Search Results - "Freund, Malika"

Probabilistic fine-mapping of transcriptome-wide association studies by Mancuso, Nicholas, Freund, Malika K., Johnson, Ruth, Shi, Huwenbo, Kichaev, Gleb, Gusev, Alexander, Pasaniuc, Bogdan

“…Transcriptome-wide association studies using predicted expression have identified thousands of genes whose locally regulated expression is associated with…”
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Leveraging Polygenic Functional Enrichment to Improve GWAS Power by Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.

“…Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a…”
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Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data by Shi, Huwenbo, Burch, Kathryn S., Johnson, Ruth, Freund, Malika K., Kichaev, Gleb, Mancuso, Nicholas, Manuel, Astrid M., Dong, Natalie, Pasaniuc, Bogdan

“…Despite strong transethnic genetic correlations reported in the literature for many complex traits, the non-transferability of polygenic risk scores across…”
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Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI by Major, Megan, Freund, Malika K., Burch, Kathryn S., Mancuso, Nicholas, Ng, Michael, Furniss, Dominic, Pasaniuc, Bogdan, Ophoff, Roel A.

“…Dupuytren's disease is a common inherited tissue‐specific fibrotic disorder, characterized by progressive and irreversible fibroblastic proliferation affecting…”
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Electronic health record signatures identify undiagnosed patients with common variable immunodeficiency disease by Johnson, Ruth, Stephens, Alexis V, Mester, Rachel, Knyazev, Sergey, Kohn, Lisa A, Freund, Malika K, Bondhus, Leroy, Hill, Brian L, Schwarz, Tommer, Zaitlen, Noah, Arboleda, Valerie A, A Bastarache, Lisa, Pasaniuc, Bogdan, Butte, Manish J

“…Human inborn errors of immunity include rare disorders entailing functional and quantitative antibody deficiencies due to impaired B cells called the common…”
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Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative by Johnson, Ruth, Ding, Yi, Venkateswaran, Vidhya, Bhattacharya, Arjun, Boulier, Kristin, Chiu, Alec, Knyazev, Sergey, Schwarz, Tommer, Freund, Malika, Zhan, Lingyu, Burch, Kathryn S, Caggiano, Christa, Hill, Brian, Rakocz, Nadav, Balliu, Brunilda, Denny, Christopher T, Sul, Jae Hoon, Zaitlen, Noah, Arboleda, Valerie A, Halperin, Eran, Sankararaman, Sriram, Butte, Manish J, Lajonchere, Clara, Geschwind, Daniel H, Pasaniuc, Bogdan

“…Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic…”
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Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits by Freund, Malika Kumar, Burch, Kathryn S., Shi, Huwenbo, Mancuso, Nicholas, Kichaev, Gleb, Garske, Kristina M., Pan, David Z., Miao, Zong, Mohlke, Karen L., Laakso, Markku, Pajukanta, Päivi, Pasaniuc, Bogdan, Arboleda, Valerie A.

“…Although recent studies provide evidence for a common genetic basis between complex traits and Mendelian disorders, a thorough quantification of their overlap…”
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BATMAN: Fast and Accurate Integration of Single-Cell RNA-Seq Datasets via Minimum-Weight Matching by Mandric, Igor, Hill, Brian L., Freund, Malika K., Thompson, Michael, Halperin, Eran

“…Single-cell RNA-sequencing (scRNA-seq) is a set of technologies used to profile gene expression at the level of individual cells. Although the throughput of…”
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Author Correction: Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative by Johnson, Ruth, Ding, Yi, Venkateswaran, Vidhya, Bhattacharya, Arjun, Boulier, Kristin, Chiu, Alec, Knyazev, Sergey, Schwarz, Tommer, Freund, Malika, Zhan, Lingyu, Burch, Kathryn S, Caggiano, Christa, Hill, Brian, Rakocz, Nadav, Balliu, Brunilda, Denny, Christopher T, Sul, Jae Hoon, Zaitlen, Noah, Arboleda, Valerie A, Halperin, Eran, Sankararaman, Sriram, Butte, Manish J, Lajonchere, Clara, Geschwind, Daniel H, Pasaniuc, Bogdan

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H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility by Giambartolomei, Claudia, Seo, Ji-Heui, Schwarz, Tommer, Freund, Malika Kumar, Johnson, Ruth Dolly, Spisak, Sandor, Baca, Sylvan C., Gusev, Alexander, Mancuso, Nicholas, Pasaniuc, Bogdan, Freedman, Matthew L.

“…Genome-wide association studies (GWASs) have identified more than 200 prostate cancer (PrCa) risk regions, which provide potential insights into causal…”
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Exploring the Roles of Genetic Regulation in Human Phenotypes by Freund, Malika Kumar

“…Human phenotypes are influenced to varying extents by inherited genetic variation, although specific mechanisms through which this variation affects the…”
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Increasing equity in science requires better ethics training: A course by trainees, for trainees by Patel, Roshni A., Ungar, Rachel A., Pyke, Alanna L., Adimoelja, Alvina, Chakraborty, Meenakshi, Cotter, Daniel J., Freund, Malika, Goddard, Pagé, Gomez-Stafford, Justin, Greenwald, Emily, Higgs, Emily, Hunter, Naiomi, MacKenzie, Tim M.G., Narain, Anjali, Gjorgjieva, Tamara, Martschenko, Daphne O.

“…Despite the profound impacts of scientific research, few scientists have received the necessary training to productively discuss the ethical and societal…”
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Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors by Chang, Timothy S., Ding, Yi, Freund, Malika K., Johnson, Ruth, Schwarz, Tommer, Yabu, Julie M., Hazlett, Chad, Chiang, Jeffrey N., Wulf, David A., Antonio, Anna L., Ariannejad, Maryam, Badillo, Angela M., Balliu, Brunilda, Berkovich, Yael, Broudy, Michael, Dang, Tony, Denny, Chris, Eskin, Eleazar, Halperin, Eran, Hill, Brian L., Jain, Ankur, Katakwar, Vivek, Lajonchere, Clara, Magyar, Clara, Minton, Sheila, Mohammed, Ghouse, Muhamed, Ariff, Pavan, Pabba, Pfeffer, Michael A., Rakocz, Nadav, Rudas, Akos, Salonga, Rey, Sanders, Timothy J., Tung, Paul, Vu, Vu, Zheng, Ailsa, Geschwind, Daniel H., Butte, Manish J., Pasaniuc, Bogdan

“…Coronavirus disease 2019 (COVID-19) has exposed health care disparities in minority groups including Hispanics/Latinxs (HL). Studies of COVID-19 risk factors…”
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