Frew, Ian J.

“…Bladder cancer (BC) develops from the tissues of the urinary bladder and is responsible for nearly 200,000 deaths annually. This review aims to integrate…”
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HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice by Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, Frew, Ian J.

“…Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α…”
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Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C, Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J, Frew, Ian J

“…Through combined deletion of Vhl , Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates…”
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Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans by Norona, Johana, Apostolova, Petya, Schmidt, Dominik, Ihlemann, Rebekka, Reischmann, Nadine, Taylor, Gregory, Köhler, Natalie, de Heer, Jocelyn, Heeg, Steffen, Andrieux, Geoffroy, Siranosian, Benjamin A., Schmitt-Graeff, Annette, Pfeifer, Dietmar, Catalano, Antonella, Frew, Ian J., Proietti, Michele, Grimbacher, Bodo, Bulashevska, Alla, Bhatt, Ami S., Brummer, Tilman, Clauditz, Till, Zabelina, Tatjana, Kroeger, Nicolaus, Blazar, Bruce R., Boerries, Melanie, Ayuk, Francis, Zeiser, Robert

“…Acute graft-versus-host disease (GVHD) is a life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). Although currently…”
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Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma by Otsuka, Atsushi, Dreier, Jil, Cheng, Phil F, Nägeli, Mirjam, Lehmann, Holger, Felderer, Lea, Frew, Ian J, Matsushita, Shigeto, Levesque, Mitchell P, Dummer, Reinhard

“…Basal cell carcinomas (BCCs) are tumors ignored by immune surveillance. Activated Hedgehog (Hh) signaling within primary cilia is a key driver in the…”
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VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma by Ganner, Athina, Gehrke, Christina, Klein, Marinella, Thegtmeier, Lena, Matulenski, Tanja, Wingendorf, Laura, Wang, Lu, Pilz, Felicitas, Greidl, Lars, Meid, Lisa, Kotsis, Fruzsina, Walz, Gerd, Frew, Ian J., Neumann-Haefelin, Elke

“…Inactivation of the tumor suppressor von Hippel–Lindau ( VHL ) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The…”
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pVHL: a multipurpose adaptor protein by Frew, Ian J, Krek, Wilhelm

“…Mutations in the von Hippel-Lindau tumor suppressor gene VHL occur in various inherited and sporadically occurring tumors. The protein encoded by…”
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Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells by Gonçalves, Ana Filipa, Adlesic, Mojca, Brandt, Simone, Hejhal, Tomas, Harlander, Sabine, Sommer, Lukas, Shakhova, Olga, Wild, Peter J., Frew, Ian J.

“…Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an…”
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Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma by Mohl, Daniel A, Lagies, Simon, Zodel, Kyra, Zumkeller, Matthias, Peighambari, Asin, Ganner, Athina, Plattner, Dietmar A, Neumann-Haefelin, Elke, Adlesic, Mojca, Frew, Ian J, Kammerer, Bernd

“…Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers. The biallelic inactivation of the von Hippel-Lindau tumor suppressor gene ( ) is…”
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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice by Albers, Joachim, Rajski, Michal, Schönenberger, Désirée, Harlander, Sabine, Schraml, Peter, von Teichman, Adriana, Georgiev, Strahil, Wild, Peter J., Moch, Holger, Krek, Wilhelm, Frew, Ian J.

“…The combinations of genetic alterations that cooperate with von Hippel–Lindau ( VHL ) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly…”
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KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation by Ikenberg, Kristian, Valtcheva, Nadejda, Brandt, Simone, Zhong, Qing, Wong, Christine E, Noske, Aurelia, Rechsteiner, Markus, Rueschoff, Jan H, Caduff, Rosmarie, Dellas, Athanassios, Obermann, Ellen, Fink, Daniel, Fuchs, Thomas, Krek, Wilhelm, Moch, Holger, Frew, Ian J, Wild, Peter J

“…Endometrial cancer is the most frequently occurring malignancy of the female genital tract in Western countries. Although in many cases surgically curable,…”
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SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC by Ganner, Athina, Philipp, Antonia, Lagies, Simon, Wingendorf, Laura, Wang, Lu, Pilz, Felicitas, Welte, Thomas, Grand, Kelli, Lienkamp, Soeren S, Klein, Marinella, Kammerer, Bernd, Frew, Ian J, Walz, Gerd, Neumann-Haefelin, Elke

“…Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal cancer, and inactivation of the VHL tumor suppressor gene is found in…”
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Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma by Brandt, Laura P, Albers, Joachim, Hejhal, Tomas, Catalano, Antonella, Wild, Peter J, Frew, Ian J

“…The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial,…”
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p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans by Wild, Peter J., Ikenberg, Kristian, Fuchs, Thomas J., Rechsteiner, Markus, Georgiev, Strahil, Fankhauser, Niklaus, Noske, Aurelia, Roessle, Matthias, Caduff, Rosmarie, Dellas, Athanassios, Fink, Daniel, Moch, Holger, Krek, Wilhelm, Frew, Ian J.

“…Type II endometrial carcinomas are a highly aggressive group of tumour subtypes that are frequently associated with inactivation of the TP53 tumour suppressor…”
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ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma by Seidel, Philipp, Rubarth, Anne, Zodel, Kyra, Peighambari, Asin, Neumann, Felix, Federkiel, Yannick, Huang, Hsin, Hoefflin, Rouven, Adlesic, Mojca, Witt, Christian, Hoffmann, David J, Metzger, Patrick, Lindemann, Ralph K, Zenke, Frank T, Schell, Christoph, Boerries, Melanie, von Elverfeldt, Dominik, Reichardt, Wilfried, Follo, Marie, Albers, Joachim, Frew, Ian J

“…Metastatic clear cell renal cell carcinomas (ccRCCs) are resistant to DNA-damaging chemotherapies, limiting therapeutic options for patients whose tumors are…”
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Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation by Adlesic, Mojca, Frei, Christian, Frew, Ian J

“…The proliferation of intestinal stem cells (ISCs) and differentiation of enteroblasts to form mature enteroendocrine cells and enterocytes in the Drosophila…”
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Combined Vhlh and Pten Mutation Causes Genital Tract Cystadenoma and Squamous Metaplasia by Frew, Ian J., Minola, Andrea, Georgiev, Strahil, Hitz, Manuela, Moch, Holger, Richard, Stéphane, Vortmeyer, Alexander O., Krek, Wilhelm

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Binding Motif for Siah Ubiquitin Ligase by House, Colin M., Frew, Ian J., Huang, Huei-Luen, Wiche, Gerhard, Traficante, Nadia, Nice, Edouard, Catimel, Bruno, David D. L. Bowtell

“…The Drosophila SINA (seven in absentia) protein and its mammalian orthologs (Siah, seven in absentia homolog) are RING domain proteins that function in E3…”
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IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer by Corrò, Claudia, Healy, Marc E, Engler, Stefanie, Bodenmiller, Bernd, Li, Zhe, Schraml, Peter, Weber, Achim, Frew, Ian J, Rechsteiner, Markus, Moch, Holger

“…Recent studies suggest that clear cell renal cell carcinoma (ccRCC) possesses a rare population of cancer stem cells (CSCs) that might contribute to tumor…”
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