Search Results - "Freund, Yvonne R"

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue by Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.

“…Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium…”
Get full text

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis by Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.

“…Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children and causes chronic diarrhea in AIDS patients, but the only approved…”
Get full text

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate by Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin

“…Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical…”
Get full text

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria by HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis by Palencia, Andrés, Bougdour, Alexandre, Brenier‐Pinchart, Marie‐Pierre, Touquet, Bastien, Bertini, Rose‐Laurence, Sensi, Cristina, Gay, Gabrielle, Vollaire, Julien, Josserand, Véronique, Easom, Eric, Freund, Yvonne R, Pelloux, Hervé, Rosenthal, Philip J, Cusack, Stephen, Hakimi, Mohamed‐Ali

“…Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally…”
Get full text

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation by Sindhe, Kirthana M V, Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E, Cooper, Roland A, Plattner, Jacob J, Freund, Yvonne R, DeRisi, Joseph L, Rosenthal, Philip J

“…New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured , against fresh Ugandan isolates, and in murine malaria…”
Get full text

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles by Zhang, Ning, Zoltner, Martin, Leung, Ka-Fai, Scullion, Paul, Hutchinson, Sebastian, Del Pino, Ricardo C, Vincent, Isabel M, Zhang, Yong-Kang, Freund, Yvonne R, Alley, Michael R K, Jacobs, Robert T, Read, Kevin D, Barrett, Michael P, Horn, David, Field, Mark C

“…Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases,…”
Get full text

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis by Ehrens, Alexandra, Lunde, Christopher S, Jacobs, Robert T, Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J, Lenz, Franziska, Fendler, Martina, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J, Freund, Yvonne R, Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J, Hoerauf, Achim, Hübner, Marc P

“…The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In…”
Get full text

Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents by Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Jarnagin, Kurt, Plattner, Jacob J.

“…In vitro SAR of benzoxaborole derivatives against the release of three cytokines, mouse pharmacokinetics, and in vivo activities in mice are reported…”
Get full text

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase by Palencia, Andrés, Liu, Ru-Juan, Lukarska, Maria, Gut, Jiri, Bougdour, Alexandre, Touquet, Bastien, Wang, En-Duo, Li, Xianfeng, Alley, M R K, Freund, Yvonne R, Rosenthal, Philip J, Hakimi, Mohamed-Ali, Cusack, Stephen

“…The apicomplexan parasites Cryptosporidium and Toxoplasma are serious threats to human health. Cryptosporidiosis is a severe diarrheal disease in malnourished…”
Get full text

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase by Sonoiki, Ebere, Palencia, Andres, Guo, Denghui, Ahyong, Vida, Dong, Chen, Li, Xianfeng, Hernandez, Vincent S, Zhang, Yong-Kang, Choi, Wai, Gut, Jiri, Legac, Jennifer, Cooper, Roland, Alley, M R K, Freund, Yvonne R, DeRisi, Joseph, Cusack, Stephen, Rosenthal, Philip J

“…There is a need for new antimalarials, ideally with novel mechanisms of action. Benzoxaboroles have been shown to be active against bacteria, fungi, and…”
Get full text

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT) by Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao

“…[Display omitted] Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation…”
Get full text

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center by Freund, Yvonne R., Akama, Tsutomu, Alley, M.R.K., Antunes, Joana, Dong, Chen, Jarnagin, Kurt, Kimura, Richard, Nieman, James A., Maples, Kirk R., Plattner, Jacob J., Rock, Fernando, Sharma, Rashmi, Singh, Rajeshwar, Sanders, Virginia, Zhou, Yasheen

“…► Novel boron-containing small molecule inhibitors of phosphodiesterase 4. ► Co-crystal structure shows unique binding compared to catechol inhibitors. ► Boron…”
Get full text

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis by Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A

“…A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found…”
Get full text

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6‑(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles by Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Sanders, Virginia, Freund, Yvonne R, Campo, Brice, Rosenthal, Philip J, Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M, Ge, Min, Li, Liang, Ding, Jie, Yang, Yin

“…A series of 6-hetaryloxy benzoxaborole compounds was designed and synthesized for a structure–activity relationship (SAR) investigation to assess the changes…”
Get full text

Synthesis and structure–activity relationships of novel benzoxaboroles as a new class of antimalarial agents by Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Gut, Jiri, Rosenthal, Philip J., Waterson, David, Gamo, Francisco-Javier, Angulo-Barturen, Inigo, Ge, Min, Li, Zhiya, Li, Lingchao, Jian, Yong, Cui, Han, Wang, Hailong, Yang, Jian

“…A series of boron-containing benzoxaborole compounds was designed and synthesized for a SAR investigation for discovering a new antimalarial treatment…”
Get full text

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles by Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Ye, Long, Zhou, Huchen, Waterson, David, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Zhiya, Li, Lingchao, Wang, Hailong, Cui, Han

“…A series of new boron-containing benzoxaborole compounds was designed and synthesized for a continuing structure–activity relationship (SAR) investigation…”
Get full text

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent by Akama, Tsutomu, Virtucio, Charlotte, Dong, Chen, Kimura, Richard, Zhang, Yong-Kang, Nieman, James A., Sharma, Rashmi, Lu, Xiaosong, Sales, Marcelo, Singh, Rajeshwar, Wu, Anne, Fan, Xiao-Qing, Liu, Liang, Plattner, Jacob J., Jarnagin, Kurt, Freund, Yvonne R.

“…Cytokine release inhibitory activity and pharmacokinetics of novel benzoxaborole derivatives are reported. A series of novel…”
Get full text

Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaborole by Dong, Chen, Sexton, Holly, Gertrudes, Ana, Akama, Tsutomu, Martin, Shamra, Virtucio, Charlotte, Chen, Chiao-Wen, Fan, Xiaoqin, Wu, Anne, Bu, Wei, Liu, Liang, Feng, Lisa, Jarnagin, Kurt, Freund, Yvonne R

“…Pro-inflammatory cytokines play a critical role in the development of autoimmune and inflammatory diseases. Targeting the cytokine environment has proven…”
Get more information

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs by Akama, Tsutomu, Freund, Yvonne R, Berry, Pamela W, Carter, David S, Easom, Eric E, Jarnagin, Kurt, Lunde, Christopher S, Plattner, Jacob J, Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bulman, Christina A, Lim, Kee Chong, Suzuki, Brian M, Tricoche, Nancy, Mansour, Abdelmoneim, DiCosty, Utami, McCall, Scott, Carson, Ben, McCall, John W, McKerrow, James, Hübner, Marc P, Specht, Sabine, Hoerauf, Achim, Lustigman, Sara, Sakanari, Judy A, Jacobs, Robert T

“…A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca…”
Get full text