Search Results - "Freund, Ronald K."

β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca2+-permeable AMPA receptors by Sanderson, Jennifer L., Freund, Ronald K., Gorski, Jessica A., Dell’Acqua, Mark L.

“…Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression…”
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Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection by Coultrap, Steven J., Freund, Ronald K., O’Leary, Heather, Sanderson, Jennifer L., Roche, Katherine W., Dell’Acqua, Mark L., Bayer, K. Ulrich

“…Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other…”
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AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors by Sanderson, Jennifer L, Gorski, Jessica A, Gibson, Emily S, Lam, Philip, Freund, Ronald K, Chick, Wallace S, Dell'Acqua, Mark L

“…AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1-GluA4 subunits that mediate the majority of fast excitatory synaptic transmission in…”
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Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase by Hicklin, Tianna R, Wu, Peter H, Radcliffe, Richard A, Freund, Ronald K, Goebel-Goody, Susan M, Correa, Paulo R, Proctor, William R, Lombroso, Paul J, Browning, Michael D

“…Alcohol's deleterious effects on memory are well known. Acute alcohol-induced memory loss is thought to occur via inhibition of NMDA receptor (NMDAR)-dependent…”
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Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction by Lucero, Esteban M., Freund, Ronald K., Smith, Alexandra, Johnson, Noah R., Dooling, Breanna, Sullivan, Emily, Prikhodko, Olga, Ahmed, Md. Mahiuddin, Bennett, David A., Hohman, Timothy J., Dell’Acqua, Mark L., Chial, Heidi J., Potter, Huntington

“…Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule…”
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Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling by Prikhodko, Olga, Freund, Ronald K, Sullivan, Emily, Kennedy, Matthew J, Dell'Acqua, Mark L

“…Neuronal excitatory synapses are primarily located on small dendritic protrusions called spines. During synaptic plasticity underlying learning and memory, Ca…”
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LTP induction by structural rather than enzymatic functions of CaMKII by Tullis, Jonathan E., Larsen, Matthew E., Rumian, Nicole L., Freund, Ronald K., Boxer, Emma E., Brown, Carolyn Nicole, Coultrap, Steven J., Schulman, Howard, Aoto, Jason, Dell’Acqua, Mark L., Bayer, K. Ulrich

“…Learning and memory are thought to require hippocampal long-term potentiation (LTP), and one of the few central dogmas of molecular neuroscience that has stood…”
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The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome by Sanderson, Jennifer L., Freund, Ronald K., Castano, Anna M., Benke, Timothy A., Dell’Acqua, Mark L.

“…Genetic alterations in autism spectrum disorders (ASD) frequently disrupt balance between synaptic excitation and inhibition and alter plasticity in the…”
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LTP expression mediated by autonomous activity of GluN2B-bound CaMKII by Rumian, Nicole L., Barker, C. Madison, Larsen, Matthew E., Tullis, Jonathan E., Freund, Ronald K., Taslimi, Amir, Coultrap, Steven J., Tucker, Chandra L., Dell’Acqua, Mark L., Bayer, K. Ulrich

“…Learning and memory are thought to require the induction and maintenance of long-term potentiation (LTP) of synaptic strength. LTP induction requires the…”
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CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage by Buard, Isabelle, Coultrap, Steven J, Freund, Ronald K, Lee, Yong-Seok, Dell'Acqua, Mark L, Silva, Alcino J, Bayer, K Ulrich

“…Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) "autonomy" (T286-autophosphorylation-induced Ca(2+)-independent activity) is required for…”
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Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss by Freund, Ronald K, Gibson, Emily S, Potter, Huntington, Dell'Acqua, Mark L

“…Alzheimer's disease (AD) is characterized by neurofibrillary tangles, amyloid plaques, and neurodegeneration. However, this pathology is preceded by increased…”
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Commentary: How Ethanol Short-Circuits the Cerebellum-Actions on Golgi Cells in Freely-Moving Animals by Freund, Ronald K.

“…This commentary discusses the important contributions of the article published in this journal by Huang and colleagues, titled, “Acute ethanol exposure…”
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Genetic knockout of the α7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner by Freund, Ronald K., Graw, Sharon, Choo, Kevin S., Stevens, Karen E., Leonard, Sherry, Dell’Acqua, Mark L.

“…•Both α7nAChR function and genetic background are important in schizophrenia.•C57/Bl6 and C3H mice differ in background expression of α7nAChRs…”
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Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits by Corser-Jensen, Chelsea E., Goodell, Dayton J., Freund, Ronald K., Serbedzija, Predrag, Murphy, Robert C., Farias, Santiago E., Dell'Acqua, Mark L., Frey, Lauren C., Serkova, Natalie, Heidenreich, Kim A.

“…Neuroinflammation is a component of secondary injury following traumatic brain injury (TBI) that can persist beyond the acute phase. Leukotrienes are potent,…”
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Calcineurin activation and scaffolding in Aß‐induced synaptic dysfunction by Prikhodko, Olga, Sanderson, Jennifer L, Freund, Ronald K, Sullivan, Emily, Kennedy, Matthew J, Dell'Acqua, Mark L

“…Background Calcineurin (CaN) is a protein phosphatase that is essential for synaptic long‐term depression (LTD) through its regulation of AMPA‐type glutamate…”
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Commentary: How Ethanol Short‐Circuits the Cerebellum—Actions on G olgi Cells in Freely—Moving Animals by Freund, Ronald K.

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Potentiation of ethanol effects in cerebellum by activation of endogenous noradrenergic inputs by Wang, Y, Freund, R K, Palmer, M R

“…We previously found that beta adrenergic agonists such as norepinephrine and isoproterenol potentiate the depressant actions of ethanol (EtOH) on cerebellar…”
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Differences in norepinephrine clearance in cerebellar slices from low-alcohol-sensitive and high-alcohol-sensitive rats by Freund, Ronald K, Gerhardt, Greg A, Marshall, Kriste E, Palmer, Michael R

“…High-alcohol-sensitive (HAS) and low-alcohol-sensitive (LAS) rats were bred for sensitivity and insensitivity, respectively, to the sedative/hypnotic effects…”
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The Ca V 1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca 2+ channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome by Sanderson, Jennifer L, Freund, Ronald K, Castano, Anna M, Benke, Timothy A, Dell'Acqua, Mark L

“…Genetic alterations in autism spectrum disorders (ASD) frequently disrupt balance between synaptic excitation and inhibition and alter plasticity in the…”
Get full text

β-Amyloid disruption of LTP/LTD balance is mediated by AKAP150-anchored PKA and Calcineurin regulation of Ca 2+ -permeable AMPA receptors by Sanderson, Jennifer L, Freund, Ronald K, Gorski, Jessica A, Dell'Acqua, Mark L

“…Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression…”
Get full text