Search Results - "Freund, John M."

Quantification of DNA in Biologic Scaffold Materials by Gilbert, Thomas W., Ph.D, Freund, John M., B.S, Badylak, Stephen F., D.V.M., Ph.D., M.D

“…Biological scaffold materials composed of extracellular matrix (ECM) are routinely used for a variety of clinical applications ranging from the treatment of…”
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The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds by Reing, Janet E, Brown, Bryan N, Daly, Kerry A, Freund, John M, Gilbert, Thomas W, Hsiong, Susan X, Huber, Alexander, Kullas, Karen E, Tottey, Stephen, Wolf, Matthew T, Badylak, Stephen F

“…Abstract Biologic materials from various species and tissues are commonly used as surgical meshes or scaffolds for tissue reconstruction. Extracellular matrix…”
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Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications by Stewart, Amy Stieler, Schaaf, Cecilia R, Veerasammy, Brittany, Freund, John M, Gonzalez, Liara M

“…Equine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to isolate and store ISCs…”
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Comparison of three methods for the derivation of a biologic scaffold composed of adipose tissue extracellular matrix by Brown, Bryan N, Freund, John M, Han, Li, Rubin, J Peter, Reing, Janet E, Jeffries, Eric M, Wolf, Mathew T, Tottey, Stephen, Barnes, Christopher A, Ratner, Buddy D, Badylak, Stephen F

“…Extracellular matrix (ECM)-based scaffold materials have been used successfully in both preclinical and clinical tissue engineering and regenerative medicine…”
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Assessment of equine intestinal epithelial junctional complexes and barrier permeability using a monolayer culture system by Stewart, Amy Stieler, Kopper, Jamie J., McKinney-Aguirre, Caroline, Veerasamy, Brittany, Sahoo, Dipak Kumar, Freund, John M., Gonzalez, Liara M.

“…Gastrointestinal disease is a leading cause of death in mature horses. A lack of in vitro modeling has impeded the development of novel therapeutics. The…”
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An elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair by Hong, Yi, Takanari, Keisuke, Amoroso, Nicholas J, Hashizume, Ryotaro, Brennan-Pierce, Ellen P, Freund, John M, Badylak, Stephen F, Wagner, William R

“…A biodegradable elastomeric scaffold was created by electrospinning a mixed solution of poly(ester urethane)urea (PEUU) and porcine dermal extracellular matrix…”
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HOPX + injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia by Stewart, Amy Stieler, Schaaf, Cecilia Renee, Luff, Jennifer A, Freund, John M, Becker, Thomas C, Tufts, Sara R, Robertson, James B, Gonzalez, Liara M

“…Intestinal ischemia is a life-threatening emergency with mortality rates of 50%-80% due to epithelial cell death and resultant barrier loss. Loss of the…”
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A Single Amino Acid Residue at Transmembrane Domain 4 of the α Subunit Influences Carisoprodol Direct Gating Efficacy at GABA A Receptors by Kumar, Manoj, Kumar, Manish, Freund, John M, Dillon, Glenn H

“…The muscle relaxant carisoprodol has recently been controlled at the federal level as a Schedule IV drug due to its high abuse potential and consequences of…”
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Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation by Agrawal, Vineet, Tottey, Stephen, Johnson, Scott A, Freund, John M, Siu, Bernard F, Badylak, Stephen F

“…Biologic scaffolds composed of extracellular matrix (ECM) have been used successfully in preclinical models and humans for constructive remodeling of…”
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Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response by Wolf, Matthew T., Carruthers, Christopher A., Dearth, Christopher L., Crapo, Peter M., Huber, Alexander, Burnsed, Olivia A., Londono, Ricardo, Johnson, Scott A., Daly, Kerry A., Stahl, Elizabeth C., Freund, John M., Medberry, Christopher J., Carey, Lisa E., Nieponice, Alejandro, Amoroso, Nicholas J., Badylak, Stephen F.

“…Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These materials provide robust mechanical strength and are…”
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Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia by Stieler Stewart, Amy, Freund, John M, Blikslager, Anthony T, Gonzalez, Liara M

“…Intestinal ischemia remains a major cause of morbidity and mortality in human and veterinary patients. Many disease processes result in intestinal ischemia,…”
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Enteroendocrine Progenitor Cell–Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner by Singh, Ajeet P., Hung, Yu-Han, Shanahan, Michael T., Kanke, Matt, Bonfini, Alessandro, Dame, Michael K., Biraud, Mandy, Peck, Bailey C.E., Oyesola, Oyebola O., Freund, John M., Cubitt, Rebecca L., Curry, Ennessa G., Gonzalez, Liara M., Bewick, Gavin A., Tait-Wojno, Elia D., Kurpios, Natasza A., Ding, Shengli, Spence, Jason R., Dekaney, Christopher M., Buchon, Nicolas, Sethupathy, Praveen

“…The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to intestinal epithelial…”
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Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response by Wolf, Matthew T., Carruthers, Christopher A., Dearth, Christopher L., Crapo, Peter M., Huber, Alexander, Burnsed, Olivia A., Londono, Ricardo, Johnson, Scott A., Daly, Kerry A., Stahl, Elizabeth C., Freund, John M., Medberry, Christopher J., Carey, Lisa E., Nieponice, Alejandro, Amoroso, Nicholas J., Badylak, Stephen F.

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Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion by BREDEL, M, POLLACK, I. F, FREUND, J. M, RUSNAK, J, LAZO, J. S

“…Recent studies in our laboratory have shown that UCN-01 (7-hydroxystaurosporine), which is a derivative of the non-selective protein kinase inhibitor…”
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Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia by Stieler Stewart, Amy, Freund, John M, Blikslager, Anthony T, Gonzalez, Liara M

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Enteroendocrine Progenitor Cell–Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent MannerSummary by Ajeet P. Singh, Yu-Han Hung, Michael T. Shanahan, Matt Kanke, Alessandro Bonfini, Michael K. Dame, Mandy Biraud, Bailey C.E. Peck, Oyebola O. Oyesola, John M. Freund, Rebecca L. Cubitt, Ennessa G. Curry, Liara M. Gonzalez, Gavin A. Bewick, Elia D. Tait-Wojno, Natasza A. Kurpios, Shengli Ding, Jason R. Spence, Christopher M. Dekaney, Nicolas Buchon, Praveen Sethupathy

“…Background & Aims: The enteroendocrine cell (EEC) lineage is important for intestinal homeostasis. It was recently shown that EEC progenitors contribute to…”
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ASSOCIATION FOR ACADEMIC SURGERY, 2008 Quantification of DNA in Biologic Scaffold Materials by GILBERT, Thomas W, FREUND, John M, BADYLAK, Stephen F

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Polypropylene surgical mesh coated with extracellular matrix mitigates the host foreign body response: Polypropylene Surgical Mesh Coated With ECM by Wolf, Matthew T., Carruthers, Christopher A., Dearth, Christopher L., Crapo, Peter M., Huber, Alexander, Burnsed, Olivia A., Londono, Ricardo, Johnson, Scott A., Daly, Kerry A., Stahl, Elizabeth C., Freund, John M., Medberry, Christopher J., Carey, Lisa E., Nieponice, Alejandro, Amoroso, Nicholas J., Badylak, Stephen F.

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Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth by Bredel, M, Pollack, I F, Freund, J M, Hamilton, A D, Sebti, S M

“…Preliminary studies have demonstrated that the Ras family and related guanosine 5'-triphosphate-dependent proteins (G-proteins) are overactivated in malignant…”
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Induction of apoptosis and growth regulation of malignant gliomas: UCN-01, a selective inhibitor of protein kinase C, blocks glioma proliferation in vitro by Bredel, Markus, Pollack, Ian F., Freund, John M., Rusnak, James, Lazo, John S.

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